Wednesday, December 31, 2008

Effect Measure On The Recent Genetic Study Of The Virulence Of The Spanish Flu

 

# 2611

 

 

 

 

Whenever a highly technical scientific paper comes out (anything that is more challenging than, say, McGuffey's Reader),  I wait in hopes that one of the Reveres at Effect Measure will write a blog that explains it to me.

 

It's no secret that anything beyond basic virology and genetics is way above my pay grade.

 

Over the weekend, we saw headlines about a new study that `unlocks the secrets of the 1918 pandemic virus'.   This is, of course, the latest in a series of recent papers purporting to unlock the mysteries of the Spanish Flu. 

 

Today Effect Measure dissects this new study for us.  

 

Highly recommended.

 

 

Another flu paper that "unlocks the secret" of 1918 virus virulence

Category: Bird flu • biology
Posted on: December 31, 2008 7:47 AM, by revere

Study: Tamiflu Resistant Flu Linked To Higher Pneumonia Rates

 

# 2610

 

 

It is a truism in science that the longer we look, the more we learn.

 

 

Four years ago, when the first oseltamivir-resistant influenza studies were conducted on ferrets, scientists were heartened to discover that most resistant strains showed compromised biological fitness in the laboratory. 

 

In other words, they did not seem to be easily transmitted. And that gave hope that the mutation that conferred Tamiflu-resistance also made it a dead-end virus.

 

Today, of course, we know that those early hopes were based on insufficient data.   Tamiflu resistant H1N1 viruses have spread globally over the past year, and now have been found in nearly every country that is testing for it.

 

Among the H1N1 viruses (H3N2 are still sensitive to Tamiflu), in some countries, the percentage of resistant samples is approaching 100%.

 

These resistant viruses are obviously just as fit, and transmissible, as the non-resistant variety.

 

Preliminary data, according to the CDC, had suggested that these resistant strains produced no more severe symptoms than its Tamiflu-sensitive cousin, but now, that assumption is being called into question by a study conducted by Norwegian doctors to be published in the CDC's Journal of Emerging Infectious Diseases.

 

While this data is preliminary, and based on a very small sampling, it suggests that the Tamiflu resistant H1N1 strain may cause a higher incidence of pneumonia and sinusitis than the regular H1N1 strain.

 

While the study group was too small to draw immediate conclusions, the authors believe their findings warrant further investigation.

 

 

Jason Gale, of Bloomberg News, has the story.    Follow the link to read it in its entirety.

 

 

 

Drug-Resistant Flu Linked With Pneumonia, Norwegian Doctors Say

 

By Jason Gale

Dec. 31 (Bloomberg) -- A drug-resistant influenza strain that has spread globally this year needs further study to gauge its virulence, according to doctors in Norway who found the bug was linked with patients suffering more severe symptoms.

 

A form of the H1N1 seasonal flu virus that evades Roche Holding AG's Tamiflu appeared more likely to cause pneumonia and sinusitis than the H1N1 strain without the resistance-causing mutation, researchers from the Norwegian Institute of Public Health in Oslo and the U.K.'s Health Protection Agency said.

 

While ``not a statistically significant finding,'' results of the study, involving fewer than 300 patients, ``warrant further investigation,'' the authors said. The study was released online today ahead of publication in the February edition of Emerging Infectious Diseases by the U.S. Centers for Disease Control and Prevention.

 

Tamiflu-evading influenza has been reported in 50 countries on six continents since widespread resistance to the bestselling antiviral was first reported to the World Health Organization by Norway in January. Its emergence prompted doctors to consider other medicines, such as GlaxoSmithKline Plc's Relenza, to fight a disease the WHO estimates causes 250,000 to 500,000 deaths annually.

(Continue . . .)

China: Infant With H9 Is An Isolated Case

 

# 2609

 

 

 

While exactly where the H9N2 virus that infected an 82-day-old baby in Southern China came from remains a mystery, Xinhua - the official news agency of the Chinese government - is reporting that the virus does not appear to have been passed on to any of the baby's contacts.

 

The baby's grandmother, and 8 hospital staff have all been tested, and found not to be infected.

 

 

 

Shenzhen says no further bird flu infections after infant case

www.chinaview.cn 2008-12-31 20:56:10

    SHENZHEN, Dec. 31 (Xinhua) -- No further infections of bird flu have been detected here in southern China, where an 82-day-old baby girl contracted the disease, a city health bureau spokesman said on Wednesday.

 

    The girl, surnamed Chen, was born in Hong Kong. She had been living in Xiabaishi Village, Nanshan District with her grandmother while her parents were working in Hong Kong.

 

    The baby fell ill last Monday and was diagnosed as having the H9N2 bird flu strain on Tuesday in a Hong Kong hospital, the spokesman said.

 

    Experts from the city's health bureau and disease control center went to the village to investigate. They collected blood samples from the baby's grandmother and eight staff members in a local hospital who had contact with the baby. No virus was detected in those samples.

 

    Experts also investigated a restaurant near the patient's home that kept live chickens. No virus was found in blood samples from four staff members of the restaurant.

 

    The disease control center has sterilized the area around the baby's home and the hospital where she sought treatment.

 

    Experts said the H9N2 bird flu strain is less pathogenic than the H5N1 strain.

Tuesday, December 30, 2008

`Killer' Headlines From The UK

 


# 2608

 

 

 

Tabloid style headlines are very popular around the world, and certainly that is true in the United Kingdom.   Headlines sell papers, but they aren't always an accurate barometer of the contents of a news article.

 

They do, however, usually contain at least a hint of the truth.   Some of the headlines I've seen in the past couple of days include.

 

 

'Killer' Australian flu strain set to spread across UK, experts warn   Daily Mail, UK - Dec 29, 2008

 

KILLER FLU HITS BRITAIN UK Express

 

Flu expected to worsen as deadly Australian strain hits Europe Telegraph.co.uk

 

 

So what's the truth?  Is there really a `killer flu' sweeping through Europe?

 

With provisions, the answer is  sorta, yes. 

 

There is no doubt that Europe in general, and the UK in particular, are seeing a bad flu season.   It has reached near-epidemic levels at least a month earlier than usual, and these levels are likely not to peak until late January or February.

 

As many as 11 other European nations are reporting increasing numbers of influenza cases, and most of those appear to be due to H3N2  - the so-called Brisbane strain of the virus.

 

This strain first showed up in the summer of 2007 in Australia, and was responsible for a half-dozen child deaths.  Since it was a new strain of the existing H3N2 virus, the vaccine in use last Winter did not cover it. 

 

This year's vaccine does.

 

So, is this a `killer strain'?

 

All flu strains are killers of course, but this one does seem to be causing more severe illness than most recent seasonal strains.   So, while the headlines are `hyped', it isn't without some basis.

 

The last really bad flu year in the UK was 1999, when 22,000 people reportedly died due to complication of influenza.   That is 4 or 5 times higher than most years.

 

There are concerns that this year could approach those numbers.

 

I received an email this morning from a dear friend who happens to be a  GP in the UK.  He writes that his consultation rate has tripled in the past few weeks, and that he's seeing a lot of secondary bacterial infections on top of viral influenza-like infections - so-called "purulent bronchitis".

 

 

I've no doubt that this year is going to be a bad flu year, with more than the usual number of deaths associated with it in the UK. 

 

So I guess calling it a `killer flu' isn't that far off.

 

 

Still, I find myself a  little uncomfortable by the use of that sort of hyperbole.  It seems, somehow, excessive.

 

Call it an editorial decision.   A matter of style.

