Monday, October 31, 2016

COCA Call Tomorrow: Zika in the ED: How Emergency Care Staff can Take Action










#11,862


With the likelihood that the Zika virus will remain a threat in the United States for years to come - and expectation the virus will eventually expand its geographic range beyond South Florida - it is important that Emergency Room staff know how to identify, treat, and report cases.

Tomorrow the CDC will hold a COCA call on precisely these topics.

Although primarily of interest to clinicians, the CDC holds frequent COCA (Clinician Outreach Communication Activity) calls which are designed to ensure that practitioners have up-to-date information for their practices.


Recorded materials from earlier COCA calls may be accessed at this link.  For those unable to attend this live presentation, it ought to be archived on the website within a few days.


Zika in the ED: How Emergency Care Staff can Take Action

Date: Tuesday, November 1, 2016

Time: 2:00-3:00 pm (Eastern Time)

Participate by Phone:
888-982-4696 (U.S. Callers)
415-228-4940 (International Callers)

Passcode: 1511429

Participate by Webinar: https://www.mymeetings.com/nc/join.php?i=PW1527344&p=1511429&t=c
Presenters

Monica Escalante Kolbuk, MSN, RN, CEN
Senior Associate, Institute for Quality, Safety and Injury Prevention
Emergency Nurses Association

Jon Mark Hirshon, MD, PhD, MPH
Professor, Department of Emergency Medicine and Department of Epidemiology and Public Health
University of Maryland School of Medicine
American College of Emergency Physicians  


Overview

Zika is a mosquito-borne disease currently spreading throughout multiple countries, three US territories, and in two small areas of Miami, FL, in the continental United States. People with Zika may seek care from various healthcare settings, including emergency departments. During this COCA Call, emergency providers will learn critical information about Zika, such as how to identify people at risk for infection either through recent travel or through sex with someone infected with Zika, examine the importance of screening protocols, and understand likely symptoms, such as fever, rash, and conjunctivitis. Additionally, emergency providers will learn key nursing assessment, clinical interventions, and the general process for reporting Zika cases.


Objectives

  • Outline the importance of screening protocols for Zika.
  • Review nursing assessment and clinical interventions as it relates to Zika.
  • Describe the process for reporting Zika cases.
  • Discuss patient education and discharge teaching for any people who may be at risk for, exposed to, or diagnosed with Zika.

Indonesia Battling More Avian Flu Outbreaks












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While no stranger to avian flu, Indonesia's MOH hasn't reported a human infection since early 2015.  In recent weeks, however, we have started to see more media reports of outbreaks in poultry.

Not quite three weeks ago, I blogged on  Indonesian Media: An Unusual Report Of H5N1 in Pigs on the islands of Bangka Belitung province while Crof picked up a report that H5N1 kills dozens of ducks in North Sulawesi.

We've not seen any official statements on these outbreaks, but the Indonesian government stopped filing routine reports to the OIE 10 years ago when H5N1 was declared endemic in Indonesia.

All of which means we are pretty much reduced to following media reports on outbreaks in poultry and wild birds. 

From the Times Indonesia we get a report out of Banjarmasin, suggesting the H5N1 virus has `mutated'.  While using the `M' word is always good for headlines, in truth, these avian viruses are always evolving.


Department of Animal Husbandry Banjarmasin Fearing Bird Flu Virus Mutated
Monday, October 31, 2016 15:40


BANJARMASINPOST.CO.ID, Banjarmasin - Until now, the Department of Agriculture and Fisheries of Banjarmasin not get the lab results on bird flu in Simpang The floating.

As is known, since two weeks ago is no bird flu findings were made seratun more chickens died suddenly. Chicken deaths of bird flu was confirmed through rapid test or rapid tests.

Actually, said Head Ranch Distankan Banjarmasin , Anwar Ziady, laboratory results with rapid testing is no different.

Only, of laboratory tests it can be seen whether the virus has mutated or not. "Is also a new type or not. So, it can be anticipated," he said.

So if ever the vaccination of poultry in Banjarmasin? According to Anwar, Banjarmasin is a zone of poultry quick trip.

That is, the birds in Banjarmasin not dwell long as farm centers or the like. "Sometimes, a week is where the migration of chicken. So it's hard," he said. (*)

Exactly why a `mutated' virus is suspected here isn't quite clear, and the mangled syntax via machine translation doesn't help much.  But it isn't without precedent. 

In the spring of 2010, after reports of poultry vaccine failures in Vietnam, we learned of the emergence of a new clade (classified as clade 2.3.2.1) of H5N1, which led to this 2011 statement FAO Warns On Bird Flu.

In 2012, this clade arrived in Indonesia (see EID Journal: H5N1 Clade 2.3.2.1 In Indonesia), sparking a large number of poultry outbreaks even in vaccinated birds. 


Meanwhile, in Lamongan, 200 miles south across the Java Sea, we get this report (again from The Times Indonesia).

There are two findings Poultry Bird Flu in Lamongan

Monday, October 31, 2016 - 12:27

TIMESINDONESIA, LAMONGAN - Department of Animal Husbandry and Animal Health (Disnak and Keswan) Lamongan, East Java confirmed the sudden death of hundreds of ducks in the Village / District Kembangbahu, due to the bird flu virus or Avian Influenza (AI).

"The test results quickly, the result was positive for bird flu in Kembangbahu," said Head of Animal Health DisnaKeswan Praise Hermawan, Monday (31/10/2016).

