EM&I: Limited added benefit of seasonal influenza vaccination before A(H5) vaccination in mice and ferrets challenged with A(H5N1)

 

Credit ACIP/CDC

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One of the biggest challenges during any future H5Nx pandemic would be the rapid production and timely deployment of a two-dose (given 30 days apart) H5 vaccine to billions of people (see Referral: SCI AM - A Bird Flu Vaccine Might Come Too Late to Save Us from H5N1).  

While it's not a new idea (see 2008's Seasonal Flu Vaccine May Offer Some Protection To H5N1), the notion of using the existing seasonal flu vaccine as either a `stop-gap measure' - or as a `prime-boost' for the first pandemic jab, during the opening months of an H5 pandemic - has persisted. 

An early, encouraging 2010 study in the journal Vaccines (Seasonal influenza vaccine elicits heterosubtypic immunity against H5N1 that can be further boosted by H5N1 vaccination) reported:

Recent findings indicate that seasonal influenza vaccination or infection of healthy humans may contribute to heterosubtypic immunity against new influenza A subtypes, such as H5N1. Here, we investigated whether seasonal influenza vaccination in a mouse model could induce any immunity against the H5N1 subtype.

It could be demonstrated that, largely due to the H1N1 component strain A/NewCaledonia/20/99, parenteral immunization of mice with a trivalent seasonal influenza vaccine elicited heterosubtype H5-reactive antibodies able to confer partial protection against H5N1 influenza virus infection.

Furthermore, the trivalent seasonal influenza vaccine was found to be compatible with a whole virus H5N1 vaccine in a heterologous prime-boost immunization regimen, achieving superior efficacy compared to a single immunization with an equivalent low-dose of the H5N1 vaccine.

More recent evidence remains both mixed and modest - and has often relied on ferret or mouse models (which may not fully apply to humans) -  including:

Nature Comms: Adjuvanted Influenza Vaccination Increases Pre-existing H5N1 Cross-reactive Antibodies

mBio: Low levels of influenza H5N1 HA and NA antibodies in the human population are boosted by seasonal H1N1 infection but not by H3N2 infection or influenza vaccination

EID Journal: Effect of Seasonal Influenza Vaccines on Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Ferrets

EID Journal: Investigation of Influenza A(H5N1) Virus Neutralization by Quadrivalent Seasonal Vaccines, United Kingdom, 2021–2024

Note: Regardless of whether the seasonal flu vaccine directly protects against H5N1 infection, there are still good reasons to get the jab, prior to - and even during - an H5Nx pandemic.

1. It still may provide some small boost to your immune response.  Neutralizing antibodies aren't the only immune defense against infection. 
2. It could help prevent a co-infection with H5N1 and seasonal flu, which has the potential for being more severe.
3. Co-infections could also help generate a reassorted `hybrid' virus (see Preprint: Intelligent Prediction & Biological Validation of the High Reassortment Potential of Avian H5N1 and Human H3N2 Influenza Viruses).

While it may not be the last word on the topic, today we've a study in EM&I from researchers at the CDC's NCIRD Influenza Division, which frankly, offers little encouragement on the effectiveness of using seasonal flu vaccines as a `prime-boost' for H5N1 vaccines. 

I've only reproduced the abstract and a few excerpts, so follow the link to read the report in its entirety.  I'll have a brief postscript after the break.

Limited added benefit of seasonal influenza vaccination before A(H5) vaccination in mice and ferrets challenged with A(H5N1)

Masato Hatta , Ying Huang , Jeremy A. Duke , Joseph R. Rouse , Chenchen Feng ,
Xudong Lin , show all
Article: 2731495 | Received 29 Jun 2026, Accepted 05 Sep 2026, Published online: 21 Sep 2026
 https://doi.org/10.1080/22221751.2026.2731495

Limited A(H5)-specific vaccine supply is expected early in a potential A(H5N1) pandemic, raising the question of whether licensed seasonal influenza vaccines could enhance protection when administered before A(H5) vaccination. We evaluated this strategy in mouse and ferret models using clade 2.3.4.4b A(H5N1) viruses.

Seasonal influenza vaccination induced antibodies to seasonal haemagglutinins but did not induce detectable antibodies against A(H5) and did not consistently enhance A(H5)-directed antibody responses after A(H5) vaccination.

In lethal challenge studies, seasonal vaccine priming before A(H5) vaccination was associated with improved outcomes compared with A(H5) vaccination alone in one of three mouse experiments, but this effect was not observed in the other two mouse experiments or in ferrets. These findings suggest that seasonal influenza vaccine priming provides limited added benefit to A(H5) vaccine-mediated protection against A(H5N1) under the conditions tested.

(SNIP)

Accordingly, clinical studies are needed to further evaluate the strategy of administering seasonal influenza vaccine prior to A(H5) vaccination. However, such studies would likely rely on immunological endpoints rather than direct assessment of protection. Evidence of cross-reactivity alone should therefore be interpreted cautiously when informing decision-making, as it may not reliably predict protection against severe or lethal A(H5N1) infection.