 

I think that certain words and phrases lose their impact when they are used too cavalierly.  I prefer to save `high impact' words for when I really want people to pay attention.  

 

Like profanity, I feel that they are generally most effective when used sparingly.

 

 

 

Just a side note for my American readers.  So far, the H3N2 Brisbane virus doesn't appear to be making much of an impact here in the states, as most of the flu cases identified so far are of the H1N1 variety.  

 

That could change as the season progresses, however.

Revisiting A Malik Peiris Interview On H9N2

 

# 2607

 

 

 

With today's news that a baby has tested positive in a Hong Kong hospital for the H9N2 virus, it is probably a good time to go back to an interview given last August by world famous microbiologist Malik Peiris.

 

Peiris, indisputably one of the heroes of the 2003 SARS outbreak, cautioned that the H9N2 virus may be circulating far more commonly than we believe. 

 

I covered this story in my blog, Fluing Under The Radar, on August 15th of this year.

 

Since the link on the Reuters story in that blog appears no longer active, I'll reprint an except here, with a new link.

 

By all means, follow the link to read the entire article.

 

 

 

 

H9N2 bird flu threat understated in humans

Fri Aug 15, 2008 6:55am EDT

 

Photo

 

HONG KONG (Reuters) - The H9N2 bird flu strain, identified as a possible pandemic threat, could be infecting more humans than commonly thought but its mild symptoms mean it often goes undetected, a leading Hong Kong bird flu expert said.

 

"It's quite possible ... H9N2 is infecting humans quite a lot, much (more) than we appreciate merely because it is beyond the radar," Malik Peiris, a Hong Kong-based microbiologist, told Reuters.

 

"In humans, it is very mild, so most of the time it's probably not even recognized or biologically tested," said Peiris, who has co-authored several papers on the strain in recent years.

 

<SNIP>

 

However, flu experts at the University of Maryland, St. Jude's Children's Research hospital in Memphis and elsewhere recently wrote in the Public Library of Science journal PLoS ONE that the H9N2 strain posed a "significant threat for humans".

 

They found that just a few mutations could turn it into a virus that people catch and transmit easily.

 

Peiris said that while the H9N2 strain might be more transmissible, its effects would be far less devastating than a possible H5N1 pandemic.

 

"There are other viruses out there besides H5N1 that could be the next pandemic," Peiris said. "But I suspect (H9N2) will not be so severe in its outcome."

 

(Continue . . .)

 

CDC Podcast: Using Protective Gear In A Bird Flu Outbreak

 

 

# 2606

 

 

The CDC produces frequent, short, informational podcasts (audio and/or video reports) on a variety of health issues each month.   You can access the latest releases by clicking the logo below

 

image

 

or visiting  http://www2a.cdc.gov/podcasts/index.asp 

 

 

A small sampling of some of the holiday offerings this month included:

 

Healthy Holidays
Listen to the podcast
Listen To This Podcast... (3:34)

This podcast includes simple ways to eat healthy and get active during the winter holidays and throughout the New Year.  (Created: 12/7/2008 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP))
Date Released: 12/7/2008

 

Give the gift of health and safety to yourself and others by following these holiday tips.

Twelve Holiday Health and Safety Tips
Listen to the podcast
Listen To This Podcast... (3:40)


Give the gift of health and safety to yourself and others by following these holiday tips.  (Created: 12/14/2007 by CDC, Office of Women's Health)
Date Released: 12/17/2007

 

This podcast discusses important steps you can take to make sure food safety is a regular ingredient in preparing foods this holiday season.

Holiday Food Safety
Listen to the podcast
Listen To This Podcast... (3:29)


This podcast discusses important steps you can take to make sure food safety is a regular ingredient in preparing foods this holiday season.  (Created: 11/14/2008 by National Center for Zoonotic, Vector-borne, and Enteric Diseases (NCZVED))
Date Released: 11/17/2008

 

This podcast emphasizes the importance of flu vaccination for baby boomers in order to protect the health of themselves and those around them.

Baby Boomers Need Flu Shots, Too!
Listen to the podcast
Listen To This Podcast... (2:09)


This podcast emphasizes the importance of flu vaccination for baby boomers in order to protect the health of themselves and those around them.  (Created: 12/18/2008 by National Center for Immunizations and Respiratory Diseases (NCIRD))
Date Released: 12/18/2008

 

These are good, informative segments, and are geared to the general public. 

 

 

Today's podcast is an interview with Dr. Oliver Morgan, who has recently joined the CDC.   He conducted a study, which appears in January's Journal of Emerging Infectious Diseases, on the efficacy of personal protective equipment when dealing with a bird flu outbreak.

 

The study, Personal Protective Equipment and Risk for Avian Influenza (H7N3), is available in full online.

 

Morgan O, Kuhne M, Nair P, Verlander NQ, Preece R, McDougal M, et al. Personal protective equipment and risk for avian influenza (H7N3). Emerg Infect Dis [serial on the Internet]. 2009 Jan [date cited]. Available from http://www.cdc.gov/EID/content/15/1/59.htm

DOI: 10.3201/eid1501.070660

 

Abstract


An outbreak of avian influenza (H7N3) among poultry resulted in laboratory-confirmed disease in 1 of 103 exposed persons. Incomplete use of personal protective equipment (PPE) was associated with conjunctivitis and influenza-like symptoms. Rigorous use of PPE by persons managing avian influenza outbreaks may reduce exposure to potentially hazardous infected poultry materials.

 

Today's podcast is an overview of this study. It runs just under 5 minutes.

 

 

 

CDC's Dr. Oliver Morgan discusses how the use of masks and other protective gear impacted whether workers dealing with an outbreak of bird flu in England became sick. The paper is published in the January 2009 issue of CDC’s journal, Emerging Infectious Diseases.

Use of Protective Gear in Bird Flu Outbreak Response
Listen to the podcast
Listen To This Podcast... (4:56)

 


CDC's Dr. Oliver Morgan discusses how the use of masks and other protective gear impacted whether workers dealing with an outbreak of bird flu in England became sick. The paper is published in the January 2009 issue of CDC’s journal, Emerging Infectious Diseases.  (Created: 12/29/2008 by Emerging Infectious Diseases)
Date Released: 12/29/2008

Hong Kong Baby Tests Positive For H9 Bird Flu

 

 

# 2605

 

 

Doctors tell us that, on average, adults have roughly 3 `cold & flu-like' respiratory illnesses each year, and children have about 6.    With nearly 7 billion people on this planet, that's probably somewhere between 20 and 30 billion respiratory infections each year.

 

Maybe more.

 

The vast majority of the time, these victims never see a doctor. 

 

Of those that do seek medical help, most will be told they either have a `cold' or the `flu' based on clinical presentation.  

 

Some doctors, particularly in developed countries, may perform a `rapid flu test' in the office, that tells them if the patient has an influenza `A' virus,  but not the type.

 

Comparatively few samples are ever sent to a lab to be identified. 

 

In fact, out of 20 Billion+ respiratory infections that likely occur each year on this planet, fewer than 1 in 10,000 are ever laboratory typed.

 

Last week, here in the US, 3,035 suspected flu specimens were tested in state and CDC labs around the country.   Of those, only 103 tested positive for influenza. 

 

The other 96.6% of the respiratory illnesses were caused by something other than influenza.  

 

Here is the CDC's week 51 summary.

 

flustats

 

 

The surveillance networks here in the United States, in Europe, and in selected parts of Asia and the Pacific are very good at spotting gross trends, but obviously can't catch every atypical influenza that comes down the pike.