However, to ensure the gradual death of 700 ducks belonging to Fahmi Sabil Ansori, whether bird flu or not, Puji explain duck carcasses were sent to BB-vet (Center for Veterinary) Wates, Yogyakarta to do in-depth testing and diagnostics related poultry diseases.

"The carcasses tested PCR (polymer chain reaction), so it was taken to the vet BB-Wates, Yogyakarta," he said.

In fact, continued praise, not only of bird flu occurred in the village Kembangbahu alone. "Yesterday almost simultaneously in the poultry market. Its not know comes from where, as many traders poultry," he said.

We are hampered in both of these reports by the lack of laboratory testing, and the reliance upon in-the-field rapid tests.  Hopefully we'll get a more definitive report on whether any significant changes in the virus have occurred.

Sunday, October 30, 2016

USGS Statement On M6.6 Earthquake In Italy














#11,860

The USGS has released the following statement on the latest in a string of strong-to-severe earthquakes to strike central Italy (see M6.6 Earthquake Hits Norcia, Italy).


A magnitude 6.6 earthquake struck Italy on October 30, 2016 at 06:40:19 UTC (7:40 am local time). This is reportedly the largest earthquake in Italy since the magnitude 6.9 Irpinia earthquake struck southern Italy in 1980. 
This is a complex sequence of related earthquakes occurring on more than one fault segments in central Italy. We can expect aftershocks to continue for weeks and possibly months. We cannot rule out the possibility of similar sized or larger events, though the probability of a larger event is low. 

The largest earthquake in a sequence is generally referred to as the mainshock but each large earthquake will have associated aftershocks. Further research into this ongoing sequence will more clearly determine how each event relates to other earthquakes, and how the sequence as a whole developed in space and time.
Visit the USGS event page for more information. For estimates of casualties and damage, visit the USGS Prompt Assessment of Global Earthquakes for Response (PAGER) website. If you felt either earthquake, report your experience on the USGS Did You Feel It? website for this event.

The USGS operates a 24/7 National Earthquake Information Center in Colorado that can be reached for more information at (303) 273-8500.

Learn more about the USGS Earthquake Hazards Program.



Saudi MOH Reports 1 Primary MERS Case
















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After a two day lull the Saudi MOH reports a new Primary MERS case in Buraidah, a 41 y.o. Saudi male who is already listed in critical condition.   No likely source of infection is cited.


`Primary cases’ are those that occur in the community when there is no known exposure to a healthcare facility or to a known human case.  Some are linked to camel exposure, but most are not.

Over the past 4 years, roughly 48% of Saudi cases are listed as either `primary’ or as from an undetermined origin.

M6.6 Earthquake Hits Norcia, Italy














#11,858


On the heels of last Wednesday's damaging M6.1 and M5.5 quakes (and ongoing aftershocks) which struck in and around Norcia, Italy another - much larger M6.6 quake - has struck overnight.

Damage reports are still coming in, but it is likely to be heavy given the number of previously damaged structures.

While the difference between a 6.1 and a 6.6 quake may appear small on the scale, in actuality, the 6.6 quake is more than 5 times stronger than the 6.1 quake.  

This calculation from the USGS `How Much Bigger' Calculator.

Aftershocks continue to rock the region, and that activity could continue for days or weeks.  This same region was rocked by a M.62 quake in late August.

Much of central and (particularly) southern Europe is seismically active.  Below you’ll find the 2013 SHARE (Seismic Hazard Harmonization in Europe) seismic hazard map.




In 2011, in A Look At Europe’s Seismic Risks, we took a look at some of the most devastating earthquakes to strike Europe over the past 700 years, including the quake that leveled the Swiss town of Basel in 1356 and the horrific earthquake and tsunami that struck Portugal in 1755 on November 1st (All Saint’s Day).

Also in 2011 (see UNDP: Supercities At Seismic Risk) we saw a report that stated that half of the world’s supercities (urban areas with 2 million – 15 million inhabitants) are at high risk for seismic activity.

In January of 2012 (see UN Agency Warns On Global Seismic Risks), the United Nations International Strategy For Disaster Reduction (UNIDSR.Org) issued a cautionary warning about ignoring seismic threats.


Last month, during National Preparedness Month, we looked at the seismic risks for the United States in #NatlPrep: Half Of All Americans Need An Earthquake Plan.

 
For more on earthquake preparedness, both here in the United States, and around the world, you may wish to revisit:



Japan's Earthquake Preparedness Messaging - Tokyo's X Day 
USGS: Induced Earthquakes Raise Chances of Damaging Shaking in 2016 
California Quakes : Concrete Concerns
 
Estimating The Economic Impact Of A San Andreas Quake
 
USGS/OGS Joint Statement On Increased Earthquake Threat To Oklahoma

Saturday, October 29, 2016

India: Report of the Monitoring Committee on Avian Influenza













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This morning we have a report from yesterday's meeting of India's  Monitoring Committee on Avian Influenza, with additional details on the testing results for the H5N8 virus - particularly from the National Zoological Park in New Delhi. 
According to recent press reports, India's testing laboratories are backlogged with with thousands of samples yet to process, prompting yesterday's media report Bird flu: Centre asks NIHSAD to expedite testing of samples.

But in today's report we get a smattering of test results, including positive tests on several species and for pond water and mud around Pelican Pond, a popular stopover for migratory birds located within the National Zoological Park. 

First the report, then I'll return with a bit more.

Press Information Bureau
Government of India
Ministry of Environment and Forests
28-October-2016 20:38 IST
Report of the Monitoring Committee on Avian Influenza

The Monitoring Committee constituted by the Ministry of Environment, Forest and Climate Change for overseeing the outbreak of avian influenza reviewed the control and containment of the avian influenza situation today.

