Showing posts with label case counts. Show all posts
Showing posts with label case counts. Show all posts

Sunday, March 29, 2015

More Than One Way to `Contain An Outbreak’

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Credit WHO

 

 

# 9879

 

Until the middle of January, Egypt’s Ministry of Health got good marks in reporting this winter’s surge in H5N1 cases, publishing frequent updates that included YTD numbers for cases, deaths, hospitalizations, and recoveries. 

 

That streak ended on January 22nd, when Egypt’s MOH Confirms their 21st H5N1 Case of 2015.

 

Since then, as has been noted often (see The Silence Of The Egyptian MOHMedia: WHO H5N1 Mission To Egypt), the Egyptian MOH has ceased to report most cases on their website and the YTD numbers attributed to MOH spokesmen in the Egyptian media have been `fanciful’ at best.


As a result, we continue to see reports like the one below – published today - which cherry picks a single recent H5N1 case, while at the same dramatically downsizing the YTD impact of this year’s H5N1 outbreak.  

 

While never directly mentioning 2015’s YTD numbers, by admitting to 16 deaths and referring to a CFR of 37.4%, the reader is left with the idea that there have been perhaps 43 or 44 cases this year.  

 

A far cry from the latest World Health Organization numbers (as of March 17th) of 116 cases and 36 deaths for the year (see Avian influenza A (H5N1) in Egypt update, 21 March 2015).

 

Egypt bird flu death toll at 16 in 2015

Sun, 29/03/2015 - 11:43

A 27-year old woman who raised birds in her home in the Sohag governorate, died of bird flu on Sunday.

Tahta Fevers Hospital received the victim, who was suffering from bird flu symptoms, before she was transferred to Assiut Fevers Hospital upon the request of her family, according to a medical source at Tahta hospital.

A medical team inspected the woman's house in Tahta and conducted tests on those who were in contact with the woman as a preventive measure.

(Continue . . .)

Although local media reports are sporadic, and are unlikely to represent the true burden of this year’s outbreak,  FluTracker’s conservatively curated Egypt - 2015 WHO/MoH/Provincial Health Depts H5N1 Confirmed Case List  continues to add cases, with at least 120 cases logged for the year.


Fortunately,  Egypt continues to report cases to the World Health Organization under the IHR (International Health Regulations) - which requires countries to develop mandated surveillance and testing systems, and to report certain disease outbreaks and public health events to WHO – so we are not completely in the dark regarding this H5N1 outbreak.

 

While we don’t have a recent WHO update to compare it to, China’s recent silence on H7N9 is also suspect, with no new cases reported now for 20 days (see last week’s HK CHP Avian Flu Report: 2 Weeks Without An H7N9 Case Report and  H7N9: No News Is . . . . Curious).  

 

This dramatic halt in reporting comes – perhaps coincidentally – at the same time we saw a major study appear in the Journal Nature  (see Dissemination, Divergence & Establishment of H7N9 In China) warning that the H7N9 virus was evolving rapidly, and that it posed a growing pandemic threat.


A search on Xinhua’s English language news site for the term `H7N9’ returns their last article on March 12th of this year, which (again, perhaps coincidentally) dealt with the Nature study above (see Scientists call for effective measures amid H7N9 mutation Xinhuanet 2015-03-12 14:13).

 

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The Chinese language IFENG search engine does return more recent `H7N9’ articles, but they all refer to cases in February and/or steps local and national health officials are taking to prevent new cases.  

 

But if there have been any H7N9 cases detected since early March, they aren’t being reported in the media, or on provincial MOH websites.

 

It is certainly possible that fewer infections are being recorded this winter, and interventions such as the closing of live poultry markets have dramatically reduced transmission.  That all cases should halt abruptly, this early in the year, and across the entire region would be remarkable, however. 


We’ll have more to go on when the next WHO update on China is released.

 

Since China and Egypt are both dealing with high-profile infectious disease outbreaks, their `management’ of the news understandably draws a good deal of attention, but they are far from being the only nations who indulge in `creative disease reporting’.  

 

All governments have an aversion to mobs bearing pitchforks and torches, and therefore want to project the image that they are competent, in control, and (most importantly) vitally important to the people they supposedly serve. 

 

Even in this country I see a number of state and local health and agricultural department websites which seem far more concerned with extolling their services and achievements, than they are in addressing local problems.  Of course, none of them are dealing with a deadly avian flu outbreak, so direct comparisons are hard to make.