 

And so it is somewhat remarkable that, from time to time, we actually hear of cases like the one below; of a patient infected with a rare form of avian influenza.

 

How often it really happens, is unknown.

 

But today's report is the fifth recorded case of a human H9 infection.

 

And all of those have come from Hong Kong or its vicinity (where testing is, admittedly, more likely to occur than in many other regions of the world).

 

 

Hong Kong baby living in China has mild bird flu

The Associated Press

Published: December 30, 2008

 

HONG KONG: A 2-month-old Hong Kong-born infant who lives in China has contracted a mild strain of bird flu, a health official said Tuesday.

 

The baby girl, who contracted the H9 strain of avian influenza, is currently isolated at a local hospital and is in stable condition, Thomas Tsang, controller of Hong Kong's Center for Health Protection, told a news conference.

 

The baby lives with her family in the southern Chinese city of Shenzhen but recently visited a hospital in Hong Kong after showing symptoms, Tsang said.

 

He said health officials in the southern Chinese Guangdong province are trying to determine how she caught the virus.

 

Tsang said Hong Kong has recorded four previous human cases of H9 infections. All patients have fully recovered.

 

 

The list of pathogens that can cause ILI's (`influenza-like Illnesses') includes  adenoviruses, influenza viruses, human metapneumovirus, parainfluenza viruses, respiratory syncytial viruses, and rhinoviruses.

 

And those are just the viruses. 

 

We can add bacterial causes, such as Legionella spp., Chlamydia pneumoniae, Mycoplasma pneumoniae, and Streptococcus pneumoniae as well.

 

And, it seems, we are discovering new culprits all the time.

 

Most of these, even the exotic ones like H9 avian influenza, produce only mild or moderate disease symptoms.   In most cases, victims recover without incident.

 

That, and the fact that they probably occur more often than we know, should be of some comfort to the reader.

 

The concern here is that viruses, particularly single strand RNA viruses like the influenzas, mutate all the time.   They pick up, and discard, genetic bits as they move from host to host, and they make errors in replication. 

 

This happens countless trillions of times every day.

 

Most of the time, these changes go nowhere.  They either have no effect on the virus, or they are evolutionary dead-ends, rendering it less capable of replication and transmission.  

 

Every once in a great while, however, a virus hits the jackpot. 

 

The right combination of genetic changes occurs to make it highly transmissible, and capable of causing significant morbidity and mortality.

 

And if that happens someplace where the virus has a chance to get a foothold (a susceptible population), it can spark an epidemic.

 

 

And sometimes . . . not often, but sometimes . . .  epidemics can turn into pandemics.

 

And so we watch, and our ears perk up, when we hear of a case like today.  Not because this is an earth shattering story, or that it should be cause for alarm.    It really isn't.

 

But because it could be an early warning that something has changed with the H9 virus in China.  That, perhaps, the incidence of it jumping to humans may be increasing.

 

And that is always worthy of our attention.

Monday, December 29, 2008

India: Massive Bird Flu Awareness Campaign Begins

 

# 2604

 

 

 

 

Last winter one of the biggest problems local governments faced during the culling operations was a lack of cooperation by many of the villagers asked to give up their poultry.   

 

Some culling teams were physically attacked.

 

Rather than accept the government' offer of compensation, some people preferred to hide, sell, or trade their chickens  . . . most not believing that their chickens were really sick, or that they  posed any health hazard to humans.

 

This winter, we are once again seeing the same pattern in Assam and West Bengal.  Resistance and a lack of cooperation by villagers has greatly hampered the culling operations in those states.

 

Health officials in India are beginning a major public education campaign, in hopes that some of these problems can be eliminated in the future.

 

This from New Kerala.

 

 

 

Mass awareness campaign on against bird flu

 

New Delhi, Dec 29 : Indian health officials were beginning a mass awareness campaign to prevent recurrence of bird flu after culling of over 400,000 poultry in the two affected states of West Bengal and Assam.

 

As many as 421,057 birds have been culled so far in the two states, health ministry officials said Monday.


“We are creating public awareness by telecasting and broadcasting messages through local channels and All India Radio about avian influenza to check the problem,” an official said.


The official said they were also interacting with village people and spreading awareness by making public announcements in the affected areas.


“We are carrying out intensive campaigning by announcements and also through interactions. This is one way of checking that bird flu doesn't spread to new areas,” he added.


"We are scaling up mopping-up operations in those areas where culling activities have been completed in Assam and West Bengal," the official said.

 

 

 

The announcement, that culling has been completed in Assam and West Bengal, seems to go against yesterday's disclosure that bird flu had appeared in 5 new areas of Assam.  

 

We've seen conflicting reports out of India's press before, along with premature announcements of containment.  

 

And one must differentiate, I suppose, between what they actually mean when they say `culling phase' and `mopping up phase'.

 

In any event, both of these areas deserve close scrutiny over the next few weeks to see if the virus has truly been contained.

Effect Measure On Bird Flu's Birthday

 

 

# 2603

 

 

Given the hype and hoopla sometimes afforded bird flu on the Internet, it is always refreshing to see a more composed analysis of the situation - which is exactly what the Revere's over at Effect Measure have done with:

 

Today is bird flu's birthday

Sunday, December 28, 2008

Assam: Culling Operation Enters 2nd Month

 

 

# 2602

 

 

On November 28th, the news wires began carrying stories of an H5N1 outbreak in poultry in Assam, India.  Local officials were optimistically predicting that roughly 30,000 birds needed culling, and that it would be completed in 3 or 4 days. 

 

 

"The entire culling process is expected to be completed in three to four days as our teams are visiting each and every household in the area. We estimate there could be some 30,000 poultry birds in the area where culling is currently underway," said Manoranjan Choudhury, deputy director of the Assam veterinary department.

 

That was one month, and 500,000 birds ago.   Obviously things have not gone as planned.

 

According to authorities, some villagers are continuing their opposition to the cull, hiding their poultry and occasionally meeting cullers with armed resistance.   

 

New areas in Assam are still reporting sudden bird deaths, and the culling zones are being expanded.   Meanwhile, culling operations are also ongoing in West Bengal.

 

 

This from Indiopia.

 

 

 

Culling continues in Assam, people resist operations


Published: December 28,2008

 

Guwahati , Dec 28 Culling operations continued in some areas of birdflu-hit Assam today but resistance by local people hampered the effort of the authorities to create bird free zones in some areas.

 

Official sources said here that culling operations continued in new areas of Nagaon and Chirang districts with the respective Deputy Commissioners issuing instructions to ensure that the operations did not get hampered.

 

Though the district administration had embarked on an awareness drive to educate the people about the perils of avian influenza and, villagers and poultry farmers opposed culling operation alleging that the compensation offered was not adequate.

 

Despite some opposition, authorities were working to create bird free zones', to contain any spread of the H5N1 virus, in Manahkuchi, Chayani Barduar blocks of Kamrup (rural) district, Tihu, Barama of Baksa, Chachaligaon Burachowk of Nagaon and Rangamati and Aurpakmoniari area of Kamrup (Metro) district.

Saturday, December 27, 2008

Bird Flu Returns To Northern Vietnam

 


# 2601

 

 

image

 

 

Compared to 2007, Vietnam has seen far fewer outbreaks of the H5N1 bird flu virus this year.   They have had 5 fatalities this year, however, and have consistently reported one or two provinces battling the virus throughout the year.

 

As we've seen in the past month - in places like China, India, and Thailand - cooler weather tends to fuel the spread of bird flu.  Officials in Vietnam are publicly expressing concern that more outbreaks may occur over the next few months. 