Mortality Status within 24 hours:

NATIONAL ZOOLOGICAL PARK, NEW DELHI -  Nil

DEER PARK, HAUZ KHAS, NEW DELHI          - Nil

GWALIOR ZOO                                              -  Nil



Action taken:

The control and containment measures of avian influenza in the affected zoos are being continued, which include:

1.      Surveillance continues and the zoo is being screened regularly for any dead bird.

2.      Bio-security measures being strictly enforced.

3.      Zoo remained closed for the safety of visitors and control of the disease.

4.      A medical doctor visited and examined exposed employees of the zoo and medication was provided.

5.      Report from ICAR National Institute of High Security Animal Diseases indicating updated interim results of samples sent on 22.10.2016 from National Zoological Park is enclosed. The results are as under:
6.      Review meeting was held under the Chairmanship of Animal Husbandry Commissioner on 27.10.2016 wherein the report was discussed.

7.      It was decided to put on hold the culling operations for the time being in the infected zone.

8.      Anti-viral solution is being sprayed on the affected mud near Pelican Island to prevent further infection.

9.      The water from Pelican Pond has also been tested positive for H5N8. The issue was discussed in the meeting and it was decided that treatment of water body by chemical such as bleaching powder, or lime, will not be feasible as it will adversely affect the aquatic life of the water body.
***

HK

The lack of reported bird deaths in the past 24 hours at the three zoos listed is a good sign, but the detection of the virus in the zoo's environment suggests that additional birds could still be infected.

Avian influenza is gastrointestinal infection in birds, and they shed the virus through their feces - which can easily contaminate fresh water sources.
Previous tests conducted on other HPAI and LPAI avian viruses (including H5N1) have shown prolonged persistence in the environment (see H5N1: Hiding In Plain Sight and EID Journal: Persistence Of H5N1 In Soil), remaining viable for days or even weeks depending upon conditions. 

Another finding of note is the positive test result on a Crow.

While waterfowl (ducks & geese) and gallinaceous birds (turkeys, grouse, chickens & quail) are most often associated with carriage of HPAI H5 viruses, terrestrial birds such as crows, starlings, pigeons, and sparrows are also known to carry, and shed, theses  viruses as well (see 2007’s EID Journal  Role of Terrestrial Wild Birds in Ecology of Influenza A Virus (H5N1). 

As far back as 2008, we saw reports out of India of crows dying from the H5N1 virus. In 2012, and again in 2014 India saw numerous wild bird die offs that were blamed on the avian flu virus (see Media Report: H5N1 Killing Crows In Jharkhand).

Although the incidence of terrestrial bird carriage of HPAI viruses is poorly understood and its significance remains hotly debated, recent studies and surveillance suggests their role may be greater than previously believed.

With the emergence of new avian flu viruses around the globe nearly every year, the research into their interactions with thousands of non-aquatic bird species has only just begun.

Although there are media reports of other Indian States awaiting test results, as of this writing no new outbreaks have been confirmed.

Friday, October 28, 2016

Netherlands: `Mild' H5 Avian Flu Reported In Deurne















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From the Netherlands  this morning we have an announcement of an outbreak of reportedly `Mild' H5 bird flu on a poultry farm in Deurne (see map above).

At this point, we don't have a complete subtype identified, and it will probably take a day or so before we get a full description of the virus.  The assumption at this time this is an LPAI H5 virus.


There are two broad categories of avian influenza; LPAI (Low Pathogenic Avian Influenza) and HPAI (Highly Pathogenic Avian Influenza).
  • LPAI viruses are quite common in wild birds, cause little illness, and only rarely death.  They are not considered to be a serious health to public health. The concern is (particularly with H5 & H7 strains) that LPAI viruses have the potential to mutate into HPAI strains.
  • HPAI viruses are more dangerous, can produce high morbidity and mortality in wild birds and poultry, and can sometimes infect humans with serious result. The type of bird flu scientists have been watching closely for the past decade has been HPAI H5N1 (and to a lesser extent HPAI H7s & H9s).

Before the middle of the last decade, there was no uniform requirement to report or track LPAI infections. That changed in 2006 when the OIE made reporting of LPAI H5 & H7 viruses mandatory.

This from the Netherlands Ministry of Economic Affairs.



In Deurne (Noord-Brabant) is a poultry farm with 11,000 turkeys bird flu (avian influenza, AI) established. The company also 3,500 pheasants and 2,000 meat ducks housed. These animals are housed outside. It is probably a mild H5 variant.
Because a low pathogenic (mild) H5 variant can mutate to a highly pathogenic (highly contagious and fatal for poultry) variant, the company has both a low- be culled as a highly pathogenic variant. This is based on European rules. The culling is carried out by the Dutch Food and Goods Authority (NVWA).

measures

From October 28, 2016 at 11:30 am there is a zone of over one kilometer around the holding in Deurne a ban on transporting poultry, eggs, poultry manure and used bedding. Within the area there are three other poultry farms. These companies are sampled and tested for avian influenza.

FAO Notification Of H5N8 In Hungary


 #11,855

Overnight the FAO confirmed the report from yesterday (see Hungary: H5N8 Found In Dead Swan), which is Europe's first report of HPAI H5 this fall.  
 

http://empres-i.fao.org/empres-i/2/obd?idOutbreak=218267&rss=t

After making a number of tentative appearances across Europe  during the fall/winter of 2014-2015 (see map below), the H5N8 virus was basically a no-show last winter.