In the absence of a clear added benefit, prioritizing seasonal influenza vaccination as a priming strategy to enhance protection against A(H5N1) during the early phase of a pandemic may offer limited value, particularly when resources may need to be directed toward A(H5)-specific vaccination and other countermeasures. Continued efforts to improve the development, availability, and deployment of antigenically similar A(H5) vaccines should remain a priority for pandemic preparedness [13,14].

       (Continue . . . )

Although the prospect of using seasonal vaccine as a bridge - or as a primer for a first H5 dose - remains biologically plausible, the evidence of its effectiveness has been both inconsistent and weak. 

Today's CDC study reports that prior seasonal vaccination offered little reproducible improvement over H5 vaccination alone (at least, in mice and ferrets). While disappointing, it is hardly unexpected. 

Which suggests that during the opening months of any novel flu pandemic we will (once again) have to rely on NPIs (Non-pharmaceutical Interventions) like social distancing and face masks - and our limited supply of antivirals -  while a strain-specific vaccine is produced and deployed.

For some specific preparedness advice, you may wish to revisit #Natlprep 2026: Pandemic Planning At Both Ends of the Spectrum. 

California Declares State of Emergency to Bolster Statewide El Niño Preparedness

 

#19,344

Earlier this month, in #NPM26: Preparing For An El Niño Winter,  we looked at the potential for weather anomalies across the country due to a strengthening - and possibly historic - El Niño expected this winter. 

Predicting exactly where or when unusual or severe weather will occur due to El Niño is impossible, but typically, during El Niño the jet stream across the United States shifts storm tracks to the southern tier of states.

While that may mean more more snow or ice for the southern tier of states, heavy rains and possible severe weather across the Gulf states, while warmer and drier in the north - for California this often means repeated atmospheric rivers - bringing bringing flooding rains and a heavy Sierra snowpack. 

How bad any of these scenarios will play out is anyone's guess. Weather is complicated - and while this winter's El Niño could be unprecedented - there are no hard and fast rules about its effects.

Yesterday, the Governor of California declared a State of Emergency to aid in statewide preparation for El Niño's arrival later this year.  He also proclaimed a state of emergency in several states due to recent storm activity. 

I've only reproduced a brief excerpt from the announcement. Follow the link to read the statement in its entirety.  

        Sep 21, 2026

Governor Newsom proclaims state of emergency to bolster statewide El Nino preparedness, protect California

Proclaims states of emergency in several counties to support recovery from earlier storm activity and other events

What you need to know: Governor Newsom is taking early action to prepare California for what is shaping up to be a historic El Niño season, which is forecast to be very strong, even the strongest on record. The state of emergency helps California move faster to protect communities, stage critical resources, and strengthen readiness before severe weather intensifies.

SACRAMENTO – As a historic El Niño storm season develops, Governor Newsom is proclaiming a state of emergency today, mobilizing state resources ahead of potential winter storms and other impacts. The emerging El Niño event is already breaking records, and forecasters expect it to continue to strengthen, potentially becoming the strongest in recorded history. Today’s emergency proclamation streamlines measures to help California prepare for this historic event.

The Governor’s action puts California in a stronger position before winter weather intensifies. It directs state agencies to begin protecting vulnerable communities, prepare roads and critical infrastructure, stage emergency supplies, and help local partners reduce flood, landslide, and coastal risks.

Read the full proclamation here.

        (Continue . . . )
 

Those interested in diving into one of the more extreme (albeit, historic) scenarios of Atmospheric river flooding may wish to revisit 2022's California's ARkStorm Scenario Revisited & National Preparedness Month, but even a far less severe event could be devastating. 

While California may be first in line to feel El Niño's effects, ill effects, it won't be alone. So, if the power goes out, or flood waters rise, or the ground begins to shake . . . do you already have?

• A battery operated NWS Emergency Radio to find out what was going on, and to get vital instructions from emergency officials
• A decent first-aid kit, so that you can treat injuries
• Enough non-perishable food and water on hand to feed and hydrate your family (including pets) for the duration
• A way to provide light when the grid is down.
• A way to cook safely without electricity
• A way to purify or filter water
• A way to handle basic sanitation and waste disposal.
• A way to stay cool (fans) or warm when the power is out.
• A small supply of cash to use in case credit/debit machines are not working
• An emergency plan, including meeting places, emergency out-of-state contact numbers, a disaster buddy, and in case you must evacuate, a bug-out bag
• Spare supply of essential prescription medicines that you or your family may need
• A way to entertain yourself, or your kids, during a prolonged blackout

If not, you've got some important work to do.

A good place to get started is by visiting Ready.gov, or by hitting this link which will serve up a series of my preparedness blogs.

While being prepared can't guarantee you a good outcome, it can certainly increase your chances.

Preprint: Serological Evidence of Widespread Exposure to H5 Avian Influenza Virus in Arctic Foxes in Svalbard, Norway

Location of Svalbard in the Arctic Ocean

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The Svalbard Archipelago, located well above the Arctic Circle - roughly midway between the northern coast of Norway and the North Pole - is about the size of West Virginia and is home to fewer than 3,000 people.

Since 2022, Svalbard has also become a frequent center of HPAI H5 activity, reporting a mixture of  H5N1 and H5N5 (see Norwegian Veterinary Institute : HPAI Detected In Arctic (Svalbard) For the First Time).