 

Reuters is reporting today on two new outbreaks in Thai Nguyen city, north of Hanoi.

 

 

 

 

 

 

Bird flu found in poultry in northern Vietnam

Sun 28 Dec 2008, 2:27 GMT

 

HANOI (Reuters) - Bird flu has resurfaced in poultry in northern Vietnam after many months without any cases, killing ducks and chickens at two farms, a state-run newspaper reported on Sunday.

 

Animal health officials confirmed on Saturday the H5N1 virus had killed several birds among a flock of more than 100 ducks in Thai Nguyen city, 80 km (50 miles) north of Hanoi, the Ho Chi Minh City Communist Youth league-run Tuoi Tre newspaper said.

 

Officials had also detected the virus in dead chickens at a farm in the same city and nearly 4,200 chickens had been slaughtered to prevent the virus from spreading, the report said without giving a timeframe.

 

Deputy Health Minister Trinh Quan Huan said this week that there was a very high risk of bird flu returning during the winter and spring in northern Vietnam. The H5N1 strain seems to thrive best in low temperature.

Betting The Farm

 

 

# 2600

 

 

Every once in awhile you read some sad story about someone playing the ultimate game of chance, Russian Roulette, with a loaded revolver.

 

The idea is simple.  Put one bullet in one chamber of a revolver, give it a spin, and then test your nerve (and luck) by putting it to your head and pulling the trigger.

 

With six chambers, the odds are 1 in 6, or about 16.66%, of the `game' ending badly with each spin.

 

Most people would agree that playing Russian Roulette is crazy.  The risks are enormous, and eventually, your luck will run out.   It is hard to think of any reward that would make taking such a risk worth it.

 

Yet millions of business owners, individuals, and families are playing their own version of Russian Roulette every year.  

 

Rather than prepare for a disaster, they literally bet the farm that nothing `really bad' will happen.   And like with Russian Roulette, sometimes their luck holds. 

 

For a while.

 

We're told that the risks of seeing a pandemic are increasing with each year.  Quantifying that risk is difficult, of course.   No one really knows how likely it is that a pandemic will occur in the short term.  

 

But long term?  Say, over the next 10 years?

 

The odds are pretty good that a pandemic will happen. Probably a lot better than 1 in 6.

 

Add in the odds that something other than a pandemic, like an earthquake, or a tornado, or a hurricane will strike, and the odds that you your business, or your family will face a disaster sometime in the next 10 years go even higher.

 

Instead of just one bullet occupying one chamber, there may be two bullets, or even three in this `gun'.

 

With those odds, you'd have to be crazy not to prepare, wouldn't you?

 

We've managed to get through 2008 without a global disaster.  But we saw many regional crises. FEMA has declared 75 Major Disasters in the United States this year alone.  Wildfires, flash floods, hurricanes, blizzards . . .

 

Literally millions of people were affected by these disasters.  And hundreds of thousands of businesses.   

 

Of course, most people were lucky this year.  Their lives weren't touched by a serious crisis.

 

Maybe their luck will hold out in 2009.  Maybe not.

 

The Federal government wants you, your family, and your business to be prepared.   They know that that bad things happen all the time, and that being prepared is the best insurance policy of all.

 

Ready America logo

 

They urge you to GET A KIT, MAKE A PLAN, and to BE INFORMED.

 

The government wouldn't be spending the kind of resources they do each year touting preparedness if they didn't think it was worth doing.

 

Every family, and every business, needs a COOP - or Continuity Of Operations Plan.  Governments do it, Fortune 500 businesses do it, and so should you.

 

There are many degrees of preparedness, of course.   At the very least, every family should have 3 days worth of food and water on hand, along with flashlights, a first aid kit, and a battery operated radio.   

 

But that is just the start of what needs to become a culture of preparedness in our country, and around the world.

 

Once you have the basic 72 hour kit in place, it is time to start working on a 2-week kit.   And once you've reached 2-weeks, it is time to look beyond that.

 

Given the uncertainties that the future holds, it only makes sense to make 2009 the year that you, your family, and your business becomes better prepared to face an emergency.

 

A few good places to get started are:

 

FEMA http://www.fema.gov/index.shtm

READY.GOV http://www.ready.gov/

AMERICAN RED CROSS http://www.redcross.org/

 

 

For Pandemic Preparedness Information: HHS Individual Planning Page

 

For more in-depth emergency preparedness information I can think of no better resource than  GetPandemicReady.Org.   

 

Site Meter

 

Admittedly, as a minor contributor to that site, I'm a little biased.

 

But whether you are preparing for a hurricane, an earthquake, a pandemic, or a terrorist attack - the important thing is not to delay.  

 

Ready or not, the next disaster will likely come with very little warning.

Friday, December 26, 2008

WHO Updates the Cholera and Ebola Situations In Africa

 

 

# 2599

 

 

Two WHO (World Health Organization) updates today, December 26th.   This first one is on the ongoing Cholera epidemic in Zimbabwe, which is encroaching into South Africa.  

 

This is the same epidemic that incredibly, Zimbabwe President Mugabe declared to be over two-weeks ago,   stating. "I am happy to say our doctors have been assisted by others and WHO [the World Health Organization] ... so now that there is no cholera."

 

 

 

 

Cholera in Zimbabwe - update

 

26 December 2008 -- As of 25 December 2008, a total of 26 497 cases, including 1 518 deaths, have been reported by the Ministry of Health in Zimbabwe. Cases are now being reported from all 10 of the country's provinces. Harare, particularly Budiriro suburb in the south west, accounts for the majority of cases, followed by Beitbridge in Matabeleland South and Mudzi in Mashonaland East. The current outbreak is the largest ever recorded in Zimbabwe and is not yet under control. In fact, the epidemiological week ending 20 December saw over 5 000 new cases - an increase in the number of weekly cases relative to previous weeks - and an increase in deaths outside treatment/health centres.

 

The overall Case Fatality Rate (CFR) has risen to 5.7% - far above the 1% which is normal in large outbreaks - and in some rural areas it has reached as high as 50%. Mortality outside of healthcare facilities remains very high. This is a clear indication that better case management and access to healthcare is needed - in particular an increased use of oral rehydration therapy with Oral Rehydration Salts in communities very early after onset of the disease.

 

The outbreak has taken on a subregional dimension with cases being reported from neighboring countries. In South Africa as of 26 December, 1 279 cumulative cases and 12 deaths (CFR of 0.9%) had been recorded, with the bulk of the cases (1 194) in the Limpopo area. Cases have also been reported in Botswana (Palm Tree).

 

The current situation is closely linked to the lack of safe drinking water, poor sanitation, declining health infrastructure, and reduced numbers of healthcare staff reporting to work. Other current risk factors include the commencement of the rainy season and the movement of people within the country, and possibly across borders, during the Christmas season.

 

WHO, together with the Ministry of Health and partners from the health and Water and Sanitation clusters, has established a cholera outbreak response coordination unit in order to strengthen the reporting and early detection of cases, improve the response mechanism and access to healthcare and ensure proper case management. WHO has also deployed experts in public health, water and sanitation, logistics and social mobilization. In light of the extent and pace of expansion of the outbreak, reinforcing all control activities across the country is critical.

 

Given the current dynamic of the outbreak and the context of the collapsed health system, a cholera vaccination is not recommended. Moreover, the use of the internationally available WHO prequalified oral cholera vaccine is not recommended once an outbreak has started due to its 2-dose regimen and the time required to reach protective efficacy, high cost and the heavy logistics associated to its use. The use of the parenteral cholera vaccine has never been recommended by WHO due to its low protective efficacy and the occurrence of severe adverse events.