While it is too soon to know how much of an impact we'll see this year, recent reports of H5N8 in Russia, India, and now Hungary are enough to warrant extra attention - and beefed up biosecurity measures - across the EU.


India: Punjab State Now Reporting H5N8





















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As the testing laboratories in Bhopal work their way through the backlog of thousands of samples, we are are likely to learn of other regions of India where avian H5N8 has already arrived.

Today it is Punjab state, in the North of India and adjacent to neighboring Pakistan, where samples collected last week have now been confirmed as positive for the H5N8 virus. 

This overnight from the Indian Express.


Bird flu enters Punjab for the first time

After the deaths were reported to the state’s animal husbandry department, it first sent the samples to the Regional Disease Diagnostic Laboratory (RDDL) in Jalandhar for testing.


Written by Adil Akhzer | Chandigarh | Published:October 28, 2016 9:04 am

In the first case of bird flu in Punjab, samples from two ducks found dead in an industrial unit’s reservoir at Rajpura in Patiala district last week have tested positive for H5N8 avian influenza (commonly known as bird flu). The samples were sent to National Institute of High Security Animal Diseases in Bhopal, which confirmed that the deaths were due to bird flu.


(Continue . . . )

The Central Asian-Indian Flyway that funnels birds from their Siberian and Arctic summer breeding grounds south and west to India, also serves as a conduit to Central Asia, and parts of the Middle East (see green shaded area in map below).




While these flyways are predominately north-south corridors, their overlapping (particularly over their northern breeding grounds) allows for a lateral (east-west) movement of avian viruses as well

All of which means that we shouldn't be too surprised if we start seeing H5N8 reports from countries and regions both east, and west of the Indian Subcontinent over the next couple of months.
 

Thursday, October 27, 2016

MMWR: Investigation Into H3N2v Outbreak In Ohio & Michigan - Summer 2016

















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Last August, over a period of several weeks, we followed the reports of 18 people - all fair attendees - who were diagnosed with a swine variant influenza virus called H3N2v in two states; Michigan and Ohio.  Among those blogs:
CDC FluView: 7 More H3N2v Cases (4 Michigan, 3 Ohio) In Week 33
Michigan H3N2v Cases Rise To 8
Ohio: More Reports Of H3N2 In Exhibition Swine
CDC: Interim Guidance for Clinicians on Human Infections with Variant Influenza Viruses

This was the biggest outbreak of swine variant infections we'd seen since 2012, when more than 300 cases were reported across 10 states.  The CDC describes Swine Variant viruses in their Key Facts FAQ.
What is a variant influenza virus?
When an influenza virus that normally circulates in swine (but not people) is detected in a person, it is called a “variant influenza virus.” For example, if a swine origin influenza A H3N2 virus is detected in a person, that virus will be called an “H3N2 variant” virus or “H3N2v” virus.

These swine variant viruses are a concern because one could someday become well enough adapted to human physiology to transmit efficiently in the community - which is essentially what happened in 2009 when the pandemic H1N1 virus emerged.

Today the MMWR carries our first detailed look at the investigation into this summer's outbreak, along with a genetic analysis of the viruses isolated. 

The `headline' in this report is that 16 of the 18 cases analyzed belonged to a new genotype not previously detected in humans. The reports explains:
Whereas these viruses contained seven gene segments similar to segments detected in previously reported variant virus outbreaks, one gene segment coding for an influenza A(H3) hemagglutinin (HA) gene was determined to be similar to HA genes found in human seasonal influenza A(H3N2) viruses from 2010 and 2011.
This HA gene was likely introduced from humans into swine in 2010 or 2011, and has since circulated and evolved in swine to be genetically and antigenically different from both previous and currently circulating human seasonal influenza A(H3N2) viruses (3).

The full report is very much worth reading, and it highlights the need to prevent transmission of influenza viruses both to, and from, pigs.


Due to its length I'll only post some excerpts. Follow the link to read the report in its entirety.   When you return, I'll have a bit more:


Outbreak of Influenza A(H3N2) Variant Virus Infections Among Persons Attending Agricultural Fairs Housing Infected Swine — Michigan and Ohio, July–August 2016

Weekly / October 28, 2016 / 65(42);1157–1160


Rebekah S. Schicker, MSN, MPH1,2; John Rossow2,3; Seth Eckel, MPH4; Nicolas Fisher5; Sally Bidol, MPH4; Lilith Tatham, DVM5; Janice Matthews-Greer, PhD4; Kevin Sohner, PhD5; Andrew S. Bowman, DVM, PhD6; James Avrill, DVM, PhD7; Tony Forshey, DVM8; Lenee Blanton, MPH2; C. Todd Davis, PhD2; John Schiltz, DVM9; Susan Skorupski, DVM10; LaShondra Berman, PhD2; Yunho Jang, PhD2; Joseph S. Bresee, MD2; Stephen Lindstrom, PhD2; Susan C. Trock, DVM2; David Wentworth, PhD2; Alicia M. Fry, MD2; Sietske de Fijter, MS5; Kimberly Signs, DVM4; Mary DiOrio, MD5; Sonja J. Olsen, PhD2; Matthew Biggerstaff, MPH2 

