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It is not a huge surprise, as most experts felt it was only a matter of time before the first UK Variant of COVID-19 (aka B.1.1.7) would be identified in the United States. This variant - which is believed to be more transmissible - has already turned up in Canada, Australia, Italy, Germany, Spain, Denmark, the Netherlands, Japan and a growing list of other countries.
This first case is a man in his 20's, with no recent travel history or known risk exposures, which suggests the variant is probably already circulating in the community.
While this is the first detection, we will probably start getting reports from other parts of the country as testing for this variant ramps up.
The announcement, from Colorado's Governor's office follows.
Gov. Polis and State Public Health Officials Announce First Case of COVID Variant of COVID-19 in ColoradoTUESDAY, DECEMBER 29, 2020
DENVER - Today, Gov. Polis and state health officials announced Colorado’s first case of the of COVID-19 variant B.1.1.7, the same variant discovered in the UK.
The Colorado State Laboratory confirmed and notified the Center for Disease Control (CDC) of the case. The individual is a male in his 20s who is currently in isolation in Elbert County and has no travel history.
Public health officials are doing a thorough investigation. The individual is recovering in isolation and will remain there until cleared by public health officials. The individual has no close contacts identified so far, but public health officials are working to identify other potential cases and contacts through thorough contact tracing interviews.
“There is a lot we don’t know about this new COVID-19 variant, but scientists in the United Kingdom are warning the world that it is significantly more contagious. The health and safety of Coloradans is our top priority and we will closely monitor this case, as well as all COVID-19 indicators, very closely. We are working to prevent spread and contain the virus at all levels,” said Governor Jared Polis. “I want to thank our scientists and dedicated medical professionals for their swift work and ask Coloradans to continue our efforts to prevent disease transmission by wearing masks, standing six feet apart when gathering with others, and only interacting with members of their immediate household.”
The Colorado state lab was the first in the country to quickly identify the variant through sophisticated analysis of testing samples. The lab initially performed the diagnostic PCR test on the sample and found that the sample was positive for COVID-19 with strong signals for the N gene and ORF1ab (both are detected when a person has COVID-19), but the signal for the S gene was not detected. When the S gene doesn’t register in the testing, it is called an “S Drop Out Profile,” and it is considered an essential signature for the variant.
The sample was flagged for further investigation. Scientists then sequenced the viral genome from the patient sample and found eight mutations specific to the spike protein gene associated with this variant. Genome sequencing is a molecular profiling of the entire viral RNA sequence.
Scientists in the United Kingdom believe the B.1.1.7 variant to be more contagious than previously identified strains of the SARS-CoV-2 variant, though no more severe in symptoms. In addition, the currently approved vaccines are thought to be effective against this variant.
“The fact that Colorado has detected this variant first in the nation is a testament to the sophistication of Colorado's response and the talent of CDPHE's scientist and lab operations,” said Jill Hunsaker Ryan, executive director, Colorado Department of Public Health and Environment. “We are currently using all the tools available to protect public health and mitigate the spread of this variant.”
Governor Polis and State officials will provide further details at a press conference tomorrow morning.