 

While it may seem an odd bit of logic, as long as governments can control the message - as we are seeing in Egypt – it is a pretty good sign that avian flu infections remain sporadic and that efficient transmission of the virus is not happening.   

 

So, in a sense, no news can be `good news’ – at least in the short run. 

 

The problem is, the less we know about the early trajectory of an outbreak, the less lead time we’ll have to prepare - if and when something does start to change.

Wednesday, March 11, 2015

WHO: Updated H5N1 Cumulative Case Count Table

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Excerpted from WHO Case Count Table – March 3rd

 

# 9808

 

In yesterday’s WHO H5N1 Update – Egypt I mentioned that the latest cumulative H5N1 human case count table had not yet been uploaded, although based on the summary narrative it appeared that we’ve had `roughly * 88 cases, and 24 deaths’  reported in Egypt since the first of the year.


Overnight a new chart has been published, and in it we find a slight adjustment to the 2014 numbers (10 deaths reduced from 11 in the last report), and a YTD total of 88 cases, and 26 deaths.

 

Since this outbreak began in November, Egypt has reported 115 cases and 36 fatalities, making this the largest single nation run of cases since the virus began is main assault in 2003.

image

 

Based on the reporting cut-off of March 3rd, delays in the Egyptian MOH forwarding reports to the WHO, and the sporadic reporting of new (suspected & confirmed) cases in the media, it is safe to assume these numbers continue to expand.

 

Unknown, too, are how many mild or moderate infections there might be that are never counted.  

 

While the assumption is that some number of H5N1 cases go undiagnosed (or are misdiagnosed), and only the `sickest of the sick’ seek medical treatment and are counted, so far the evidence for there being a lot of missed  `mild’ cases is fairly limited. 

 

In PLoS One: Seroprevalence Of H5N1 Among Bangladeshi Poultry Workers, we looked at the paucity of evidence for missed cases, and ongoing debate over the actual burden of the disease, and the resultant CFR (Case Fatality Rate). 

 

Currently the WHO, FAO, NAMRU-3 and other International agencies are in Egypt reviewing the situation and offering advice to the Egyptian government on controlling this outbreak. 

 

We hope to get some sense of their findings in the next couple of days.


Stay tuned.

Wednesday, April 23, 2014

The Fog Of MERS

surveillance

Credit CDC

 

# 8517

 

We are now two years into the MERS outbreak on the Arabian Peninsula, with roughly 350 human infections announced to date. Of those, nearly 30%  have been reported over the past month.  A spike in case reports that has many scientists wondering if the virus is better adapting to human hosts (see Osterholm On NPR Shots).

 

Given limited (and sometimes, totally absent) surveillance for the virus in the Middle East and the wide variability of illness it produces in humans (from asymptomatic to severe, or even fatal), the actual number of infections is undoubtedly much higher.

 

As with any disease, we usually only see the tip of the pyramid, and must rely on various tools (like seroprevalence studies) to estimate the true burden.   Tools that have yet to be well utilized in this MERS outbreak.


Although no surveillance system can expect to capture all of the cases, keeping epidemiological line listings remains an important tool.  It can show trends, geospatial clustering, epidemiological links between cases, and can suggest the rate at which an infection is spreading. 

 

Even under the best of conditions maintaining a line listing is a difficult job, but in the case of MERS, far too often the case data announced by the Ministries of Health in the region have either been delayed or have not contained the kind of information (onset dates, previous contacts, date of lab confirmation, etc.) that would be particularly useful.

 

Compared to the H7N9 information we’ve seen coming from the Chinese Authorities, the quality of data on MERS cases has been very uneven and disappointing.

 

Despite the difficulties involved, Sharon Sanders and the newshounds on FluTrackers have been maintaining an extensive 2012-2014 Case List of MoH/WHO Novel Coronavirus nCoV Announced Cases for the past 15 months. Case are linked to the MOH or WHO announcements, and are updated (when possible) with outcomes.  Cases are also grouped by `cluster’ and by country.

 

Almost from the beginning, however, it was apparent that there were `gaps’ in the reporting of cases out of the Middle East, and so Sharon posted the following announcement at the top of the list nearly a year ago.

image

 

As the number of cases has grown rapidly over the past month, we’ve seen some `blind’ announcements coming from various MOH’s, where batches of  `new cases’ are announced without any identifying details (age, gender, location, etc.).