Summary


On August 3, 2016, the Ohio Department of Health Laboratory reported to CDC that a respiratory specimen collected on July 28 from a male aged 13 years who attended an agricultural fair in Ohio during July 22–29, 2016, and subsequently developed a respiratory illness, tested positive by real-time reverse transcription–polymerase chain reaction (rRT-PCR) for influenza A(H3N2) variant* (H3N2v). The respiratory specimen was collected as part of routine influenza surveillance activities. The next day, CDC was notified of a child aged 9 years who was a swine exhibitor at an agricultural fair in Michigan who became ill on July 29, 2016, and tested positive for H3N2v virus at the Michigan Department of Health and Human Services Laboratory. Investigations by Michigan and Ohio health authorities identified 18 human infections linked to swine exhibits at agricultural fairs.
To minimize transmission of influenza viruses from infected swine to visitors, agricultural fair organizers should consider prevention measures such as shortening the time swine are on the fairgrounds, isolating ill swine, maintaining a veterinarian on call, providing handwashing stations, and prohibiting food and beverages in animal barns. Persons at high risk for influenza-associated complications should be discouraged from entering swine barns.
      (Continue . . . )

What is already known about this topic?

Sporadic human infections and outbreaks with influenza viruses that normally circulate in swine have occurred in the past. The largest known outbreak of H3N2v virus infections occurred in 2012.


What is added by this report?


In August 2016, 18 laboratory-confirmed infections with H3N2v virus were reported among persons who had attended agricultural fairs in Michigan and Ohio. Sixteen of the 18 cases occurred in persons who were infected with a reassortant H3N2v virus that contained a hemagglutinin (HA) gene previously not detected in variant viruses.


The HA gene was likely introduced from humans into swine in 2010 or 2011, and viruses with this gene have circulated and evolved in swine to be genetically and antigenically different from both previous and currently circulating human seasonal influenza A(H3N2) viruses.

What are the implications for public health practice?

To minimize transmission of influenza viruses from swine to humans and from humans to swine, agricultural fair organizers should consider measures such as shortening the time swine are on the fairgrounds to ≤72 hours, immediately isolating ill swine, maintaining a veterinarian on call for the duration of the swine exhibition, providing prominent handwashing stations, and prohibiting food and beverages in animal barns. Persons at high risk for influenza-associated complications should be discouraged from entering swine barns.

     
Of the three swine variant strains reported in the United States (H1N1v, H1N2v, & H3N2v), H3N2v has been by far the most common, making up 95% of all reported cases. 
Since the influenza subtypes that commonly circulate in swine are also the same that have caused all of the human pandemics going back 130 years (see Are Influenza Pandemic Viruses Members Of An Exclusive Club?), they are generally regarded as having less far to `jump’ to humans than do many avian viruses.
Which is why we watch reports like today's with particular interest. For more on swine variant viruses, both in the United States and around the world, you may wish to revisit:

PNAS: The Pandemic Potential Of Eurasian Avian-like H1N1 (EAH1N1) Swine Influenza
Front. Microbiol.: A Novel H1N2 Reassorted Influenza Virus In Chinese Pigs
Sci Rpts: Transmission & Pathogenicity Of Novel Swine Flu Reassortant Viruses
Eurosurveillance: Seroprevalence Of Cross-Reactive Antibodies To Swine H3N2v – Germany
  

India: MOH Statement On Low Risk From & Protective Measures Against H5N8













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Since H5N8 arrived last week in New Delhi, much of the public  health messaging coming  from India's state governments have been along the reassuring lines of H5N8 Virus Will Not Spread to Humans, Says Kerala Government and Bird Flu Scare: Virus Less Infective, No Threat to Humans, Assures Delhi Govt. 


While the risks are undoubtedly low, our own CDC doesn't consider them zero, and last summer they issued a CDC HAN:HPAI H5 Exposure, Human Health Investigations & Response, urging doctors to be alert to possible infections and advising:
People exposed to HPAI H5-infected birds (including people wearing PPE) should be monitored for signs and symptoms consistent with influenza beginning after their first exposure and for 10 days after their last exposure. Influenza antiviral prophylaxis may be considered to prevent infection (see below).

Today, India's Ministry of Health & Family Welfare - out of an abundance of caution - has released similar guidance.


Ministry of Health and Family Welfare
27-October-2016 18:40 IST
Low Public Health Risk from Avian Influenza A H5N8

A number of wild birds died in National Zoological Park and Deer Park, both situated in Delhi and Zoological Park, Gwalior in the preceding two weeks. Domesticated bird deaths (ducks) were reported this week from Alappuzha District of Kerala. In all these instances, samples tested at the National Institute of High Security Animal Diseases, Bhopal were found positive for Avian Influenza A H5N8.

On the public health risk of Avian Influenza A H5N8, World Health Organization has informed that “based on current knowledge, the risk of zoonotic transmission is considered low for H5N8”.

As a matter of abundant caution, Ministry of Health and Family Welfare has advised the State Health Departments to use personal protective equipment by those handling dead/sick birds, keep persons exposed to the dead/sick birds under surveillance and provide them chemoprophylaxis (Oseltamivir 75 mg once daily for 10 days).

A Joint Coordination Committee in the Department of Animal Husbandry, Dairying and Fisheries, with representation from Ministry of Health and Family Welfare is monitoring the situation.



Hungary: H5N8 Found In Dead Swan












#11,851


With the return of fall weather we've been watching for signs that H5N8 might once again be on the move in migratory birds after reports earlier this summer of its detection in Russia. 

Last week we saw H5N8 show up in multiple locations in India, yesterday we saw media reports of suspected bird flu in Kazakhstan, and today we have a media report and an announcement from Hungary's NÉBIH (Department of Animal Health and Animal Welfare).