 

In controlling the spread of cholera WHO does not recommend any special restrictions to travel or trade to or from affected areas. However, neighboring countries are encouraged to reinforce their active surveillance and preparedness systems. Mass chemoprophylaxis is strongly discouraged, as it has no effect on the spread of cholera, can have adverse effects by increasing antimicrobial resistance and provides a false sense of security.

 

 

Today's other update is on the Ebola outbreak in the Congo.

 

Ebola haemorrhagic fever in the Democratic Republic of the Congo

 

26 December 2008 -- The Ministry of Health (MoH) of the Democratic Republic of the Congo declared on 25 December an outbreak of Ebola haemorrhagic fever in Mweka District, Kasai Occidental province based on laboratory results from the Centre International de Recherches Médicales de Franceville (CIRMF) in Gabon. CIRMF confirmed the presence of Ebola virus in 2 samples from 2 of the patients in the outbreak by antigen detection. In addition, laboratory tests conducted by Institut National de Recherches Biologiques (INRB) in Kinshasa, also confirmed the presence of Shigella.

 

As of 26 December, WHO is aware of 34 suspected cases including 9 deaths (CFR 26%) associated with the ongoing event. Additional samples have been collected and are en route to INRB.

 

The WHO Country Office, Regional Office and Headquarters are supporting the MoH in Kinshasa and in the field at the location of the outbreak. In addition, the WHO Country Office is supporting the operational costs of the investigation and response teams and has deployed four vehicles to the field. Additional staff, outbreak response equipment and supplies, including Personal Protective Equipment (PPE), are also being sent to the area. An enhanced team of national and international experts is being mobilized to implement control strategies for Ebola haemorrhagic fever and to support outbreak field response in the province.

 

WHO is working together with laboratory partners to provide comprehensive laboratory services, and to support the MoH in the control and investigation of the outbreak.

 

WHO is unaware of any reports signaling the international spread of disease and advises against the application of any travel or trade restrictions upon the Democratic Republic of the Congo .

Australia's Concerns Over Emerging Infectious Diseases

 

# 2598

 

 

A year hardly passes when we don't learn of some new, often deadly disease affecting mankind.  Most of these new diseases are zoonotic, diseases primarily of animals, that have jumped to humans.

 

SARS, which appeared in November of 2002, and swept the world during the first half of 2003, came from the penchant of some Chinese to dine on exotic animals.  These animals were slaughtered, and served, in `Wild Flavor' restaurants, particularly in Guangdong Province.

 

A previously unknown coronavirus, which subsequently was discovered in civet cats served in these establishments, was determined to be the likely cause of the SARS outbreak.  

 

The close proximity of infected wild animals to humans had allowed the virus to jump species - and the result was the infection of more than 8,000 people, and the deaths of more than 800.

 

This is precisely the kind of scenario that we worry about today with close human contact to birds carrying various avian influenza viruses. The H5N1 virus is our primary concern, but it isn't the only one out there.   The H7 and H9 viruses also have pandemic potential, along with others we don't even know about.

 

In recent years we've seen the emergence of the Nipah Virus in Malaysia, and the Hendra virus in Australia.    Many of these viruses seem to emerge from China and other parts of South East Asia.

 

This, quite naturally, is a major concern to Australia.

 

This is a press release from the Australian Biosecurity Cooperative Research Centre for Emerging Infectious Disease (AB-CRC), along with a link to their full report.

 

 

 

'Ring of fire' disease threat to Australia's north
Friday, 26 December 2008

Media Release

For immediate release

Full public report available (PDF file; 192kb)

‘Ring of fire’ disease threat to our north

Australia is surrounded to its north by a ‘ring of fire’ where new human and animal plagues are likely to erupt without warning, with potentially devastating consequences.

 

“A study by one of our partners has revealed a number of global hot-spots where new and unknown diseases are most likely to erupt – and it turns out that one of the hottest is spread in an arc to Australia’s north,” says Australian Biosecurity Cooperative Research Centre for Emerging Infectious Disease (AB-CRC) chief executive officer Dr Stephen Prowse.

 

“We’re in the front line for outbreaks of diseases like SARS, bird flu, Nipah virus, enterovirus 71 and chikungunya – which infect both people and animals. Such diseases are most likely to emerge in our region,” Dr Prowse says.

 

The study highlights the vital importance of developing and maintaining effective disease surveillance in our region – as often the only defence against a new disease is to spot it early, before it spreads. However it also offers scope to anticipate where new plagues could arise.

 

The study of global disease hot-spots was carried out by Dr Peter Daszak and colleagues of the Consortium for Conservation Medicine in New York, a partner of the AB-CRC.

 

“We’ve developed an ‘earthquake zone’ map for emerging diseases. It shows which countries are most likely to be on the front line of an emerging pandemic. We now have a way to predict the places from where the next HIV, SARS or avian influenza is likely to emerge,” Dr Daszak says.

 

“Our risk map shows that Australia is surrounded to the north by a ‘ring of fire’ – countries that are some of the hottest of the hot-spots. This means Australia needs to be forward thinking in its approach to biosecurity risk.”

 

And that is exactly what we are doing, says AB-CRC CEO Dr Prowse. “The map is fascinating because of what it tells us of the probability of new diseases emerging or of old diseases – like rabies for example – re-emerging.  It also invites us to think much more creatively about how we go about preventing them.”

 

Instead of relying on a handful of overworked professional doctors and vets spread across an enormous area to spot new plagues, Dr Prowse believes Australia can help to develop a regional “neighbourhood watch” involving farmers, teachers, other healthcare professionals and even ordinary citizens on the lookout for unexplained sickness or deaths in animals or people.

 

“New and emerging diseases rarely have any form of treatment and death rates can be quite high – as in the case of Nipah virus which kills about half of those who contract it,” he says. “The best course is to stamp out the bushfire before it takes hold and spreads.”

 

The importance of early detection and diagnosis is paramount, he adds. “The rapid diagnosis test developed by our partners was very important in helping to eradicate equine influenza (EI) in Australia following the recent outbreak. We played a critical part in getting the test into the major veterinary laboratories in the country. This meant that it was possible to quickly establish if the disease was present or not and take the proper steps to contain and eradicate it.”

 

EI was a warning of what can happen when a major disease gets loose, whether among humans or livestock, he says.

 

Meanwhile some old pestilences are emerging anew: bluetongue is spreading again in Europe –- possibly due to climate change,  - rabies is on the comeback in Bali, and foot-and-mouth disease remains a huge problem in many regions of South-East Asia.

 

The Asian tiger mosquito – a feared carrier of several deadly diseases – is spreading worldwide due to trade and possibly climate change. “It’s a genuine barbecue-stopper,” says Dr Prowse. “It can carry deadly diseases like dengue fever and chikungunya.”

 

That Australia has unknown diseases of its own was graphically shown in recent cases of Hendra virus and Bungowannah virus. Also koalas are being wiped out in record numbers by a new retrovirus.

 

The current state of the disease threat to Australia and its main events over the past twelve months is outlined in a new public report by the AB-CRC. (PDF file; 192kb)

Vietnam Issues Bird Flu Advisory To All Health Depts

 

# 2597

 

 

The recent upswing in the reporting of H5N1 outbreaks around the world hasn't gone unnoticed in Vietnam.   The Winter and Spring have historically been periods of high virus activity, and so warnings have been sent out to all Health Departments to be prepared.

 

This from the Voice of Vietnam News.