 

When cases are eventually reported to the World Health Organization and posted on their Global Alert & Response webpage, there is no way to link those cases with earlier `blind’ reports.

 

Although the number of these `unable to match’ cases is small right now, keeping any sort of `count’ of cases grows more difficult with each passing day.  `Creeping errors’ are inevitable, and so today Sharon Sanders (who deserves the `Dogged Determination Award’ for curating this list for well over a year) made the following announcement on her list.

 

PLEASE NOTE: Due to apparent redundant case reporting, we are no longer tracking case totals. April 23, 2014

 

FluTrackers will continue to accrue and post cases, and that information will continue to be incredibly useful to bloggers, journalists, and researchers.  But there are limits as to what can be done when data is released haphazardly, or without adequate detail, by health ministries.

 

As to whether this signals a new, more serious `phase’ in the MERS outbreak  . . .  well, it is possible.

 

Unfortunately, the outside world isn’t being given enough information to make that determination.

Friday, February 21, 2014

H7N9 Moves North, Guangdong Reports New Cases

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Dr. Ian Mackay’s latest H7N9 Hotspot Map adds Jilin province

 

# 8320

 

Dr. Ian Mackay has already blogged the story, and updated his map this morning, on the most northern report of H7N9 to date in China – that of a 50 year-old male poultry farmer from Jilin  Province who is reportedly isolated and in stable condition. 

 

It is worth noting that Jilin province lies adjacent to North Korea, a closed society that rarely reports on any public health situations.

 

While there are a number of media reports on this case (see FluTrackers thread here), thus far I’ve not found any official statement from the Jilin Provincial authorities. The following (machine translated) report comes from Xinhua News.

 

Jilin confirmed its first case of human infection with the H7N9 avian flu

At 20:04 on February 21, 2014
Source:
Legal Network

0 People involved 0 Comment

Xinhua Changchun February 21 (Reporter Yao Youming) 21, the Jilin Provincial Government Information Office announced that the H7N9 bird flu found in Changchun City's first confirmed case of human infection, which is also confirmed cases of H7N9 bird flu first case of human infection in Jilin .

It is understood that the patient was a 50-year-old man surnamed Liang, currently residing in net Development Zone in Changchun, poultry farming, currently implemented in the hospital for isolation and treatment, the condition is more stable. After investigation of the epidemiological investigation of close contacts of patients have been implemented under medical observation, did not reveal any abnormalities.

Jilin Provincial Government Information Office official microblogging "Jilin release," said the Changchun City CDC received reports of 19 May, the First Hospital of Jilin University, admitted to a pneumonia patient with history of exposure to dead poultry. Changchun City CDC immediately organize relevant personnel to carry out epidemiological surveys and collect patient specimens for testing, the results of human infection of H7N9 avian influenza virus positive by the Jilin Provincial CDC complex, the results are positive. 21 am Chinese CDC review the results as positive feedback.

Jilin Provincial Government has launched the emergency response. Changchun City is fully deployed to implement the emergency response and control measures.

 


Additionally, Shiloh on FluTrackers has picked up the report of three more H7N9 cases from Guangdong province.

 

Guangdong Province reported three new cases of human infection with H7N9 bird flu virus


2014-02-21 14:01:48 / Ministry of Health and Family Planning Commission

Health and Family Planning Commission of Guangdong Province on February 21 briefing, Guangzhou, Zhaoqing, Jiangmen City 3 3 new cases of human infection of H7N9 avian influenza confirmed cases.

The first case is a female, 46 years old, currently residing in Zhaoqing Sihui. Confirmed on February 19, currently treated in a hospital.

The second case is a male, 64 years old, currently residing in Haizhu District of Guangzhou. Died on February 18. Retrospectively confirmed on February 19.

The third case is a male, 69 years old, currently residing in Jiangmen, Kaiping City. Confirmed on February 20, currently treated at a local hospital.

An earlier Shenzhen case, confirmed on January 30, one in Tangmou and one in Zhaoqing City, confirmed on February 7, recovered.

 

Sharon Sanders on Flutrackers has already added these four cases to her terrific H7N9 Case Line List, without which I’d never be able to keep these cases straight.