First, this from Delmagyar.hu.

Bird flu found in swan Csongrad County
   
2016.10.27. 13:36

A dead swan Csongrad County revealed the presence of avian influenza to NÉBIH. They call attention to the keepers of the importance of prevention.

The H5N8 strain of bird flu in the past two years has caused several epidemics in poultry populations worldwide, serious direct and indirect damage causing. Currently, many countries are struggling with avian influenza.

Epidemiological studies suggest that migratory birds also plays a role in spreading the disease. Most at risk are the waterfowl flocks, which were held in whole or in part catwalk pasture. During the bird migration period should therefore be protected from poultry to wild birds from contact increased. It is essential that farmers strictly adhere to the overall disease control rules and notify their veterinarian or the veterinary authority if any symptoms seen their stock - warns NÉBIH


While lacking in specifics, the following (translated) announcement is found (dated today) on the  NÉBIH .gov site.

Take precautionary measures against bird flu

2016 October 27

It revealed the presence of avian influenza virus in dead swan NÉBIH a Csongárd County. The detected serotypes (H5N8) has never occurred in the context of human disease. However, the poultry flocks is a serious threat, and therefore calls on the authorities of the breeders' attention to the importance of prevention.

The H5N8 strain of bird flu in the past two years has caused several epidemics in poultry populations worldwide, serious direct and indirect damage causing. Currently, many countries are struggling with avian influenza.

Epidemiological studies suggest that migratory birds also plays a role in spreading the disease. Most at risk are the waterfowl flocks, which were held in whole or in part catwalk pasture. During the bird migration period should therefore be protected from poultry to wild birds from contact increased. Preventive measures should address a protected feeding, watering and feed and manure storage safe.

The symptoms of avian influenza may be a separate species, which depend on the ability of pathogenic viruses, the bird species, age, housing conditions. Initial symptoms include loss of appetite, reduction in water intake and death of a few individuals. Later on, or otherwise abrupt or without previous symptoms may also high mortality. The disease can be a sign of decline in egg production or weight gain as well.

It is essential that farmers strictly adhere to the overall disease control rules and notify their veterinarian or the veterinary authority if any symptoms seen their stock.

The possible consequences of the disease and more information on the NÉBIH website .

Director of Animal Health and Animal Welfare


Given the migratory bird flyways (see below), and the generally south and west fall migration, countries across Europe, the Middle East and Africa need to be on the alert for the potential arrival of HPAI H5N8 this fall and winter.

 

CDC: Healthcare Exposure to Zika and Infection Control









#11,850


A little over a month ago, in MMWR: Investigation Into the `Unique' Utah Zika Case, we looked at the CDC's investigation into the infection of a family member caring for a relative with Zika, without any of the known risk exposures (mosquito vector, sexual contact, blood transfusion).

The elderly family member - who had serious comorbidities - died of organ failure on June 25th, while the caregiver developed symptoms on July 1st.

Of particular note, the MMWR reported that `The index patient’s blood specimen obtained 2 days before his death had a level of viremia approximately 100,000 times higher than the average level reported in persons infected with Zika virus (2).'   

Despite a detailed investigation, exactly how this caregiver contracted the Zika virus remains unclear, causing the CDC to warn: ` . . .  family contacts should be aware that blood and body fluids of severely ill patients might be infectious.'

Hyperbolic tabloid headlines aside, the evidence suggests this to be a very rare occurrence with Zika.

Nevertheless, this scenario is assumed a possibility by all healthcare workers who adhere to the `Standard Precautions' principle, but is less often considered by family members or lay people.



The CDC defines `Standard Precautions' as:
Standard Precautions represent the minimum infection prevention measures that apply to all patient care, regardless of suspected or confirmed infection status of the patient, in any setting where healthcare is delivered. These evidence-based practices are designed to both protect healthcare personnel and prevent the spread of infections among patients.
Standard Precautions replaces earlier guidance relating to Universal Precautions and Body Substance Isolation. Standard Precautions include:  1) hand hygiene, 2) use of personal protective equipment (e.g., gloves, gowns, facemasks), depending on the anticipated exposure, 3) respiratory hygiene and cough etiquette, 4) safe injection practices, and 5) safe handling of potentially contaminated equipment or surfaces in the patient environment.
 
The CDC has published an updated Healthcare Exposure To Zika and Infection Control document, which addresses both HCW, and lay caregivers and visitors, who may be exposed to a Zika patient.

The document has 8 main sections:

The gist being:

Preventing Exposure in Healthcare Settings
Standard Precautions should be used to protect healthcare personnel from all infectious disease transmission, including Zika virus. Standard Precautions are based on the fact that all blood, body fluids, secretions, excretions, non-intact skin, and mucous membranes might contain transmissible infectious agents. Body fluids, including blood, vaginal secretions, and semen, have been implicated in transmission of Zika virus. Current information about Zika virus transmission and risks can be found on CDC’s Zika Transmission webpage.

HCWs will want to read the full document for specific scenarios, room disinfection procedures, and testing recommendations.  For the general public, the CDC has the following advice:

Advising Caretakers and Visitors of People with Zika

As with any other infectious illness, family members and other caregivers should take the following precautions

  • Do not touch blood or body fluids and surfaces contaminated with these fluids with exposed skin.
  • Wash hands with soap and water immediately after providing care to the patient. If hands are not visibly dirty, an alcohol-based hand rub can be used instead of soap and water.
  • Immediately remove and wash clothes if they get blood or body fluids on them. Use laundry detergent and the water temperature specified in the garment care instructions to wash clothes soiled with blood or body fluids. Using bleach is not necessary.
  • Immediately clean and disinfect surfaces that have blood or other body fluids on them, minimizing direct contact, using household detergent/disinfectant according to manufacturer’s instructions. The sick person’s immediate environment should be cleaned daily using household cleaners according to manufacturer’s instructions.
Pregnant women should follow the same precautions as other family members caring for a person with Zika, including avoiding activities that would expose them to blood or other potentially infectious body fluids.