 

 

 

 

 

Updated : 11:32 AM, 12/26/2008

Ministry issues bird-flu instruction

 

The Ministry of Health has instructed to intensify avian flu prevention measures at all health departments in 63 provinces and cities.

 

The instructions followed the recent development of the H5N1 virus among both birds and humans, the ministry’s Administration of Preventive Medicine and Environmental Health (APMEH) director Nguyen Huy Nga said on December 25.

 

All these provinces and cities were asked to implement epidemic control where avian flu had been found in poultry and strive for the early detection of suspected H5N1 infection to ensure immediate quarantine and control, he said.

 

There should be strict control of visitors arriving through border gateways from places where avian flu had occurred was also sought.

 

Health ministry figures show that five people have been infected with the H5N1 virus this year and all died. Although the last death was in April, scientists warn that the deadly virus could return.

 

Vietnam has diagnosed 106 H5N1-infected patients in 36 provinces and cities since the virus was first reported in December 2003. Of these, 52 died.

Assam: Despite Culling, Bird Flu Continues To Spread

 

 

# 2596

 

 

The H5N1 virus, once it becomes entrenched in a region, has historically been very difficult to eradicate.  

 

Vietnam, the poster-child for aggressive bird flu containment policies, continues to fight an ongoing battle against the virus more than six years after it first erupted.   

 

Exactly why the virus tends to return to an area isn't known. 

 

Is it re-introduced by migratory birds, or by illicit poultry trade?   Or does the virus hide in indigenous asymptomatic birds in the area?  Or are there perhaps other, non-avian, reservoirs out there giving the virus a safe `off-season' habitat?

 

Unfortunately there are a great many things that we don't know about influenza viruses in general, and the H5N1 virus in particular.

 

In the article below, a lakh refers to 100,000.   So 500,000 birds have been culled in Assam state thus far.   One hundred and fifty villages have reported  outbreaks.

 

Even as officials were declaring the culling operation over, with only `mopping up' to do, new reports of bird deaths were coming in.  

 

New culling zones are being established.

 

This from  Zeenews.

 

 

Bird flu spreads to new places in Assam

 

Guwahati, Dec 26: Bird flu has spread to new areas in Assam where culling of poultry has been going on since November 27.

 
Over five lakh chicken and ducks have been culled in the state. Sources in the Animal Husbandry and Veterinary Department said cases of fresh bird flu attack were reported at Manahkuchi of Hajo and Chayani Barduar block in Kamrup (Rural) district, where the disease was first detected.


Other fresh areas to be hit by the virus are Tihu- Barama of Baksa district, Chachaligaon Burachowk village in Nagaon district, Rangamati, Aurpakmoniari Tiniali in Kamrup (Metro) district and Doloigaon Uzanpara in Bongaigaon district, the sources said.


Culling operations were initiated in the three-km radius area of the new bird flu-hit notified centres, while it continued in the previously notified areas.


With seven new locations notified, so far 19 epicentres were officially stated to be affected by avian flu in seven districts of Assam.


Nearly 150 villages have been declared bird flu-hit, for which 1,720 rapid response teams were deployed.


Almost two lakh eggs and 14,000 kg of bird feed have been destroyed since the beginning of culling.


Culling, mopping and disinfection operations were completed in nine centres of Kharghuli and Khanapara in Guwahati, Dibrugarh town, Rajabazar, Sarpara, Patgaon, Kathla, Katajhar and Bejerajalah.


Residents of Nalibari village in Chirang district resisted culling operations but veterinary officials were confident of convincing them to allow the anti-bird flu operation.


Compensation worth Rs 1.35 crore had so far been paid to the poultry owners, the sources said.


The affected districts are Kamrup (Metro), Kamrup (Rural), Nalbari, Barpeta, Chirang, Dibrugarh and Bongaigaon.
Bureau Report

Thursday, December 25, 2008

Ebola Outbreak Confirmed In The Congo

 

# 2595

 

 

 

This is a story we've been watching for about 5 days.   On 12/20 the following report hit the newswires (hat tip Dutchy on Flutrackers). 

 

Hemorrhagic fever blamed for 9 deaths in Congo
12/20/2008 |


KINSHASA, Congo - Medical authorities in Congo say nine people are dead from what could be hemorrhagic fever.


District Medical Inspector Edmond Mulamba says it is too early to label the illness. It is also too early to say if the deaths are due to ebola, a type of hemorrhagic fever.


He says tests were being run to determine the cause of the deaths in remote Kasai Province. At least 14 other people are suffering from symptoms of hemorrhagic fever, including high temperature and violent vomiting.


Mulamba says a team of doctors from the World Health Organization are traveling to the province.


Last year, at least 167 people died of ebola in the same district where the current illness is being reported, around 400 miles (700 kilometers) southeast of Congo's capital, Kinshasa. -

 

Since then, we've received a number of reports, and the indications are that this outbreak began in late November, in a remote area 400 miles to the South East of the Capital.

 

Today, via a machine translation of an AFP report in French (hat tip, Florida1 at Flutrackers), we get confirmation that this is indeed Ebola.

 

 

 

 

 

 

New Ebola outbreak in DRC: nine deaths and 21 patients identified

 

KINSHASA (AFP) - A new Ebola epidemic broke out in the center of the Democratic Republic of Congo (DRC), killing nine people and 21 patients identified, said Thursday Radio Okapi, citing the Congolese Minister of Health Augustine Mopipi.

 

This epidemic has emerged in the town of Kampongo to more than 60 km from Mueka in the province of Kasai Occidental (center), said the minister stressed that the analysis of samples taken on site have confirmed the existence of the Ebola haemorrhagic fever.

 

Highly contagious disease, fatal in 50 to 90% of cases, Ebola had struck the former Zaire on three occasions.

 

In 1976, the virus has killed nearly 500 people on both sides of the border between Sudan and north-eastern Zaire, where he resurfaced in 1995, with 245 deaths in the Bandundu province (west).

 

In 2007, 26 confirmed cases of Ebola had been registered in the province of Kasai Occidental, where several outbreaks associated (Ebola, typhoid fever, malaria, dysentery) killed 187 people.

Egypt: Family of Five In Isolation

(UPDATED) 

 

# 2594

 

 

A big hat tip to Florida1 on Flutrackers for picking up this story from the Arabic Press (finding bird flu stories in Arabic isn't easy!). 

 

 

The article relates that a 45 year old associate veterinarian, his wife, and three sons are in isolation in a hospital ward devoted to suspected bird flu cases.  They are on Tamiflu (Altamflo), and blood samples have been drawn for testing.

 

 

No city of origin is given, which is unusual. 

 

 

 

 

Family of suspected infection


5 members from bird flu

West - Ali Oboudecic:

Hospital admitted yesterday detained Mahala Fathi Abdul Sattar, "45 years" associate veterinarian, "and his wife and his three sons" in the section devoted to cases of suspected bird flu, after the emergence of symptoms of high temperature and severe pain, severe cough and joints, where the drug was given and the withdrawal of Altamflo a sample of blood sent to the laboratory and the central Ministry of Health.

 

It also has a committee of veterinary medicine to death more than a dozen ducks were Bhzirp the house and cleaning up the place and the imposition of Kerdoun security until the arrival of the results of tests to determine the extent of the injury or not.

 

 

The last paragraph is a bit confusing, as happens often in these machine translations.  It appears to indicate some sort of culling of ducks, but exactly when this occurred, and its relationship to these suspect cases isn't readily apparent.

