Monday, October 21, 2024

Washington State: First Presumed Human Infections with H5 (n=4)

#18,352

Late Sunday afternoon the Washington State Department of Health announced that state's first presumptive positive human H5 infections in four poultry workers engaged in a cull in Franklin County (see Facebook announcement).

If confirmed by the CDC labs, this will bring the total number of human H5 cases in the United States in 2024 to 31, having more than doubled over the past 3 weeks.

Since the first of October, California has announced 13 cases linked to cattle exposure. Based on anecdotal reporting of symptomatic farm workers who were never tested - the official number of infected humans is likely an under count. 

As the following press release indicates, Washington State is testing additional individuals on the affected farm, and additional cases may be detected. 

First the full text from the Washington State Health Department, after which I'll return with more. 

First presumed human infections of avian influenza under investigation in Washington state

For immediate release: Oct 20, 2024 (24-122)

Contact: DOH Communications

First presumed human infections of avian influenza under investigation in Washington state

Workers developed symptoms after working with infected poultry


OLYMPIA – Four agricultural workers tested presumptively positive for avian influenza after working with infected poultry at a commercial egg farm in Franklin County. The individuals experienced mild symptoms and have been provided with antiviral medication. Testing of additional individuals on the farm is currently pending and the number of cases under investigation may change.

These are the first presumed human cases of H5 virus under investigation in Washington state. The cases took place at a farm that was the site of an avian influenza outbreak in chickens. About 800,000 birds were euthanized after test results by the Washington State Department of Agriculture on Oct. 15 showed that they were infected with avian influenza.

The Benton-Franklin Health District (BFHD) conducted health checks of exposed workers and coordinated testing at the Washington State Public Health Lab. The samples have been forwarded to the Centers for Disease Control and Prevention (CDC) for final confirmation and analysis of the virus.

Benton-Frankin Health District and the Washington State Department of Health (DOH) are working with the Washington State Department of Agriculture and the CDC on the regional response to this outbreak. DOH and BFHD have provided personal protective equipment to workers on the farm, are monitoring exposed workers for symptoms of avian influenza, and are providing testing, vaccines, and treatment for symptomatic workers.

Any employees or contractors who may have worked on a poultry farm in Benton or Franklin counties since Oct. 7 should contact BFHD at 509-460-4550 if they have symptoms such as red eyes or respiratory infections.
Washington is the sixth state to identify a human infection of H5N1. H5N1 highly pathogenic avian influenza (HPAI) has caused ongoing multistate outbreaks in poultry, dairy cattle, and wildlife.

“Washington has monitored the spread of H5N1 closely since it was first detected in poultry in the state in 2022, and our state is prepared with the knowledge, relationships, and tools to minimize its impacts on our community,” said Washington Secretary of Health Dr. Umair Shah.

The DOH has worked in partnership with the Washington State Department of Agriculture and the Washington Department of Fish and Wildlife to respond to detections of H5N1 in animals in the state, and to monitor the health of people exposed to infected animals. The DOH has worked with these animal health partners to distribute personal protective equipment and informational materials to dairy and poultry farmers.

Avian influenza is a disease caused by avian influenza Type A viruses that naturally occur in wild aquatic birds throughout the world. H5N1 viruses can also infect other species of birds, and occasionally mammals, and can cause significant mortality in poultry species, such as chickens, turkeys, pheasants, quail, ducks, geese, or guinea fowl.

On rare occasions, avian influenza viruses infect people and make them sick. Most instances of people becoming infected with avian influenza have happened after prolonged, close contact with animals infected with avian influenza or environments contaminated with avian influenza.
The CDC currently considers the risk to the general public from this H5N1 avian influenza to be low; however, people with job-related or recreational exposures to infected birds, cattle, or other potentially impacted domestic or wild animals are at higher risk and should take precautions,including wearing personal protective equipment.

DOH reminds the community to never handle or allow pets near dead birds. For more information on safety precautions, visit https://doh.wa.gov/avian-influenza.


While the news that all of these U.S. cases have produced relatively minor symptoms is encouraging, there are no guarantees that trend will continue.  Other H5Nx variants, in other regions of the world, have proved fatal in a large percentage of cases. 

Historically, the fall and winter herald the peak of avian and seasonal flu activity, and the next six months can be expected to produce more HPAI H5 outbreaks in cattle, poultry, and other species, along with increased spillovers into humans. 

The CDC has been recommending PPEs (Personal Protective Equipment) for farm workers for months (see below) - and state and federal agencies have been providing them for free - but the CDC has no legal authority to enforce compliance with these measures. 


Since wearing PPEs can be cumbersome and time consuming, we've seen considerable resistance from farmers in their use (see STAT news Farmers resist push for workers to wear protective gear against bird flu virus).

While it is unknown whether H5 has the capacity to produce a pandemic, every spillover into humans (and other mammalian species) provides the virus another opportunity to evolve and adapt into a more formidable foe. 

Which is why - mild or not - limiting the number of spillovers going forward should be of paramount importance to everyone.