This becomes all the more important because Svalbard - like many high-latitude avian nesting regions - is the summer home for millions of  migratory seabirds, waterfowl, waders, and other birds. As we saw in 2016's Sci Repts.: Southward Autumn Migration Of Waterfowl Facilitates Transmission Of HPAI H5N1, it is thought that these breeding areas may contribute to viral evolution and global spread of new reassortants. 

As we discussed in 2025's H5Nx: Reassort & Repeat, each fall we watch for the introduction of new genotypes and/or subtypes with the autumn arrival of migratory birds. 

We revisited the Svalbard story again in 2024's HPAI H5N5: A Variation On A Theme, and over the past few months, we've also seen extensive reporting on the detection of  H5N5 in polar bears in the region. 

Norwegian Veterinary Institute Reports Another HPAI H5N5 Infected Polar Bear on Svalbard Island

Preprint: HPAI H5N5 in a Polar Bear and Atlantic Walrus, Svalbard, 2026, with Widespread Seroconversion in Polar Bears

Norway Veterinary Institute Reports HPAI H5N5 In Polar Bears on Svalbard Island

 

While most of the world continues to deal primarily with clade 2.3.4.4b HPAI H5N1, since 2023 we've been following a relatively small - but persistent - presence of H5N5 in Northern Europe, Iceland, Eastern Canada, and even the Pacific Northwest. 

Credit: Multiple transatlantic incursions of HPAI 

clade 2.3.4.4b A(H5N5) virus into North America and spillover to mammals

Like H5N1, H5N5 appears to have an affinity for spilling over into mammalian species, including seals, walruses, polar bears, raccoons, mink, deer, domestic cats, and humans (n=1). 

While these infections often prove fatal, we've also seen growing serological evidence of non-lethal infection. 

In August of 2025, the Norwegian Veterinary Institute reported the first detection of H5N5 in Arctic Foxes on Svalbard Island.  Their press release stated: 

Arctic foxes can become infected with avian influenza through direct contact with sick or dead animals. Foxes are scavengers that are exposed to high infection pressure when they eat infected birds. Studies of red foxes on the mainland indicate that foxes do not have the ability to infect each other. Whole-genome sequencing of the viruses from arctic fox pups will be carried out to investigate whether there are signs of mammalian adaptation in the viruses.

This week researchers from the Norwegian Veterinary Institute have published a follow-up, in the form of a 26-page preprint, documenting serological evidence of widespread H5 exposure among Svalbard's population of  Arctic foxes. 

Due to its length I've only posted some excerpts (reformatted for readability), so you'll want to follow the link to read it in its entirety. I'll have a bit more after you return.

Serological Evidence of Widespread Exposure to H5 Avian Influenza Virus in Arctic Foxes in Svalbard, Norway

Johanna Hol H Fosse, Eva Fuglei, Francesco Bonfante, Line Olsen, Luca Bordes, Rebecca K. Davidson, Torill Mork, Ida Kristin Myhrvold, Lone Thiel Engerdahl, Sandra Venema, Kjersti Sturod, Johan Akerstedt, Olav Hungnes, Monika Z. Ballmann, Lineke Begeman, Ingebjorg Helena Nymo, Ragnhild Tonnessen, Bjornar Ytrehus
doi: https://doi.org/10.64898/2026.09.17.752278
This article is a preprint and has not been certified by peer review [what does this mean?].
 
Preview PDF

Abstract

The continued circulation of H5 clade 2.3.4.4b highly pathogenic avian influenza virus (HPAIV) has caused extensive mortality in wild bird populations worldwide with increasing spillover to mammals. In 2022, H5 HPAIV emerged in Svalbard, Norway, with subsequent detections in wild birds, walruses, polar bears, and arctic foxes. 

To understand the population-level exposure among Svalbard arctic foxes, we analysed body fluids from carcasses trapped in 2006-2015 (n = 56), 2023-2024 (n = 112), and 2024-2025 (n = 94) for antibodies to H5 avian influenza (anti-H5), influenza A nucleoprotein (anti-NP), and neuraminidase subtypes using ELISAs, haemagglutination inhibition (HI), and a multiplex assay.

• Only three samples from 2006-2015 tested positive for anti-H5 and were interpreted as false positives.  
• In 2023-2024, seropositivity for anti-H5 was high (95%), supported by a lower anti-NP seropositivity (85%) and antibody profiles consistent with mixed H5N1 (42%) and H5N5 (52%) exposure. 
• In 2024-2025, anti-H5 and anti-NP seroprevalences remained high (83% and 57%), with H5N5 (87%) exposure predominating over H5N1 (3%). 

A subset of anti-H5-positive samples tested positive by HI (2023-2024: 30%; 2024-2025: 14%). Juveniles with exposure limited to the previous season had higher odds of anti-H5 seropositivity in 2023-2024 than in 2024-2025 (OR 5.5). Analysis of paired lung extracts from a subset of individuals (n = 63) yielded results concordant with body fluids, using an indirect anti-H5 ELISA adapted for carnivores. Our findings demonstrate widespread H5 virus exposure. 

Together with occasional reports of progression to fatal HPAI, this highlights the need for continued population monitoring to evaluate ecological consequences.

