Friday, September 13, 2019

CDC Update On Acute Lung Injuries LInked To Vaping

Credit CDC


















#14,302

Nearly a month ago the CDC announced an investigation into unexplained acute pulmonary illnesses being reported in dozens of people using e-cigarettes (see CDC Clinical Action: Unexplained Vaping-Associated Pulmonary Illness).

Since then, we've been following this story as the number of suspected and probable cases around the country has continued to grow.

Some recent blogs include:
CDC MMWR Early Release: Acute Lung Injury LInked To Vaping
CDC : Outbreak Investigation & Telebriefing On Pulmonary Disease Linked To Vaping
CDC Clinical Action: Unexplained Vaping-Associated Pulmonary Illness 
Last Friday, the possible, probable, and confirmed case count stood at 450, but this week's update has dropped to 380 because possible cases (still under investigation) are no longer included.

The CDC elaborates on this change below:
CDC, states update number of cases of lung disease associated with e-cigarette use, or vaping
Media Statement

For Immediate Release: Thursday, September 12, 2019
Contact: Media Relations
(404) 639-3286

CDC today announced the updated number of confirmed and probable cases of lung disease associated with e-cigarette product use, or vaping. The new case count is the first national aggregate based on the new CDC case definition developed and shared with states in late August.

Cases

  • As of September 11, 2019, 380 confirmed and probable cases of lung disease associated with e-cigarette product use, or vaping, were reported by 36 states and the U.S. Virgin Islands.
  • The previous case count released by CDC was higher because it reported possible* cases that were still under investigation by states. The current number includes only confirmed** and probable*** cases reported by states to CDC after classification.
  • CDC is no longer reporting possible cases or cases under investigation and states have recently received the new CDC case definition to classify cases. The classification process requires medical record review and discussion with the treating healthcare providers. The current number is expected to increase as additional cases are classified.
CDC will continue to report confirmed and probable cases as one number because the two definitions are very similar and this is the most accurate way to understand the number of people affected.
*A possible case is one still under investigation at the state level.

**A confirmed case is someone who recently used an e-cigarette product or vaped, developed a breathing illness, and for whom testing did not show an infection. Other common causes of illness have been ruled out as the primary cause.

***A probable case is someone who recently used an e-cigarette product or vaped, developed a breathing illness, and for whom some tests have been performed to rule out infection. Other common causes of illness have been ruled out as the primary cause.
Deaths
Six total deaths have been confirmed in six states: California, Illinois, Indiana, Kansas, Minnesota, and Oregon.
The CDC's weekly update page provides more details:

Posted September 12, 2019 at 6:15pm ET


CDC, the U.S. Food and Drug Administration (FDA), state and local health departments, and other clinical and public health partners are investigating a multistate outbreak of lung disease associated with e-cigarette product (devices, liquids, refill pods, and/or cartridges) use.


Key Facts about E-Cigarette Use, or Vaping
  • Electronic cigarettes – or e-cigarettes — are also called vapes, e-hookahs, vape pens, and electronic nicotine delivery systems (ENDS).
  • Using an e-cigarette product is commonly called vaping.
  • E-cigarettes work by heating a liquid to produce an aerosol that users inhale into their lungs.
  • The liquid can contain: nicotine, tetrahydrocannabinol (THC) and cannabinoid (CBD) oils, and other substances and additives.
What we know
  • There are over 380* possible cases of lung illness reported from 36 states and 1 U.S. territory. Six deaths have been reported from 6 states.
  • All reported cases have a history of e-cigarette product use or vaping.
  • Most patients have reported a history of using e-cigarette products containing THC. Many patients have reported using THC and nicotine. Some have reported the use of e-cigarette products containing only nicotine.

What we don’t know
  • We do not yet know the specific cause of these illnesses. The investigation has not identified any specific e-cigarette or vaping product (devices, liquids, refill pods, and/or cartridges) or substance that is linked to all cases.

What CDC recommends
  • CDC has released interim recommendations for healthcare providers, health departments, and the public.
  • Until we know more, if you are concerned about these specific health risks, CDC recommends that you consider refraining from using e-cigarette or vaping products.
  • If you are an adult who used e-cigarettes containing nicotine to quit cigarette smoking, do not return to smoking cigarettes.
  • If you have recently used an e-cigarette or vaping product and you have symptoms like those reported in this outbreak see a healthcare provider.
  • Regardless of the ongoing investigation:
Latest Outbreak Information on Lung Disease Associated with Electronic Cigarettes
  • As of September 11, 2019 at 5pm, 380* cases of lung illness associated with the use of e-cigarette products have been reported to CDC from the following states and 1 U.S. territory: AR, CA, CO, CT, DE, FL, GA, HI, IA, ID, IL, IN, KS, KY, LA, MD, MI, MN, NC, ND, NE, NJ, NM, NV, NY, OH, OR, SC, SD, TN, TX, UT, VA, WA, WI, WV, and USVI. These numbers may change frequently.
  • Six deaths have been confirmed in California, Illinois, Indiana, Kansas, Minnesota, and Oregon.
  • CDC worked with states to create a case definition to classify confirmed and probable cases in a consistent way. State investigators determine if cases are confirmed or probable after examining the medical records of suspected cases and consulting with the clinical care team to exclude other possible causes of illness. Unlike nationally reportable conditions, these cases are requiring clinicians and public health professionals to interview patients to determine product use and individual behaviors.
  • CDC will report numbers of confirmed and probable cases once states have finalized their classification of cases.
  • States are in the process of classifying cases. We expect that states and clinicians may look back for older cases based on CDC’s case definition.
  • All patients have a reported history of e-cigarette product use, and no consistent evidence of an infectious cause has been discovered. Therefore, the suspected cause is a chemical exposure.
  • Most patients have reported a history of using e-cigarette products containing THC. Many patients have reported using THC and nicotine. Some have reported the use of e-cigarette products containing only nicotine.
  • No consistent e-cigarette or vaping product, substance, or additive has been identified in all cases, nor has any one product or substance been conclusively linked to lung disease in patients.
  • Initial published reports from the investigation point to clinical similarities among cases. Patients reported a history of e-cigarette use and had similar symptoms and clinical findings. These align with the CDC health advisory released August 30, 2019.
  • These investigations are ongoing. CDC will provide updates when more information is available.
*The previous case count was higher because it reported possible cases that were under investigation by states. The current number includes only confirmed and probable cases reported by states to CDC after classification.