#362 - Woman, 46, Zhaoqing Sihui. Confirmed on February 19, currently treated in a hospital. Guangdong province


#363 - Man, 64, Haizhu District of Guangzhou. Died on February 18. Retrospectively confirmed on February 19. Guangdong province Death


#364 - Man, 69, Jiangmen, Kaiping City. Confirmed on February 20, currently treated at a local hospital. Guangdong province


#365 - Man, 50, engaged in poultry farming. Currently treated in isolation at hospital, in stable condition, hospitalized on Feb 19, confirmed on Feb 21. Jilin Province
 

 

One of the remarkable things about this ad hoc collective we call Flublogia is that there is almost always a volunteer on watch somewhere in the world, 24 hours a day.  While I’m sleeping I know that Crof on the West Coast of Canada is up, and blogging, and that 16 time zones ahead of me, Dr. Ian Mackay is keeping a watchful eye from Australia.

 

Similarly, newshounds like Ironorehopper  and Tetano in Italy,  Gert van der Hoek in The Netherlands, Biological in Ireland (and others, too numerous to mention) are on watch around the globe, posting their finds on FluTrackers and the Flu Wiki (for more on this, see Newshounds: They Cover The Pandemic Front).

 

Lest anyone think that this blog is a solitary endeavor, much of what appears here on AFD would be impossible were it not for their hard work and generous support.

Thursday, February 20, 2014

WHO On H7N9 Case Counts & Fatalities

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# 8318

 

A follow up to my earlier report on China’s Ministry of Agriculture’s H7N9 cases counts and fatalities (see China’s MOA: H7N9 Fatalities Higher Than Previously Announced) comes courtesy of sharp-eyed Lisa Schnirring at CIDRAP NEWS who spotted what I read right past this morning in the WHO’s Recommended Composition Of 2014-15 Northern Hemisphere Flu Vaccine report.

 

Embedded halfway down  the second page is a brief synopsis with an even higher H7N9 fatality count (112 vs. 109)  than we saw announced earlier today from the China’s MOA, although with an increase in the number of overall cases (355 vs. 347) the resultant CFR (Case Fatality Ratio) is only marginally higher.

 

Zoonotic influenza infections caused by A(H5N1), A(H7N9), A(H9N2) and A(H10N8) viruses


From 24 September 2013 to 17 February 2014, 15 confirmed human cases of A(H5N1), 9 of which were fatal, were reported from Cambodia, Canada, China, Indonesia and Viet Nam. Highly pathogenic avian influenza A(H5N1) is present in poultry in each of  these countries except Canada. Since December 2003, a total of 652 cases with 387 deaths have been confirmed in 16 countries. To date there has been no evidence of sustained human-to-human transmission.

During this period 220  additional  human  cases of avian influenza A(H7N9) virus infection have been reported. All cases were in China with the exception of a single case detected in Malaysia in an individual travelling from Guangdong Province, China. Since February 2013, a total of 355 cases with 112 deaths have been reported3

Two cases of A(H9N2) were reported in this period, one each in China,  and China Hong Kong Special Administrative Region. The associated disease in both cases was mild with both viruses belonging to the A/chicken/Hong Kong/Y280/97 genetic lineage.

Three cases of A(H10N8) with two deaths were reported from Jiangxi Province, China during this period.  

 

While these numbers are not an exact match (likely due to different report cutoff dates), this is a very useful confirmation of the Chinese MOA report from earlier today, which indicated a mortality rate of over 31% among known cases. 

 

There are, almost certainly, some unknown number of  mild or asymptomatic cases not being counted. So this doesn’t tell us the absolute CFR (case fatality ratio) of this infection, only the current mortality rate among patients ill enough to be hospitalized.

 

Given that there are a number of already counted cases that are currently hospitalized, but whose outcome is not yet known, it is also possible this ratio could go higher.

 

What we don’t seem to have at this point is a sense of whether this mortality rate has remained more-or-less constant since the outbreak began a year ago, or if it has increased during this second wave.

 

For now, despite the high mortality rate of this virus, the good news is that it hasn’t shown the ability to transmit efficiently between humans.  But, like all influenza viruses, what we can say about it today may not hold true next week, or next year.

Saturday, February 15, 2014

Guangdong, Anhui & Hunan Provinces Report H7N9 Cases

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Dr. Ian Mackay’s latest Snapdate Chart


# 8302

 


While the number of new H7N9 cases announced out of China continues to run at a slower pace than a week ago (see Ian Mackay’s VDU Blog for a discussion of possible reasons),  we have 4 new cases annouced so far today.

