Thursday, May 05, 2016

Saudi MOH Announces 1 Asymptomatic MERS Case In Riyadh

# 11,344

Although sporadic asymptomatic MERS cases have been detected via contact tracing and prospective testing during outbreaks, we really don't have a good handle on their incidence in the larger community.

Like most viral infections, MERS-CoV can produce a wide range of symptomology, and many mild cases likely go undiagnosed.

In April we saw two asymptomatic cases announced by the Saudi MOH, while in March they reported three.   Today the MOH reports a new asymptomatic case - a household contact of a symptomatic case - in Riyadh.

For the vast majority of community acquired cases, the source of infection remains a mystery.  Asymptomatic carriage and transmission offers one plausible, if not proven, explanation (see Study: Possible Transmission From Asymptomatic MERS-CoV Case).

Last November's EID Journal: Risk Factors For Primary MERS-CoV Infection, Saudi Arabia found that camel exposure was a significant factor for infection, but that many community cases had no obvious exposure risk.  They wrote:

Other potential explanations of MERS-CoV illness in primary case-patients who did not have direct contact with dromedaries include unrecognized community exposure to patients with mild or subclinical MERS-CoV infection or exposure to other sources of primary MERS-CoV infection not ascertained in our study.

The World Health Organization interim guidance on the Management of asymptomatic persons who are RTPCR positive for Middle East respiratory syndrome coronavirus (MERS-CoV) Interim Guidance, calls for asymptomatic PCR-positive MERS cases to be isolated, and for their contacts be monitored as well.
But up until last fall, and contrary to WHO advice, the Saudi MOH didn't treat PCR positive MERS-CoV cases as `real cases’ unless they were symptomatic.

Now that the Saudis are taking asymptomatic cases more seriously, we have a better chance of discovering what role they may play.  For more on the possibility of there being some limited `stealth’ transmission of the virus in the community see The Community Transmission Mystery.