When visiting a patient in a hospital setting, visitors should not engage in activities that could possibly expose them to blood or body fluids from a hospitalized patient. Helping a patient with sitting up in bed or walking should not expose someone to blood or body fluids; however, family members and caregivers should pay attention to hygiene, not touch blood or body fluids or surfaces soiled with them, and wash hands before and after touching the patient.

Common sense precautions that should apply whenever you are providing care to another person, regardless of whether they have a Zika infection, Influenza, or the common cold. 

And a pretty good reason to keep a modest supply of exam gloves, surgical masks, and hand sanitizer in your home (and auto) first aid kit (see #NatlPrep : One For The Home, And One More For The Road).


 

Wednesday, October 26, 2016

Saudi MOH Announces 1 MERS-CoV Case

  



 #11,849


The Saudi MOH website was offline for several hours, and so today's update was several hours late in being posted. Despite the wait,  it doesn't shed any light on yesterday's media report of 6 cases in an Al-Ahsa hospital.

Instead, we learn of a new secondary case; a household contact of a primary case from Arar we learned about on Sunday.

Today's case is a 65 y.o. male expat listed in stable condition. 

 

Kazakhstan: Media Report Of Suspected Avian Flu In Poultry










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With the arrival of cooler fall weather, avian flu activity in the Northern Hemisphere usually starts to rise.  So this time of year we tend to scour relatively obscure foreign media sources looking for signs of outbreaks.

Granted, media reports aren't always a reliable source. While these reports can occasionally provide us with a valuable head's up, as always, Caveat Lector.

Bearing that in mind, from Kyrgyzstan's National News Agency (KABAR) we get the following (translated) report of suspected HPAI H5 outbreaks in poultry in neighboring Kazakhstan.

Kyrgyzstan will check chicken products from Kazakhstan for avian influenza

Bishkek, October 25 / Mehriniso Sulaimanova -. Kabar / start checking chicken products from Kazakhstan for avian influenza in Kyrgyzstan. The agency "Kabar" said Head of the state veterinary supervision of the State Inspectorate for veterinary and fitosaniratarii Tolon Yrsaliev.

Note that today, it was reported in the local media that the north of Kazakhstan en masse are dying birds suspected of avian influenza (H5N1).

"We are working with poultry farmers in neighboring countries. And we have received information that in the north of Kazakhstan recorded outbreak of avian influenza. However, the official did not report it to the authorities of Kazakhstan did not confirm, "- quoted by the media the word domestic fanciers Ermek Mamyrkanova.
As explained in the State Inspectorate for veterinary and phytosanitary, Kyrgyzstan to Kazakhstan today sent an official letter in this regard.

"We still do not have official information. The fact that this happens, we have learned from the media. Also from the press, we learned that the Kazakhs were assured that it's not avian flu and salmonella. This is also a harmful disease, but it is not spreading rapidly, as avian influenza, "- said Tolon Yrsaliev.

He also said that today begins checking products that will be imported from the Karaganda region.

"We have a register of suppliers, through them, to begin work, the samples will be delivered to the laboratory for testing. If confirmed, the borders are completely closed to imports of these products from neighboring states. By the way, in case of outbreaks of some diseases, Kazakhstan should have warned the international representational office which deals with such matters, because it really is a terrible disease, "- said T. Yrsaliev.

Although H5N1 is mentioned as a probable cause, it is worth noting that Northern Kazakhstan lies only a few hundred miles to the west of Ubsu-Nur Lake, Russia where H5N8 was detected over the summer in wild and migratory birds (see FAO/EMPRES: H5N8 Clade 2.3.4.4 Detected Over Summer In Russia).

While there are two annual bird migrations (spring and fall), a recent report (see Sci Repts.: Southward Autumn Migration Of Waterfowl Facilitates Transmission Of HPAI H5N1) pegs the fall migration as the biggest risk for the spread of HPAI by migratory birds.

With the overlapping and generally south and west fall migratory pattern (see map below), all of Central Asia, Eastern Europe, The Middle East, and even parts of Africa must remain alert for HPAI.

Credit DEFRA


For more on all of this, you may wish to revisit:

Migratory Birds & The Spread Of Highly Pathogenic Avian Flu

COCA Call Tomorrow: 2016-2017 Flu Season - Recommendations for Children










#11,847




Tomorrow  the CDC will hold a COCA call for clinicians on what's new for the 2016-2017 flu season, particularly for children.

Although primarily of interest to clinicians, the CDC holds frequent COCA (Clinician Outreach Communication Activity) calls which are designed to ensure that practitioners have up-to-date information for their practices.

Recorded materials from earlier COCA calls may be accessed at this linkFor those unable to attend this live presentation, it ought to be archived on the website within a few days.