 

Over the past two days Guangdong Province has reported 4 H7N9 cases (2 yesterday, 2 today), including a pediatric (age=4) reportedly in stable condition.

 

Province 2 new confirmed cases of human infection with H7N9 avian influenza

2014-02-14 15:08:13 Ministry of Health and Family Planning Commission

Health and Family Planning Commission of Guangdong Province on February 14 Bulletin, Guangzhou, Jiangmen City added two cases of human infection with H7N9 avian influenza confirmed cases.


Case 1 Lee, M, 78 years old, retired people, now living in Panyu District, Guangzhou City, suffering from chronic obstructive pulmonary disease more than a decade, February 13 confirmed cases of human infection of H7N9 avian influenza, He died on February 14 date of death.


Case 2 Easy A, F, 66 years old, domestic unemployment, currently residing in Heshan, Jiangmen, February 13 confirmed cases of human infection of H7N9 avian influenza, the patient is currently in critical condition, were treated at a local hospital sentinel.

 

Province 2 new confirmed cases of human infection with H7N9 avian influenza

2014-02-15 09:47:25 Ministry of Health and Family Planning Commission

 Health and Family Planning Commission of Guangdong Province on February 15 briefing, the Guangzhou new confirmed cases of H7N9 avian flu two cases of human infection.

Case 1 Zhou, female, 4 years old, currently residing in Baiyun District, Guangzhou City, February 14 confirmed cases of human infection of H7N9 avian influenza, the patient's condition is currently stable, the designated hospital in Guangzhou hospital.

Case 2 Wei, male, 79 years old, farmer, now living in Panyu District, Guangzhou City, February 14 confirmed cases of human infection of H7N9 avian influenza, the patient is currently in critical condition in hospital in Guangzhou Hospital Wards.


Also, Zhaoqing City, February 8 cases diagnosed LiangMou cured.

 

Anhui Province – which up until 5 days ago hadn’t reported any cases in this second wave – now reports its 3rd case in less than a week.

 

Province added one case of human infection of bird flu H7N9

Published :2014-02-15 Source: The Read 970 times

Anhui Provincial Health Department on February 15 briefing, the province confirmed one case of human infection with the H7N9 avian influenza.

Patients Jo, female, 14 years old, Huaining County, February 14 was infected with H7N9 bird flu confirmed human cases of the disease are now stable in Anqing City hospitals for treatment.

 

Our last stop is Hunan province, which also reports a single new case.

 

Hunan Province 1 new confirmed cases of human infection with H7N9 avian influenza

Time :2014-02-15 Author:

February 15, Hunan 1 new confirmed cases of human infection with H7N9 avian influenza, as the province 10 confirmed cases. Case Yan Moumou, male, 46 years old, who lives in Loudi Lianyuan. Currently the patient is in a hospital for treatment of Loudi. (Contributed by: Office of Emergency Management Office)

 

 

Flutrackers has added these six cases to their  H7N9 Line Listing.

 

#348 - Man, 78, retired, Panyu District, Guangzhou City, suffering from chronic obstructive pulmonary disease more than a decade, confirmed on February 13, died on February 14. Guangdong province Death


#349 - Woman, 66, domestic unemployment, Heshan, Jiangmen, confirmed on February 13, currently in critical condition, treated at a local hospital sentinel. Guangdong province


#350 - Girl, 4, Baiyun District, Guangzhou City, confirmed on February 14, currently in stable condition in the designated hospital in Guangzhou. Guangdong province


#351 - Man, 79, farmer, Panyu District, Guangzhou City, confirmed on February 14, currently in critical condition in hospital in a Guangzhou Hospital Wards. Guangdong province


#352 - Girl, 14, Huaining County, Anqing City, confirmed on February 14, now in stable condition in an Anqing City hospitals for treatment. Anhui province


#353 - Man, 46, hospitalized, confirmed on February 15, Loudi Lianyuan Hunan province

Guangdong, Anhui & Hunan Provinces Report H7N9 Cases

image

Dr. Ian Mackay’s latest Snapdate Chart


# 8302

 


While the number of new H7N9 cases announced out of China continues to run at a slower pace than a week ago (see Ian Mackay’s VDU Blog for a discussion of possible reasons),  we have 4 new cases annouced so far today.

 

Over the past two days Guangdong Province has reported 4 H7N9 cases (2 yesterday, 2 today), including a pediatric (age=4) reportedly in stable condition.

