Tuesday, September 02, 2014

WHO: Virological Analysis Shows `No Link’ Between DRC and West African Ebola Outbreaks



# 9028


Actually this doesn’t come as a big surprise, but it does lay to rest an earlier report that suggested the DRC Ebola species was some sort of unusual  `hybrid’ between Ebola Zaire and Ebola Sudan. In fact, the outbreak in the Democratic Republic of Congo has now been identified as Ebola Zaire – and an older lineage at that – being most closely related to a strain that was seen in Kitwit, nearly 20 years ago.

Although the West African outbreak is also Ebola Zaire, it is of a different lineage, and therefore not connected to the DRC outbreak.

Ebola is endemic in the DRC (formerly The Republic of Zaire), and has caused at least 8 outbreaks in that region since the virus was first discovered in 1976.  The 1995 Kitwit outbreak infected 315, and killed 250 (81%). While the current outbreak is in a remote area, hindering its ability to spread, the WHO warns that this outbreak needs to be carefully monitored.


This report posted this morning from the World Health Organization.


Virological analysis: no link between Ebola outbreaks in west Africa and Democratic Republic of Congo

Situation assessment - 2 September 2014

Results from virus sequencing of samples from the Ebola outbreak in the Democratic Republic of Congo (DRC) were received last night. The virus is the Zaire strain, in a lineage most closely related to a virus from the 1995 Ebola outbreak in Kikwit, DRC.

The Zaire strain of the virus is indigenous in the country. Ebola first emerged in 1976 in almost simultaneous outbreaks in the Democratic Republic of Congo (then Zaire) and South Sudan (then Sudan).

Confirmatory testing was done at Gabon’s Centre International de Recherches Médicales in Franceville, a WHO collaborating centre. Earlier, testing in DRC confirmed Ebola in 6 of 8 samples.

The outbreak is located in the remote Boende district, Equateur province in the north-western part of the country.

Results from virus characterization, together with findings from the epidemiological investigation, are definitive: the outbreak in DRC is a distinct and independent event, with no relationship to the outbreak in west Africa.

As the Gabon laboratory report clearly stated, “the virus in the Boende district is definitely not derived from the virus strain currently circulating in west Africa.”

These findings are reassuring, as they exclude the possibility that the virus has spread from West to Central Africa.

Epidemiological investigation has linked the index case, who died on 11 August, to the preparation of bushmeat for consumption.

This is the country’s seventh Ebola outbreak since 1976. The introduction of the virus into the human population following contact with infected bushmeat (usually fruit bats or monkeys) is consistent with the pattern seen at the start of previous outbreaks. The virus is now spreading from person to person.

The response team has, to date, identified 53 cases consistent with the case definition for Ebola virus disease, including 31 deaths. Seven of these deaths were among health care workers. More than 160 contacts are being traced.

The government has rapidly mounted a robust response by reactivating emergency committees at national, provincial, and local levels, setting up isolation centres, and providing community leaders with facts about the disease. The government will ensure that all burials are safe.

The WHO team confirmed that collaboration between the government and its key partners is excellent.

The outbreak zone, where the most intense transmission is occurring, is remote, located some 1200 kilometres from the capital city, Kinshasa. No paved roads run from the outbreak zone to Kinshasa. However, cases have been detected or transmission is ongoing at three sites, underscoring the need to watch the outbreak’s evolution closely.

Motorcycles, canoes, and satellite phones have been supplied to facilitate outbreak investigation and contact tracing. A dedicated helicopter will be made available soon.

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