Showing posts with label CCHF. Show all posts
Showing posts with label CCHF. Show all posts

Friday, July 04, 2014

UK PHE Reports Imported Case Of CCHF

image

Photo Credit- CDC

 

# 8805

 

A recurring theme in public health is just how quickly, and easily, that `exotic’ diseases can cross vast oceans or borders, given our modern air travel industry and our penchant for international travel (see The Global Reach Of Infectious Disease). 

 

The introduction of Chikungunya to the Caribbean last fall, and the ensuing (and ongoing) epidemic, are almost certainly the result of an infected traveler coming from an endemic region of the world.

 

Similarly the reintroduction of Dengue to South Florida in 2009, and the arrival of West Nile Virus in New York in 1999, are both thought to have arrived via infected international travelers, and both (probably after multiple introductions) have managed to gain a foothold in the United States.

 

More dramatically, but with less public health impact, earlier this year we saw the first North American importation of H5N in a nurse returning from China (see H5N1 In Canada: A Matter Of Import), while a few months later we saw Minnesota: Rare Imported Case Of Lassa Fever.

 

The good news is - despite their fearsome reputations - neither of these two diseases are easily spread between humans, and no secondary infections were reported.

 

The continual importation of measles has seen us go from the near-elimination of the virus in this country in 2000 to this year’s CDC Telebriefing: Worst US Measles Outbreak In 20 YearsAnd the most recent Arbovirus surveillance report lists thus far for 2014  the detection of 24 imported cases of Dengue, 52 imported cases of Chikungunya, and 20 imported cases of Malaria . . . in Florida alone.


Given this track record, no one should be terribly surprised to learn that the Public Health England reported yesterday their second known case of imported CCHF (Crimean-Congo Hemorrhagic Fever).   While CCHF can be transmitted from one human to another, it requires contact with infected blood or bodily fluids, and so it isn’t easily done.

 

 

Crimean-Congo haemorrhagic fever case identified in UK

From: Public Health England

History: Published 3 July 2014

Part of: Public health

PHE is aware of a laboratory-confirmed case of CCHF in a UK traveller who was bitten by a tick while on holiday in Bulgaria.

PHE sign

The patient is responding well to treatment and there is no risk to the general population.

As a precautionary measure, close contacts of the patient, including hospital staff involved in the patient’s care, will be given health advice and encouraged to contact their GP if they experience symptoms.

Although Crimean-Congo haemorrhagic fever (CCHF) can be acquired from an infected person, this would require direct contact with their blood or body fluids and the risk even for close contacts is considered very low.

This is the second laboratory-confirmed case of CCHF in the UK, following the diagnosis in 2012 of CCHF in a UK resident who had recently returned from Afghanistan.

CCHF is the commonest viral haemorrhagic fever worldwide. It is not found in the UK but is endemic in many countries in Africa, the Middle East, Asia and Eastern Europe, including Turkey and Bulgaria.

People most at risk are agricultural workers, healthcare workers and military personnel deployed to endemic areas. CCHF is most often transmitted by a tick bite but can also be spread through contact with infected patients or animals.

Dr Tim Brooks, Head of Public Health England’s (PHE’s) Rare and Imported Pathogens Laboratory (RIPL) said:

It’s extremely rare to see a case of Crimean-Congo haemorrhagic fever in the UK, and it’s important to note there is no risk to the general population. As a precaution, close contacts of the patient will be contacted and monitored, but the risk of transmission is very low and would require direct contact with bodily fluids.

 

 

The first imported case of CCHF in the UK, mentioned above, was a 38-year old man who flew into Glasgow, Scotland from the Middle East (see Update: CCHF Patient In Scotland Dies).

 

While uncommon in Western Europe, this tickborne virus is widely distributed across parts of Eastern Europe, the former Soviet Union, the Mediterranean, central Asia, southern Europe, Africa, the Middle East, and the Indian subcontinent.

image

Credit WHO

 

CCHF is a Nairovirus in the family Bunyaviridae, and was first described in the Crimea in 1944.  Later it was also isolated in the Congo (1969) – hence the name.