 

 

UPDATE 12:40 ET

 

In what appears to be a separate case, we have another news article in the Arab press (hat tip, again, Florida1) regarding a 35 year-old hospitalized, suspected of having the H5N1 bird flu virus.

 

A new suspected case of bird flu in the lake

البحيرة ـ تامر عبدالرءوف‏:‏

Tamer Abdul Rauf, the lake:

للاشتباه في إصابته بإنفلونزا الطيور‏,‏ تم حجز عبدالله منجد إبراهيم‏35‏ سنة من قرية منشية مهنا بكوم حمادة بمستشفي حميات الإسكندرية بعد ظهور أعراض الإصابة بالمرض عليه‏.‏ ونظرا لمخالطته الطيور التي تربيها زوجته أعلي سطح منزله‏,‏ اشتبه الأطباء في حالته وتم تحويله إلي حميات الإسكندرية وأخذ عينات منه وإرسالها إلي المعامل المركزية بوزارة الصحة‏.‏

 

On suspicion of having bird flu, has been reserved Munjid Abdullah Ibrahim, 35, from the village of Kom Hamada Manshiyat Mihanna fevers Alexandria hospital after the emergence of the symptoms of the disease. In view of the coming flu, which has kept his wife, the highest roof of his home, doctors suspected in his case was transferred to Alexandria, admitted taking samples and sending them to labs central Ministry of Health.

 

This, like the others, is just a suspect case.

 

Last year, you may remember, between December 25th and January 1st, 4 Egyptian women died from the H5N1 virus.  

 

Egypt, however, has tested thousands of suspected cases, and of those, only 51 have tested positive for the virus.

Wednesday, December 24, 2008

Japan: Local Governments Slow To Prepare For A Pandemic

 

# 2593

 

 

 

Despite strong indications that the national government of Japan takes the pandemic threat very seriously, we continue to see little evidence of that mind set filtering down to the private sector, or to  local governments

 

Earlier this year a think tank sent out a preparedness questionnaire to 4,000 listed companies asking about their preparedness for a pandemic.  

 

Out of 4,000 questionnaires sent only 448 companies, or about 11%, chose to respond.  Of those, according to the InterRisk Research Institute & Consulting Inc. survey, only 48% said they either had a pandemic plan, or had plans to formulate one.

 

For more details, see Japan: A Dearth Of Preparedness.

 

Today, in an article in Japan's Daily Yomiuri, we learn that the level of preparedness among local government entities appears to be no better.

 

Not that Japan is alone in this. 

 

I doubt that the level of preparedness in most nations is any better.   Even companies, agencies, and municipalities that have pandemic plans, often fail to test, and revised them.   

 

Having a plan isn't enough, of course. It has to be a good plan, based on reasonable assumptions. 

 

And you have to test the plans, regularly.

 

 

A hat tip to Shiloh on Flutrackers for posting this article.

 

 

 

Study: Local govts lack sense of urgency on flu

The Yomiuri Shimbun

(Dec. 25, 2008)

 

Only 6 percent of municipalities across the country have prepared for a possible outbreak of a new type of influenza, by taking such measures as working out contingency plans and setting up emergency drills, a Health, Labor and Welfare Ministry research team has revealed.

 

Their study also found that only about 20 percent of municipalities had set up systems to fight a potential outbreak in cooperation with medical institutions and emergency teams, a sign that local governments lack a sense of urgency over the issue.

 

The study was conducted by post in August, surveying 1,787 local governments and Tokyo's 23 ward governments about their flu-related contingency projects, with 1,188 governments, or about 70 percent, responding.

 

Only 68 governments, or about 6 percent, said they had mapped out action plans in preparation for a possible outbreak of a new strain of influenza, while only 74 governments had conducted drills to deal with a flu pandemic.

 

About 12 percent of governments said they were working on creating action plans, while 65 percent said they have not considered any plans.

 

Asked if they had any system to coordinate with medical institutions, 11 percent said they did, while another 11 percent said they had done so "to a certain extent."

 

About 24 percent of local governments have set up systems for cooperating with fire departments in charge of emergency and rescue missions. Only 15 percent have established systems for working with virus-testing institutions, even though such facilities are vital for detecting a new flu strain and in preventing its spread.

 

Asked for reasons for the delay in preparing countermeasures, 36 percent said they did not know what kind of measures a local government should take.

 

About 19 percent responded that the central government's countermeasures are not clear enough, while 15 percent said they lacked funds for such projects.

 

Meanwhile, 11 percent said the level of attention to the issue was low in their governments.

 

In 2005, the central government created an action plan to combat a new flu pandemic. Since then, prefectural governments have mapped out their own plans at the request of the central government.

 

However, decisions on possible countermeasures against a flu outbreak in each region have been up to local governments.

(Dec. 25, 2008)

When Viruses Jump Species

 

# 2592

 

 

Viruses generally adapt to a fairly narrow range of species.  Horse viruses generally attack equines, and not say, cats and dogs.   Cat viruses tend to attack felines, and not birds.   Bird viruses usually only infect avian species.

 

The species that a virus will infect is known as its host range.  And while usually limited, it isn't always the case.  Rabies is a good example of a virus that can infect a wide host of species.

 

We know that every once in awhile, viruses do jump to a new species.  Canine influenza is caused by a recent species jump from an equine influenza virus , and that is exactly what we are seeing with the H5N1 bird flu virus over the past decade.  

 

We've  seen H5N1 infections in cats (including tigers), dogsmartens, civets, and of course humans. Researchers have successfully infected cattle with the H5N1 virus, along with ferrets and mice for testing.

 

So what was once purely an avian virus has now expanded its host range to include a variety of mammals, some of which appear to be able to carry the virus asymptomatically - while others manifest serious, often fatal symptoms.   

 

If the H5N1 virus had not shown the ability to jump species, we would probably just consider it another fowl plague.  A costly nuisance for the poultry industry, but not a danger to humanity.

 

In recent weeks we've been hearing about a new species jumping event,  and the implications of this aren't immediately obvious.  In the Philippines, pigs have been found to carry the Ebola Reston virus.

 

image

 

 

Ebola-Reston virus is a filovirus with genetic characteristics similar to the deadly Ebola Zaïre, but unlike its deadly African cousin, this Asian strain has never been shown to cause disease in humans.  

 

It can be fatal in simians, however.

 

This new strain of Ebola  was first discovered in crab-eating macaques, imported from the Philippines, at a research laboratory in Reston, Virginia (USA) in 1989.   This discovery was recounted in the book, The Hot Zone, by Richard Preston.

 

While humans could apparently be infected, and develop antibodies to the virus (3 researchers in Reston developed high antibody titers to the virus), all have reportedly been asymptomatic.

 

Of course, the concern is that viruses have a nasty habit of mutating.  What was true yesterday may not be true tomorrow.

 

Since pigs and humans share many commonalities in their physiology (if that induces discomfiture in you, think how the pig feels) any disease that jumps to swine is of immediate concern to scientists.   Which is why the WHO/FAO and OIE are all vitally interested in the reports coming out of the Philippines of pigs infected with Ebola Reston.

 

Of course, there are many diseases of swine that  humans are not susceptible to, such as Porcine reproductive and respiratory syndrome (PRRS). 

 

For now, this is pretty much just a fascinating medical mystery. There doesn't appear to be any immediate biological threat to humans from this outbreak of Ebola Reston in swine.   

 

But it is a truism in science that you never know where research will lead you.  Anything that expands our knowledge on how viruses jump species, mutate, or spread could prove invaluable later on down the line.

 

 

This update from the FAO newsroom.