       (SNIP)

Discussion

Our study reveals widespread exposure to H5 avian influenza in Svalbard arctic foxes trapped during the winters 2023-2024 and 2024-2025, with no evidence of H5 exposure during the preemergence period (2006-2015), as the few anti-H5-positive results detected in that period were interpreted as likely false positives.

Antibody profiles changed over time, suggesting a transition from mixed H5N1 and H5N5 exposure in 2023-2024 to predominantly H5N5 exposure in 2024-2025.

Our findings demonstrate that many arctic foxes survive exposure to H5 avian influenza viruses and develop a detectable humoral response. However, recent detections of fatal HPAI in arctic fox pups suggest that the virus may have profound effects in some individuals, although its potential effects on population dynamics remain unknown. The temporal changes in antibody profiles should be viewed in the context of HPAIV detections in Svalbard wildlife. Both H5N1 and H5N5 viruses were detected in birds and marine mammals in 2023, whereas no detections were reported in 2024. However, H5N5 was subsequently detected in arctic foxes in 2025 and in a polar bear and an Atlantic walrus in 2026 [13,18].

        (SNIP)

In conclusion, our findings demonstrate widespread exposure of Svalbard arctic foxes to H5 avian influenza virus following the emergence of clade 2.3.4.4b viruses in the High Arctic, with unknown consequences for the population. The exceptionally high seroprevalence, combined with temporal changes in antibody profiles, indicates substantial and evolving exposure within the Svalbard ecosystem. Arctic foxes may represent a useful sentinel species for monitoring HPAIV circulation in remote regions where conventional surveillance is challenging.

Continued integrated surveillance of wildlife hosts, predators, and scavengers will be important for understanding the long-term ecological consequences of HPAIV circulation and for detecting future changes in virus distribution, subtype composition, and transmission dynamics [18].

        (Continue . . . )

Interestingly, while H5N1 remains the dominant HPAI across the rest of the world, in Svalbard (and potentially other poorly-monitored high-latitude regions); H5N5 appears to have - at least temporarily - gained the upper hand. 

It’s not yet clear whether H5N5’s apparent success in Svalbard reflects some inherent viral advantage, favorable local environments or hosts, or simply chance.

But it's an outlier, which makes it well worth our continued attention.  

Emerg. Microbes & Inf.: Novel emerging reassortant H6 avian influenza viruses with internal genes from G57 genotype of H9N2 pose potential zoonotic risk

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A little over a year ago, in JOI: Prevalence and Transmission of Influenza A (H6) Viruses Pose a Potential Threat to Public Health, we revisited the H6 family of influenza A viruses, which are endemic in Asian poultry and are believed to have some degree of zoonotic potential. 

Long time readers will recall that H6N1 briefly made headlines in 2013 and 2014 after a college student in Taiwan was hospitalized with pneumonia (see Taiwan CDC: Epidemiological Analysis Of Human H6N1 Infection) and several dogs were found infected (see EID Journal: Influenza A(H6N1) In Dogs, Taiwan).

But as an LPAI virus (and neither H5 or H7), it isn't considered a `reportable' disease in poultry or wild birds by WOAH, and therefore our knowledge of its spread and evolution is limited.  

That said, over the past decade we've seen growing interest by Chinese scientists in the spread and evolution of H6, particularly since it reassorts readily with another zoonotic risk: LPAI H9N2.  A sampling of recent blogs include:

J. Inf.: Zoonotic Threat of Novel H6N2 Avian Influenza Virus with Internal Genes Exclusively Derived from H9N2, China, 2025

Preprint: Progressive Adaptation of H6N1 Avian Influenza Virus in Taiwan Enhances Mammalian Infectivity, Pathogenicity and Transmissibility

Study: Influenza A (H6N6) Viruses Isolated from Chickens Replicate in Mice and Human lungs Without Prior Adaptation

H9N2 is a ubiquitous, and highly promiscuous avian influenza virus, which reassorts easily with other influenza A strains and has a record of lending its internal genes to more dangerous HA subtypes (see PNAS: Evolution Of H9N2 And It’s Effect On The Genesis Of H7N9).

Today's study describes 6 H6 reassortants - all carrying the internal genes from H9N2 - and 5 with its NA from H5N1, and 1 from H9N2.  Of note, the H6N2 isolate showed dual receptor binding to both avian and human-like receptor cells. 

The three representative isolates tested (NJ2501, AH25107, and CZ56) produced high virulence in mice, while all 6 produced respiratory symptoms in chickens, and transmitted efficiently among birds.

Due to its length and technical nature, I've only posted some excerpts. Follow the link to read the report in its entirety.  I'll have a postscript after you return.