 

CCHF is normally transmitted to humans via the bite of a tick, or via contact with the blood of infected animals, although there have been reports of nosocomial (in hospital) transmission as well (see 2010  WHO report on Pakistan).

 


Today’s story isn’t so much about one rare imported case of CCHF, but about how important it is that we anticipate, and prepare for, the inevitable arrival of many more imported diseases. 

 

Which is why the CDC, along with other international public (and animal) health agencies are involved in a series of initiatives to improve global health surveillance & emergency response in this age of rising infectious diseases.  The rationale for which is explained on the CDC’s Global Health Website at:

 

Why Global Health Security Matters

Disease Threats Can Spread Faster and More Unpredictably Than Ever Before

(Excerpt)

A disease threat anywhere can mean a threat everywhere. It is defined by

  • the emergence and spread of new microbes;
  • globalization of travel and trade;
  • rise of drug resistance; and
  • potential use of laboratories to make and release—intentionally or not—dangerous microbes.

(Continue . . .)

Saturday, October 06, 2012

Update: CCHF Patient In Scotland Dies

 

image

Global Distribution of CCHF – Credit WHO

 

# 6612

 

News this morning from the UK press that the 38-year old man who flew into Glasgow, Scotland earlier this week from the Middle East infected with CCHF (see Crimean-Congo Hemorrhagic Fever Patient Isolated In Glasgow) has died overnight.

 

This report from the Independent, after which, I’ll have more.

 

Patient with rare fever dies in UK hospital

Lucinda Cameron  - Saturday 06 October 2012

A man being treated for Crimean-Congo haemorrhagic fever after returning to the UK from Afghanistan has died.

 

It is the first laboratory-confirmed case of CCHF in the UK, according to the Health Protection Agency (HPA).

 

Other passengers who sat close to him on an aircraft are undergoing daily health checks.

(Continue . . . )

 

 

Although originally hospitalized at Gartnavel General Hospital's Brownlee Centre, the unidentified patient was transferred yesterday to a high bio-security unit at London's Royal Free Hospital yesterday.

 

The following statement from the HPA was released yesterday, before the patient’s death.

 

Confirmed case of Crimean Congo Haemorrhagic Fever in the UK

5 October 2012

The Health Protection Agency (HPA) is aware of a laboratory confirmed case of Crimean-Congo Haemorrhagic Fever (CCHF) in a UK traveller who has recently returned from Afghanistan. The patient has been transferred from Glasgow, Scotland to the high security infectious diseases unit at the Royal Free hospital in London using specialist air transport.

CCHF is a serious viral disease which infects a range of domestic and wild animals. Humans are usually infected directly from the blood or body fluids of infected animals or via tick bites. The disease is endemic in many countries in Africa, parts of Europe, the Middle East and Asia.

CCHF can be acquired from an infected patient, but this requires direct contact with their blood or body fluids Therefore, there is no risk to the general population. As a precautionary measure, close contacts of the patient including hospital staff involved in the patient’s care have been contacted and will be monitored.

The HPA is providing public health, diagnostic and other support to the teams currently handling this incident.

This is the first laboratory-confirmed case of CCHF in the United Kingdom.

  • Information about the Crimean-Congo Haemorrhagic Fever is available on the HPA website. 
  • Information about the geographical distribution of CCHF is available on the HPA website.
  • Further information about the transmission of CCHF is available on the HPA website.
  • Information on CCHF is available from the World Health Organization (WHO) website [external link].
  • Visit the Royal Free Hospital website [external link].
  •  

    While the risk that this virus has been spread to others is considered low, the HPA will monitor close contacts of this patient for the next two weeks looking for any signs of infection.

    Monday, October 25, 2010

    WHO On Cholera/CCHF/Dengue Outbreaks In Pakistan

     

     



    # 5010

     

     


    Two updates today from the World Health Organization on the ongoing outbreaks of several infectious diseases in Pakistan.

     

    First, Cholera – which like in Africa and now Haiti, has also been sporadically reported in the flood affected provinces of Sindh, Punjab and Khyber Pakhtunkhwa.