Date: Thursday, October 27, 2016

Time: 2:00-3:00 pm (Eastern Time)

Participate by Phone:
888-566-7688 (U.S. Callers)
1-517-308-9182 (International Callers)


Passcode: 1528968


Participate by Webinar: https://www.mymeetings.com/nc/join.php?i=PW1527852&p=1528968&t=c


Presenter(s)

Lisa Grohskopf, MD, MPH
Medical Officer
National Center for Immunization and Respiratory Diseases
Centers for Disease Control and Prevention



Henry H. Bernstein, DO, MHCM, FAAP
Professor of Pediatrics at Hofstra North Shore
LIJ School of Medicine



Overview


Influenza (flu) is more dangerous than the common cold for children. Each year, an average of 20,000 children under the age of 5 are hospitalized because of flu-related complications. Clinicians have a critical role in taking action to immunize children, children’s family members and caregivers, and themselves. Use of antiviral drugs early in children can lessen the impact of influenza infection, but immunization remains the most effective means of preventing the flu and complications from the flu.
For the 2016-2017 flu season, several new recommendations have been identified that particularly impact flu vaccination for children. During this COCA call, subject matter experts from the American Academy of Pediatrics (AAP) and the Centers for Disease Control and Prevention (CDC) will highlight this critical information and discuss strategies that primary care providers and medical subspecialists can use to improve flu prevention and control in children.


Objectives

At the conclusion of the session, the participant will be able to accomplish the following:
  • Describe strategies to prepare for the 2016-2017 influenza season.
  • Identify key recommendations in the AAP influenza policy statement.
  • Discuss vaccine effectiveness.
  • Clarify recommendations related to live attenuated influenza vaccine.
  • Explain the importance of antiviral medications in the control of influenza.
  • Discuss flu vaccine and egg allergic children.

India MOA: Centre Constitutes Committee for monitoring Bird Flu











 

#11,846


It has now been a full week since we first heard of the outbreak of avian flu at New Delhi's Zoological Park, which was subsequently identified as HPAI H5N8.  Since then, bird die offs in two other Indian States (Madya Pradesh & Kerala) have been identified as H5N8 as well.

This is the first incursion of H5N8 into India, which was almost certainly carried in by migratory birds, and so the risk of further spread is likely high.

According to media reports, test results from the central lab in Bhopal and the regional one in Jalandhar have been slow in coming (see Bird flu outbreak: Delhi urges central labs to hurry up with test results), and so it is always possible there are already other outbreaks that have not yet been verified. 

While the risk of transmission of this virus to humans is believed low, this virus is a close relative to two viruses (H5N1 & H5N6) that have infected humans in the past, and so on Monday we saw the Delhi Govt. Issues Health Advisory On H5N8.


In need of a coordinated response, today the Indian Ministry of Agriculture announced the formation of a committee to monitor H5N8, consisting of representatives from several governmental Ministries and Agencies.

Press Information Bureau
Government of India
Ministry of Agriculture
26-October-2016 15:42 IST


Centre Constitutes Committee for monitoring Bird Flu

The Centre has constituted a Committee headed by Joint Commissioner, Department of Animal Husbandry, Dairy and Fisheries (DADF) to maintain constant vigil on the situation arising out of avian influenza (H5N8). The Committee will have representatives from Ministry of Health, Ministry of Environment, Forests and Climate Change and Department of Agriculture Research and Extension (DARE) and representative of the Delhi Government. Besides, monitoring the situation, the Committee will assist the State Government in taking steps to contain the spread of Avian Influenza.

The Centre has also established a control room in DADF. The Control Room can be reached at these telephone numbers : 011-23384190 and 09448324121. Joint Commissioner, Dr. Munialappa has been named as the Nodal Officer and will be available for advice and help round the clock.

The National High Security lab for animal diseases - NIHSAD - the world body OIE recognised facility for disease diagnosis in South Asia and the Four Regional Laboratories, and the Central lab at IVRI have been instructed to give all assistance to the State Governments and get sample tested in an emergency response manner. In fact all 45 samples obtained from Delhi government at the Bhopal lab have been tested within the stipulated 72 hour time frame as per Bio-security level -4 requirements and 13 cases have tested positive for H5N8. Similarly test results have been given for other cases in Kerala, Punjab and MP. As per available reports from other states, the disease incidence is in control.

The Animal Husbandry, Dairy and Fisheries Department of the States have issued guidelines for maintaining cleanliness in the zoological parks housing wild birds, water bodies as well as meat / poultry market areas where meat is sold. Necessary precautions for human beings coming in the contact with poultry have also been reinforced although as per WHO observations, the transmission of H5N8 virus is very low. Also there will be no trade impact of the incidence as per global OIE criteria.

All bird sanctuaries and areas where there are lakes have been advised to keep a close watch on the situation and in case of any suspicious death of birds, the State Government and the Centre may be notified. No further test results are presently required by Delhi government to continue with its bio-security measures for implementing the National Action Plan for Control and Containment of the Avian Influenza, 2015 guidelines. Full support of the government of India health department, urban development department, environment department apart from animal husbandry department under the ministry of agriculture & farmers welfare is being provided and there is full communication with the Delhi government on the on-going steps to contain and control the disease incidence.

Daily meetings are being held at the Animal Husbandry Commissioner level in DADF to advise the State Governments in case of emergency.

It may recalled that on 17.10.2016 some birds had died in the Delhi Zoological Park and thereafter birds had died in six other areas. A sample was sent on 17.10.2016 to NIHSAD, and on the same day it was confirmed that the birds had died of H5NH8 virus. A close watch is being maintained and necessary advisories have been issued to all states to keep a vigil on areas frequented by birds both domestic and migratory. Secretary DADF, Shri Devendra Chaudhry is himself keeping close watch and is in constant touch with the chief secretaries of affected states including specially Delhi.