Novel emerging reassortant H6 avian influenza viruses with internal genes from G57 genotype of H9N2 pose potential zoonotic risk

Zhimin Wana,b,c,d*, Wenjie Jianga,b,c,d*, Xudong Caoa,b,c,d, Xingyao Guoa,b,c,d, Xinyan Hea,b,c,d, Jianjun Zhange,Xinran Chua,b,c,d, Xinyi Jia,b,c,d, Yu Liua,b,c,d, Xuefeng Yina,b,c,d, Zhehong Zhaoa,b,c,d, Jixiang Wanga,b,c,d,Wei Gaoa,b,c,d, Quan Xiea,b,c,d, Tuofan Lia,b,c,d, Hongxia Shaoa,b,c, Aijian Qina,b,c, Yuhai Bif,g,h andJianqiang Yea,b,ca 

In recent decades, multiple novel reassortant avian influenza viruses (AIVs) carrying internal genes derived from H9N2 viruses have emerged in poultry in China and have repeatedly caused human infections, highlighting the pivotal role of the H9N2 internal genes cassette in facilitating cross-species transmission. 

In this study, five H6N1 and one H6N2 AIVs were isolated from chickens and Houdan chickens exhibiting respiratory symptoms. Genetic analyses revealed that the hemagglutinin (HA) genes of these H6 AIVs belonged to the ST339-like lineage and originated from H6 AIVs circulating in domestic geese in China, whereas the neuraminidase (NA) genes were derived from H9N2 or H5N1 AIVs, respectively. 

Notably, all six internal genes of these H6 isolates were derived from the G57 genotype H9N2 virus. In vitro studies demonstrated that these H6 AIVs replicated effectively in both avian and mammalian cells.

The H6N2 isolate displayed dual receptor binding affinity for both avian-like and human-like receptors, whereas the five H6N1 viruses showed no detectable receptor binding affinity under the assay conditions in vitro. Reverse-genetics reassortant assay further revealed that the H6N1 HA itself possesses intrinsic dual receptor binding affinity.

Furthermore, these H6 isolates exhibited high virulence in mice, and induced obvious respiratory symptoms in chickens, with efficient transmission among birds. 

Collectively, our findings demonstrate that H6 AIVs carrying the G57 H9N2 internal gene constellation are actively circulating in chicken populations and pose a substantial threat to poultry health, underscoring their potential risk to public health and the need for continued surveillance at the poultry-human interface.

(SNIP)

Discussion 

The  continuous emergence of the novel reassortant AIVs poses a great threat to both poultry industry and public health. In this study, we identified and characterized six novel reassortant H6N1 and H6N2 AIVs circulating in chickens with respiratory symptoms, all of which harbour internal genes from the G57 genotype H9N2 virus. 

Our findings provide further evidence that H9N2 viruses serve as a critical genetic backbone facilitating the generation of novel reassortant AIVs with enhanced fitness in poultry and increase zoonotic potential.

(SNIP)

In addition to their mammalian pathogenicity, these H6 viruses demonstrated efficient infection and transmission in chickens. Viral shedding was detected in both infected and contact chickens (Figure 8), indicating effective direct-contact transmission of these novel H6 viruses. The ability to spread efficiently within poultry is a critical factor for viral maintenance and amplification, which increases the likelihood of further reassortment and spill-over events. 

Compared with previous reports in which H6 viruses showed limited transmission in poultry [26], the strains described here appear to have acquired enhanced transmissibility, possibly due to their adapted internal genes of H9N2 virus origin.

        (SNIP)

In conclusion, our study highlights the evolution of H6 AIVs through reassortment with G57 genotype H9N2 viruses and demonstrates that such reassortment can result in AIVs with enhanced pathogenicity and cross-species transmission potential. 

These findings underscore the importance of continuous surveillance of AIVs in poultry flocks in China, particularly those carrying H9N2 internal genes, as they may serve as precursors to zoonotic or even pandemic AIVs.

       (Continue . . . )

While most people think first of `H5N1' when they hear about novel flu strains, the CDC's IRAT lists 27 avian, canine, or swine subtypes/variants with pandemic  potential.  

Among the top 10 zoonotic influenza A viruses (ranked by likelihood of emergence) the CDC has placed H5N1 as 7th on the list, while H9N2 comes in at #5.

And despite having caused documented human infections, a number of novel flu subtypes (e.g. H3N8, H5N5, H6N1, and H7N4) have yet to be added to this list. 

The reality is, most of these viruses will never pose a serious public health threat.  But none of them can be ruled out as having pandemic potential.

 Which is why we follow their progress with considerable interest.  

#NPM26: It's a 12 Volt Life

CDC Infographic

Note: This is the 20th day of National Preparedness Month. Follow this year’s campaign on Twitter by searching for the #NatlPrep #BeReady or #PrepMonth hashtags.

This month, as part of NPM26, I’ll be rerunning some updated preparedness essays, along with some new ones.

#19,341

Most disasters boil down to unscheduled camping - for days, or sometimes weeks - in your home, in a community shelter, or possibly even in your own backyard.

Preparedness can not only make that process possible, it can make it far less miserable as well. 

But, as anyone who has ever tried to buy a loaf of bread or a gallon of milk after a hurricane or blizzard warning has been issued already knows, prepping has to be done well before a disaster looms.

And quite frankly, given the rates of inflation and other global uncertainties, it seems likely that whatever you'd pay today for prep items will be higher in the future.  And that assumes they will still be available. 

If you have unlimited funds, and plenty of room, you can prep in style.  But most people are constrained by limited budgets, and other restraints, and so this list is primarily for them. 

Living in hurricane country, my biggest concerns revolve around prolonged power outages, which also can impact other utilities (including water, sewer, and internet). 

