COCA Call Today: Mpox - Clinical Management & Outbreaks

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Later today (2:00 PM – 3:00 PM ET) the CDC will hold a COCA call for clinicians on the continually evolving Mpox threat. The clade IIb outbreak which was declared a global health emergency in 2022 ended after only 10 months,  but we continue to see sporadic infections around the globe. 

At the same time a far more dangerous clade I mpox virus continues to rage in the DRC.

Last March a study was published Eurosurveillance: Ongoing Mpox Outbreak in South Kivu Province, DRC Associated With a Novel Clade I Sub-lineage, which contained the first genomic analysis of samples from a previously unaffected region of the DRC (the city of Kamituga). 

That study revealed a novel clade I sub-linage had emerged - most likely from a zoonotic introduction - with changes that may render current CDC tests unreliable.

In April, in Preprint: Sustained Human Outbreak of a New MPXV Clade I Lineage in Eastern Democratic Republic of the Congo, we saw a further analysis, which called for this new lineage to be named Clade Ib, and warned of its potential to spread globally. 

While that doesn't appear to have happened (yet), doctors are being asked to be particularly alert for cases with recent travel history to the DRC. 

These presentations are often technical, and are of greatest interest to clinicians and healthcare providers, but also may be of interest to the general public.

As always, If you are unable to attend the live presentation, these (and past) webinars are archived and available for later viewing at this LINK.

Mpox Update: Clinical Management and Outbreaks

= Free Continuing Education

Overview

The Centers for Disease Control and Prevention has been supporting the Democratic Republic of the Congo (DRC) in responding to its largest surge of clade I mpox (MPVX) cases ever recorded. Since January 1, 2023, DRC has reported more than 20,000 suspect mpox cases and more than 1,000 deaths. Clade IIb mpox continues to circulate in the United States but at much lower levels. The 2022 global clade IIb mpox outbreak caused more than 97,000 illnesses around the world, including more than 32,000 cases and 58 deaths in the United States.

During this COCA call, presenters will give updates on the clade I outbreak in DRC and remind clinicians to be alert for cases of mpox in patients with recent travel to DRC. Presenters will discuss when to suspect a case of mpox, provide updates on the clinical management and prevention of clade II mpox, discuss the epidemiology of clade II mpox, and cite vaccination data. They will also discuss the commercialization of the JYNNEOS vaccine and outline the update to the expanded access Investigational New Drug (EA-IND) for Tecovirimat (TPOXX).

Presenters

Agam Rao, MD
CAPT, U.S. Public Health Service
Chief Medical Officer for the Poxvirus and Rabies Branch
Division of High-Consequence Pathogens and Pathology
Centers for Disease Control and Prevention

Meghan Pennini, PhD
Chief Science Officer
HHS Coordination Operations and Response Element
Administration for Strategic Preparedness and Response
U.S. Department of Health and Human Services

Yon Yu, PharmD
CAPT, U.S. Public Health Service
Lead, Medical Countermeasures Regulatory Support Team
Office of Readiness and Response
Centers for Disease Control and Prevention

Call Materials

None at this time
Call Details

When:
Thursday, June 27, 2024
2:00 PM – 3:00 PM ET

Webinar Link:
https://www.zoomgov.com/j/1617016999

Webinar ID: 161 701 6999

Passcode: 059864

Telephone:
+1 669 254 5252, or, +1 646 828 7666

One-tap mobile:
+16692545252,,1617016999#,,,,*059864#

International numbers