 

 

 

 

First detection of Ebola-Reston virus in pigs

23-12-2008

FAO/OIE/WHO offer assistance to the Philippines

Manila/Roma, 23 December 2008 - Following the detection of the Ebola-Reston virus in pigs in the Philippines, FAO, the World Organization for Animal Health (OIE) and the World Health Organization (WHO) announced today that the government of the Philippines has requested the three agencies send an expert mission to work with human and animal health experts in the Philippines to further investigate the situation.

 


An increase in pig mortality on swine farms in the provinces of Nueva Ecija and Bulacan in 2007 and 2008 prompted the Government of the Philippines to initiate laboratory investigations. Samples taken from ill pigs in May, June and September 2008 were sent to international reference laboratories which confirmed in late October that the pigs were infected with a highly virulent strain of Porcine reproductive and respiratory syndrome (PRRS) as well as the Ebola-Reston virus.


 

Ebola-Reston in swine

Although co-infection in pigs is not unusual, this is the first time globally that an Ebola-Reston virus has been isolated in swine. It is not, however, the first time that the Ebola-Reston virus has been found in the Philippines: it was found in monkeys from the Philippines in outbreaks that occurred in 1989-1990, 1992, and 1996.


 

The Ebola virus belongs to the Filoviridae family (filovirus) and is comprised of five distinct species: Zaïre, Sudan, Côte d'Ivoire, Bundibugyo and Reston. Zaïre, Sudan and Bundibugyo species have been associated with large Ebola hemorrhagic fever (EHF) outbreaks in Africa with high case fatality ratio (25-90%) while Côte d'Ivoire and Reston have not. Reston species can infect humans but no serious illness or death in humans have been reported to date.


 

Since being informed of this event in late November, FAO, OIE and WHO have been making every effort to gain a better understanding of the situation and are working closely with the Philippines Government and local animal and human health experts.

 

The Department of Health of the Philippines has reported that initial laboratory tests on animal handlers and slaughterhouse workers who were thought to have come into contact with infected pigs were negative for Ebola-Reston infection, and that additional testing is ongoing. The Bureau of Animal Industry (BAI) of the Philippines Department of Agriculture has notified the OIE that all infected animals were destroyed and buried or burned, the infected premises and establishments have been disinfected and the affected areas are under strict quarantine and movement control. Vaccination of swine against PRRS is ongoing in the Province of Bucalan. PRRS is not transmissible to humans.

 


The planned joint FAO/OIE/WHO team will work with country counterparts to address, through field and laboratory investigation, important questions as to the source of the virus, its transmission, its virulence and its natural habitat, in order to provide appropriate guidance for animal and human health protection.


 

Basic good hygiene


 

Until these questions can be answered, the FAO and WHO stressed the importance of carrying out basic good hygiene practices and food handling measures.

 

Ebola viruses are normally transmitted via contact with the blood or other bodily fluids of an infected animal or person. In all situations, even in the absence of identified risks, meat handling and preparation should be done in a clean environment (table top, utensils, knives) and meat handlers should follow good personal hygiene practices (e.g. clean hands, clean protective clothing). In general, hands should be regularly washed while handling raw meat.

 

Pork from healthy pigs is safe to eat as long as either the fresh meat is cooked properly (i.e. 70°C in all part of the food, so that there is no pink meat and the juices run clear), or, in the case of uncooked processed pork, national safety standards have been met during production, processing and distribution.

 

 

Meat from sick pigs or pigs found dead should not be eaten and should not enter the food chain or be given to other animals. Ill animals should be reported to the competent authorities and proper hygiene precautions and protection should be taken when destroying and disposing of sick or dead pigs. The Philippines Department of Agriculture has advised the Philippine public to buy its meat only from National Meat Inspection Services certified sources.

 

As a general rule, proper hygiene and precautionary measures (wearing gloves, goggles and protective clothing) should also be exercised when slaughtering or butchering pigs. This applies both to industrial and home-slaughtering of pigs. Children and those not involved in the process of slaughtering should be kept away.

Tuesday, December 23, 2008

Low Pathogenic Bird Flu Found In Belgium

 

# 2591

 

 

 

image

 

 

 

Last week it was Germany, yesterday it was Denmark.  Today Belgium is reporting low pathogenic H5 bird flu has been found on two farms in the north part of the country.

 

While a reportable disease, low pathogenic H5 viruses aren't considered to be a human health risk.   Low path viruses do, however, have the potential to mutate into more dangerous highly pathogenic strains - hence the swift action to eradicate it whenever it is discovered.

 

 

 

 

 

 

Bird flu detected in Belgian farms

 

www.chinaview.cn 2008-12-24 05:06:18

    BRUSSELS, Dec. 23 (Xinhua) -- Emergency measures have been taken after an outbreak of bird flu was detected in two farms in northern Belgium, Belgian media reported on Tuesday.

 

    Control tests showed last Friday that some ducks and geese in a farm in Bocholt, which borders the Netherlands, were infected with the H5 bird flu virus. The same virus was also detected in a farm in Buggenhout in the province of East Flanders.

 

    The H5 virus is not dangerous to human beings and is different from the H5N1 variant, which has killed more than 200 people since it surfaced in 2003.

 

    The Belgian Federal Food Agency, which supervises the safety of the food chain, has ordered emergency measures to be taken in the two farms and surrounding areas.

 

    Some 5,000 animals had to be slaughtered as a precautionary measure and all poultry within a radius of one kilometer of the farms must be kept indoors. Transport of poultry is forbidden for 21 days.

Crof's Holiday Greetings

 

 

# 2590

 

 

Crawford Kilian, over at Crofsblog, has a special holiday message to all of flublogia.    If you haven't seen it yet, scoot on over now.

 

I'll wait.

UK: Flu Hits Early This Year

 

 

# 2589

 

 

While reports of seasonal influenza are just now starting to trickle in here in the United States, the UK has already been hit hard by the flu. Young adults, reportedly, are being hit the hardest, with an infection rate 3 times higher than their parents.

 

With the peak of the Flu season here in the United States still more than a month away, it isn't too late to get a flu shot this year.   Vaccine supplies are still ample in most areas.

 

Don't get the flu.  Don't spread the flu.  Get Vaccinated. www.cdc.gov/flu

 

With the increasing resistance of the H1N1 seasonal flu strain to oseltamivir (Tamiflu), getting a flu shot this year makes even more sense.

 

 

This report from the Independent.

 

Young adults suffer most in flu outbreak

 

Older people more likely to be vaccinated, experts say

By Steve Connor, Science Correspondent
Tuesday, 23 December 2008

 

Young adults are being struck down with the flu at three times the rate of their parents' generation, figures from heath watchdogs reveal.

 

For every 100,000 people aged 15 to 44 in England, 54.4 of them have the flu, compared with 18 cases among the same number of people aged over 65.

 

Doctors have been diagnosing more cases of flu during this year's lead-up to Christmas than they have done during the past 10 pre-Christmas periods. The overall rate stands at 39 cases of influenza per 100,000 people within the general population, the government's Health Protection Agency said.

 

The number of flu cases reported to GPs has already breached the minimum "baseline" figure that marks the point at which the outbreak is defined as seasonal but it is still well short of the 200 cases per 100,000 that turn an outbreak into an epidemic.

 

Health experts said the rise in cases among the young, particularly in southern England, was in part due to the fact that many had not received the flu vaccine to protect them against the different strains of the illness.

 

And they said that flu outbreaks often affected certain demographics differently. They suggested that young working people suffering from the early symptoms of flu stay at home, rather than risk spreading the virus through their workplace.

 

(Continue . . .)