• Following last 2024's one-two punch from Hurricanes Helene & Milton, I got my power back after only 4 days (although internet took a week). Before that, I went nearly a week without power following Irma in 2017, but many people had it far worse (most of Puerto Rico was without power for months after hurricane Maria in 2017).

• Not quite five years ago, in February of 2021, 3 successive winter storms swept across Texas, Louisiana, and Oklahoma, causing the worst collapse of the Texas energy grid on record (see Texas: The Latest - But Not The Last - Grid Down Crisis), resulting in hundreds of deaths (see City of Austin & Travis County 2021 WINTER STORM URI AFTER-ACTION REVIEW).

• And just last July, the U.S. Department of Energy published a 73-page report that warns that if current schedules for retirement of reliable power generation (especially baseload) continue, without enough firm replacement, the risk of blackouts in 2030 could increase by 100× over current levels.

While those with tens of thousands of dollars to spend can have a whole-house solar system or generator - one capable of running freezers, refrigerators, and air conditioners - even a small budget system can make life without grid power a little more bearable.

My minimum goal is to have enough sustainable power for lights, radio, phone charging, a personal MP3 player, and fans. Trying to run appliances, HVAC, or other high-draw devices is simply beyond my budget (but if you have enough money . . . . it can be done ).

The following is an example of how one can put together a basic plug-and-play mini solar power system for around $100; one that will keep phones, lanterns, and some mini-fans charged and running for days.

While I'm not recommending specific brands or suppliers, these photos are all typical of items I've purchased and used myself. 

This is my `bug out' solar kit; What I would grab if I had to abandon my home - and the bulk of my preps - in a hurry (note: I have 2 rechargeable USB batteries and an MP3 player). It all fits in a tiny duffle bag that weighs less than 5lbs. 

For a bit more money you could go for a slightly bigger solar panel, additional USB battery banks, and maybe a personal MP3 player, walkie-talkies, and an emergency radio.  As the following photo illustrates, this type of modular system can be expanded over time.

The biggest downside to these types of setups is you are limited to USB (typically 5 volt) appliances. Fine for flashlights, phones, and MP3 players, but not nearly as versatile as a 12 volt system. 

For 12v/110v power, you could opt to buy a Jackery, Bluetti, EcoFlow, or similar `Solar Battery' setup, but it would set you back $400 -$1000+ (plus solar panel). And if it breaks, you don't have many options beyond sending it back for repair.

However, if you build your own - and keep a few spare parts on hand - you should be able to to keep it running yourself. (note: If you aren't comfortable working with these types of components, get help from someone who is). 

In 2024 I described building a rudimentary LiFePo4 power station (see picture below), which packed a decent 600 Watt/hour capacity. LiFePo4 batteries are lighter than lead/acid, are far less dangerous, and can be charged and discharged (fully) thousands of times.

My system featured dual 12V Car Cigarette Lighter Sockets (for CPAP, Electric cooler/fridge, or Inverter), 2 USB outlets, and I added a small 110v inverter. It is recharged by a 100 watt solar panel (shown on left). 

After my last hurricane I endeavored to improve my 12-volt battery bank (for build details, see Post-Milton Improvements To My Power Preps)

Weighing in at less than 15 lbs, this 50 amp/hr (600 watt/hour) setup is self contained, with storage for cables, a wall charger, and a small 110v inverter. All you need to add is a solar panel (100 watt or better).

The plastic carrying case was $12 at Harbor Freight, the 50 amp/hr battery was $109 on Amazon, and the rest of the build (solar charge controller, cables, lighted output panel, inverter) added about $60. 

All in, including taxes, this can be assembled in a couple of hours for less than $200.  I built a second, lighter weight and smaller version using a 20 amp/hr LiFePo4 battery (240 watt/hours) for less than $140. Something to keep on the bedside table.

Whether home built, or store bought, these `solar generators' can greatly expand what you can do during a prolonged blackout. They can recharge any USB item, run most 12 volt appliances, and some can power small 110 volt appliances for a short period of time. 

Even without the 110 volt output, which on small systems provides limited value, these setups can power a lot of useful items. 

Two years ago I purchased some very nice 4-packs of LED lanterns, and some USB battery powered water pumps that attach as a faucet to large water jugs. Just three days after they arrived I endured a 3-day water outage at home, and found the faucets actually worked pretty well.

Every home should have a battery operated radio (with NWS weather band), yet many do not. Some are available with crank or solar charging, but most have rechargeable batteries via a USB port.  



A 12 volt system (of sufficient size) can power a mini-fridge, or electric cooler,  and can not only keep food from spoiling, and drinks cold, it can keep medications like insulin cool.   

As for entertainment - which should not be discounted during a prolonged power outage - while a USB setup will power and charge a personal MP3 player, a 12 volt system can run a DVD player. 

As an aside - I've collected (public domain) OTR (Old Time Radio) shows since the early 1990s, and have literally thousands of hours stored on CDs in MP3 format. The Internet Archive has a huge repository where you can download them for free, along with thousands of audiobooks.

I keep a couple of MP3 players filled with these shows and with audiobooks in my bug-out bag. When the power and internet were down, they have provided me with hours of entertainment.