     

    Cholera in Pakistan

    25 October 2010 -- On 12 October 2010, the Ministry of Health in Pakistan reported laboratory confirmation of 99 cases of Vibrio cholera 01 in the country. These cases were laboratory-confirmed by the National Institute of Health since the beginning of the flood until 30 September 2010. These cases have been reported sporadically from a wide geographical area in the flood-affected provinces of Sindh, Punjab and Khyber Pakhtunkhwa.

     

    The Ministry of Health in Pakistan supported by the World Health Organization and other local and international partners are collaborating closely to prevent outbreaks of any disease, including cholera, and treat people affected by such illnesses. More than 60 diarrhoeal treatment centres are either operating or are soon to start functioning in the 46 most affected districts of the country.

     

    Diarrhoeal diseases including cholera are among the most reported health conditions in many locations affected by the recent floods disaster in the country.

    FOR MORE INFORMATION
    WHO cholera Fact sheet
    WHO Pakistan web site

     

     

    Next, since the end of September we’ve been watching reports of heightened transmission of CCHF – normally a tick-borne illness – being reported in several areas of Pakistan. 

     

    As you can see from this WHO map, CCHF is not uncommon in this part of the world.

     

    image

     

    While I’ve been tempted to blog on this outbreak for a couple of weeks, quite frankly the reports I’ve seen have been inconsistent and confusing.

     

    Over the past month we’ve suggestions of nosocomial transmission among health care workers, denials, retractions, and revisions of numbers as these ProMed Mail dispatches demonstrate.

     

    PRO/AH/EDR> Crimean-Congo hem. fever - Pakistan (09): (NW)

    PRO/AH/EDR> Crimean-Congo hem. fever - Pakistan (08): (PB), not

    PRO/AH/EDR> Crimean-Congo hem. fever - Pakistan (07): revised data, WHO

    PRO/AH/EDR> Crimean-Congo hem. fever - Pakistan (06): (PB)

    PRO/AH/EDR> Crimean-Congo hem. fever - Pakistan (05): (NW)

    PRO/AH/EDR> Crimean-Congo hem. fever - Pakistan (04): (PB)

    PRO/AH/EDR> Crimean-Congo hem. fever - Pakistan (03): (PB) nosocomial

     

     

    Today, a rather generic update from the WHO that suffers from a lack of detail. 

     

    Nothing is said about exactly where these cases occurred, or about the mode of transmission, leaving much uncertainty.

     

    Things are, however, still in a state of flux in the wake of the unprecedented flooding disaster last month in that nation, and so some of this ambiguity may be understandable. 

     

     

    Crimean-Congo haemorrhagic fever (CCHF) and Dengue in Pakistan

    25 October 2010 -- As of 15 October, the IHR National Focal Point, Ministry of Health (MoH), Pakistan, has notified WHO of 26 cases, including 3 deaths, of Crimean-Congo haemorrhagic fever (CCHF). In addition, over 1500 laboratory-confirmed cases of dengue fever including 15 deaths have also been reported from Pakistan so far.

     

    Both CCHF and dengue fever are endemic in Pakistan with seasonal rise in cases. However, recently, the transmission of both CCHF and dengue fever has intensified in the country with increased incidence and geographic expansion. The recent Pakistan floods may have contributed to this upsurge as a result of changes in risk factors for these diseases.

    Operational response

    The MoH has scaled up response activities to prevent and mitigate CCHF and dengue fever, including awareness-raising campaigns on exposure risks and preventive measures for the general public, strengthening clinical and case management of patients with haemorrhagic fevers, stockpiling appropriate drugs and personal protective equipment, and implementing targeted vector control activities.

     

    Upon request from the MoH in Pakistan, WHO is mobilizing experts in the clinical management of severe dengue fever and in infection control in health care settings through the Global Outbreak Alert and Response Network (GOARN). WHO is also assisting the country with resource mobilization, strengthening disease surveillance, laboratory diagnostics, and training of health care providers.

    FOR MORE INFORMATION
    WHO dengue website
    WHO CCHF website