Tuesday, November 26, 2024

Referral: MedCram On Avian Flu Mutations That Favor Human Transmission


#18,445

As a blogger without a degree, I rely heavily on the skills and knowledge of others. One of the my favorite sources of reliable medical information is MedCram, which synthesizes important medical information (primarily for clinicians and medical students) into remarkably clear online lectures.

I've been a fan (and a subscriber) for years, and use it often just to bone up on medical topics I'm interested in. While they have a paid tier, they also have an extensive YouTube Channel with more than 1.5 million subscribers and over 550 of these presentations.

Two weeks ago we learned that the critically ill teenager in British Columbia had been infected with the D1.1 genotype, which is similar to the genotype that infected > 12 poultry workers in Washington State.  

A week ago, however, we learned that initial sequencing had revealed ambiguous mutations at several key sites (Q226 and E190) in the HA gene, although their significance - and when they occurred - wasn't clear.

Yesterday Professor Roger Seheult, MD released a relatively short (12 min) review of what we know about the sequences from the B.C. case, titled: H5N1 Mutations Detected in Canadian Case Favor Human Transmission

Highly recommended.



We've not had an update from the B.C. Provincial Health officer Dr. Bonnie Henry on the condition of this teenager since Nov 12th, but there is a press briefing scheduled for this afternoon (2pm EST, 11am PST), where hopefully we'll learn more.