Over the years I've bought several cheap MP3 players ($20-$30) and filled them with thousands of hours of these shows (mostly from the 1940s and 1950s), giving them as gifts. And the nice thing is, you don't have to wait for an emergency to enjoy them.

Admittedly, since I lived happily for nearly 15 years aboard boats (2 sailboats, 1 power boat) here in Florida - where 12 volts ran just about everything - I may be a bit more amenable to the 12 volt life than others.  

But despite its obvious limitations, it sure beats cursing the darkness.  

EID Journal: Detection of HPAI A(H5N1) Virus in Cat and Rats during Outbreak in Backyard Poultry, United States, 2025

 

#19,340

Today we've a dispatch, published yesterday in the CDC's EID Journal, which describes the findings of HPAI H5N1 in a cat and a rat from an Illinois farm which experienced a bird flu outbreak in March of 2025.  

While it is not exactly `news' that both species are susceptible to H5N1 infection (see below), our understanding of how HPAI may spread among peridomestic animals on farms remains limited. 

EID Journal Dispatch: Seroprevalence of Influenza A(H5N1) Virus in Domestic Cats at Epicenter of Dairy Cattle Outbreaks, California, USA, 2024–2026

MMWR: Serologic Evidence of HPAI A(H5N1) Virus Infection in a Veterinary Professional Exposed to an Infected Domestic Cat

Experimental Infection of Rats with Influenza A Viruses: Implications for Murine Rodents in Influenza A Virus Ecology

Emer. Microbe & Inf.: HPAI Virus H5N1 clade 2.3.4.4b in Wild Rats in Egypt during 2023

CDC MMWR: HPAI H5N1 Virus Infection of Indoor Domestic Cats Within Dairy Industry Worker Households — Michigan, May 2024

The USDA's Detections of Highly Pathogenic Avian Influenza in Mammals dashboard lists more than 200 feline detections in the U.S. and a dozen H5N1 positive rats. Curiously, while I can find one entry of a cat from Bond County Illinois in March of 2025 (which may, or may not, refer to the cat in this study), there appear to be no reports of any rats infected in Illinois. 

According to this report, a farmer brought the remains of six animals (a chicken, a turkey, a goose, 2 Guinea fowl, and a rat (Rattus norvegicus)) to his veterinarian after nearly all of his chickens died. Suspecting H5N1, the vet sent the remains to the University of Missouri Veterinary Medical Diagnostic Laboratory (VMDL; Columbia, MO, USA) for postmortem examination.

VMDL ran a qRT-PCR on 1 chicken sample, which came back presumptive  positive for H5, and forwarded tissue samples to NVSL in Ames, IA for confirmatory testing (which verified HPAIV H5N1 clade 2.3.4.4b virus).

Four days after the first report, the local vet visited the farm and collected the remains of a 13-year-old cat and a second feral rat from the farm. They were then sent to the University of Illinois Veterinary Diagnostic Laboratory (VDL) for necropsy and additional testing. 

According to this report, state and local authorities were notified, and the Illinois Department of Agriculture and USDA quarantined the farm and monitored it for 4 months.

Today's report is primarily an analysis of the extensive infection of both the cat and the rat submitted to VDL. Sadly, while the first rat underwent necropsy, it was never tested for H5N1, so all we have is a sample of one.  

This seems like it was a great opportunity to explore the potential spread of HPAI among peridomestic animals on an infected poultry farm. But there is no indication that any attempts were made to collect and test additional samples. 

That said, this is a fascinating report that strongly suggests that an H5N1 farm outbreak should be viewed as a whole-premises event. Animals living around infected livestock - including cats and rats - may also be infected, and contribute to the evolution and further spread of the virus. 

Another finding of this dispatch is that all 3 animal species tested (cat, rat, and chicken) carried the PB2 E627K mutation which is generally considered a mammalian adaptation.  While not unheard of, reports of this mutation in birds are rare. 

Since only 1 chicken was tested, we've no idea of the frequency of this mutation in the rest of the flock.  

I've only posted the Abstract and some excerpts from the dispatch, so follow the link to read it in its entirety.  I'll have a postscript after the break.

Detection of Highly Pathogenic Avian Influenza A(H5N1) Virus in Cat and Rats during Outbreak in Backyard Poultry, United States, 2025

Suzanna M. Storms, Jade Rathmann, Lynette Hemker, Miranda Vieson, and Leyi Wang

Abstract

In 2025, highly pathogenic avian influenza A(H5N1) virus was detected in a poultry flock in Illinois, USA. Quantitative reverse transcription PCR, sequencing, and histopathology on cat and rat samples from the farm showed multiple positive tissues and high sequence identity to an avian isolate. Small mammals might contribute to H5N1 transmission.

The Study

On March 12, 2025, a farmer in southern Illinois with a small backyard poultry flock brought remains of 6 animals to their primary veterinarian for a necropsy workup after acute illness and near-complete mortality (100/105 birds) of the flock. The farm, ≈2 miles from a 25,000-acre reservoir lake within the Mississippi Flyway, housed 4 turkeys (Meleagris gallopavo), 1 goose (Anser sp.), 20 Guinea fowl (Numida spp.), 80 chickens (Gallus gallus domesticus), 17 cattle, 15 cats, and 2 dogs. Because HPAI virus (HPAIV) was suspected, the 6 animals, a chicken, a turkey, a goose, 2 Guinea fowl, and a rat (Rattus norvegicus), were sent to the University of Missouri Veterinary Medical Diagnostic Laboratory (VMDL; Columbia, MO, USA) for postmortem examination.

VMDL collected and evaluated fresh and formalin-fixed tissues and performed influenza A virus (IAV) quantitative reverse transcription PCR (qRT-PCR) on 1 chicken sample, according to guidelines from the US Department of Agriculture (USDA) National Animal Health Laboratory Network (NAHLN; https://www.aphis.usda.gov/labs/nahln). The sample tested presumptive positive per NAHLN guidelines, and VDML subtyped it as H5 influenza. VDML then forwarded the sample to the National Veterinary Services Laboratories (NVSL; Ames, IA, USA) for confirmatory testing, which verified HPAIV H5N1 clade 2.3.4.4b virus.

Further PCR testing of the avian species for Mycoplasma gallisepticum, M. synoviae, and avian paramyxovirus were all negative. The necropsy findings reported hepatitis, pulmonary hemorrhage, and pulmonary edema in the poultry species and bronchopneumonia and meningoencephalitis in the rat. No additional testing was performed on the rat or other bird species.

Upon report of HPAIV on the farm, state and federal agencies were notified. The Illinois Department of Agriculture and USDA quarantined the farm and monitored it for 4 months.

On March 16, 2025, the primary veterinarian collected the remains of a 13-year-old domestic shorthaired cat and a second feral rat from the farm. In conjunction with Illinois Department of Agriculture and USDA, the cat and rat specimens were sent to the University of Illinois Veterinary Diagnostic Laboratory (VDL; Urbana, IL, USA) on March 19. VDL performed gross necropsy and collected fresh and formalin-fixed tissues. VDL screened lung tissues from the cat and rat for IAV by qRT-PCR, following NAHLN guidelines. The cat lung tested presumptive positive (cycle threshold [Ct] value 21.2), subtyped as H5; NVSL confirmed H5N1 clade 2.3.4.4b virus. The rat lung tissue was negative upon initial screening, but NVSL conducted follow-up testing on tracheal swab samples, which were H5N1-positive.

Quantitative reverse transcription PCR results from HPAIV A(H5N1) in cat and rats during outbreak in backyard poultry, United States, 2025. Specimens obtained from a cat (A) and a rat (B) found dead on farm where the outbreak occurred were confirmed to be positive for H5N1 clade 2.3.4.4b, genotype D1.1 virus.

(SNIP)

Conclusions

We describe a strain of H5N1 that resulted in high mortality in a poultry flock and fatal illness in small mammals on a backyard farm in Illinois, USA. Our results show that extensive systemic H5N1 virus spread occurred in both cat and rat tissues after natural infection. Rat nasal turbinates and trachea preferentially expressed α2,3-linked sialic acid receptors relative to lung, likely explaining the lower Ct values in upper respiratory tissues and presence of bacterial bronchopneumonia, potentially leading to increased viral shedding (10).

Cat feces and urine have previously been shown to harbor H5N1 virus (11,12), which our results corroborate. Rats have previously been reported to harbor HPAIV in agricultural settings and have been detected in the current epizootic (13,14). Detection of HPAIV in rat urine and kidney tissue suggests that rodent urine could be a potential transmission medium and warrants further investigation.

Rats reside on many farms, can predate birds, and might serve as an intermediate step between infected avian species and susceptible mammalian hosts (15). That coexistence is particularly threatening for commercial poultry and swine confinement farms, which frequently harbor rodent populations despite strict biosecurity efforts. A limitation of our study was that no virus isolation was performed on tissues or urine due to biosafety constraints.

Although cats have been shown to participate in HPAIV transmission, our findings indicate that further investigation is needed to clarify the role of rodents. This study raises awareness of small mammals at the wildlife–livestock interface and highlights the potential role of rats in influenza transmission to commercial livestock production.

Dr. Storms is a veterinarian-scientist at Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, Texas, USA. Her research interests center around influenza virus transmission and diagnostic development.

Our continued reliance on passive surveillance severely limits our ability to understand the ecology and threat of HPAI H5. 

Because of the limited sampling on this farm, we can't say whether the PB2-E627K mutation was `fixed' in the poultry flock, or whether rat-to-rat transmission occurred, or whether any other species in and around the farm were affected. 

And we saw last year, in Nature: Lengthy Delays in H5N1 Genome Submissions to GISAID, the median delay in submitting sequences to GISAID was 7 months (228 days), with some countries taking nearly 2 years. 

Despite the mounting evidence of the susceptibility of cattle, sheep, goats, pigs, cats, and rats (ad nauseam) to HPAI H5 - and the continued calls from the scientific community for more aggressive surveillance and testing of livestock (see here, here, here, here, and here) - the world seems content to don blinders and hope for the best.

Sadly, the world continues to treat the spread of HPAI as more of an economic or political concern, than a public health threat. And while that optimistic assessment may be true today, there are no guarantees for tomorrow.