 

Province 2 new confirmed cases of human infection with H7N9 avian influenza

2014-02-14 15:08:13 Ministry of Health and Family Planning Commission

Health and Family Planning Commission of Guangdong Province on February 14 Bulletin, Guangzhou, Jiangmen City added two cases of human infection with H7N9 avian influenza confirmed cases.


Case 1 Lee, M, 78 years old, retired people, now living in Panyu District, Guangzhou City, suffering from chronic obstructive pulmonary disease more than a decade, February 13 confirmed cases of human infection of H7N9 avian influenza, He died on February 14 date of death.


Case 2 Easy A, F, 66 years old, domestic unemployment, currently residing in Heshan, Jiangmen, February 13 confirmed cases of human infection of H7N9 avian influenza, the patient is currently in critical condition, were treated at a local hospital sentinel.

 

Province 2 new confirmed cases of human infection with H7N9 avian influenza

2014-02-15 09:47:25 Ministry of Health and Family Planning Commission

 Health and Family Planning Commission of Guangdong Province on February 15 briefing, the Guangzhou new confirmed cases of H7N9 avian flu two cases of human infection.

Case 1 Zhou, female, 4 years old, currently residing in Baiyun District, Guangzhou City, February 14 confirmed cases of human infection of H7N9 avian influenza, the patient's condition is currently stable, the designated hospital in Guangzhou hospital.

Case 2 Wei, male, 79 years old, farmer, now living in Panyu District, Guangzhou City, February 14 confirmed cases of human infection of H7N9 avian influenza, the patient is currently in critical condition in hospital in Guangzhou Hospital Wards.


Also, Zhaoqing City, February 8 cases diagnosed LiangMou cured.

 

Anhui Province – which up until 5 days ago hadn’t reported any cases in this second wave – now reports its 3rd case in less than a week.

 

Province added one case of human infection of bird flu H7N9

Published :2014-02-15 Source: The Read 970 times

Anhui Provincial Health Department on February 15 briefing, the province confirmed one case of human infection with the H7N9 avian influenza.

Patients Jo, female, 14 years old, Huaining County, February 14 was infected with H7N9 bird flu confirmed human cases of the disease are now stable in Anqing City hospitals for treatment.

 

Our last stop is Hunan province, which also reports a single new case.

 

Hunan Province 1 new confirmed cases of human infection with H7N9 avian influenza

Time :2014-02-15 Author:

February 15, Hunan 1 new confirmed cases of human infection with H7N9 avian influenza, as the province 10 confirmed cases. Case Yan Moumou, male, 46 years old, who lives in Loudi Lianyuan. Currently the patient is in a hospital for treatment of Loudi. (Contributed by: Office of Emergency Management Office)

 

 

Flutrackers has added these six cases to their  H7N9 Line Listing.

 

#348 - Man, 78, retired, Panyu District, Guangzhou City, suffering from chronic obstructive pulmonary disease more than a decade, confirmed on February 13, died on February 14. Guangdong province Death


#349 - Woman, 66, domestic unemployment, Heshan, Jiangmen, confirmed on February 13, currently in critical condition, treated at a local hospital sentinel. Guangdong province


#350 - Girl, 4, Baiyun District, Guangzhou City, confirmed on February 14, currently in stable condition in the designated hospital in Guangzhou. Guangdong province


#351 - Man, 79, farmer, Panyu District, Guangzhou City, confirmed on February 14, currently in critical condition in hospital in a Guangzhou Hospital Wards. Guangdong province


#352 - Girl, 14, Huaining County, Anqing City, confirmed on February 14, now in stable condition in an Anqing City hospitals for treatment. Anhui province


#353 - Man, 46, hospitalized, confirmed on February 15, Loudi Lianyuan Hunan province

Dr. Mackay On H7N9 Market Closures & Case Reporting Out Of China

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# 8301

 

Over night Dr. Ian Mackay on his VDU blog has been busy, posting a pair of blogs on the (apparent) effects of market closures in China on the spread of H7N9, and other possible reasons behind the recent drop in case reports. 

 

In the second blog listed, he articulates some of the concerns that many flu watchers have over the recent decline in reporting out of China.


Follow the links to read:

 

Zhejiang province leads the way in H7N9 cases and their decline 3-weeks after market closures...

Click on image to enlarge.

It's the Province in China that has seen more H7N9 cases confirmed in human than any other Province (39% of all cases have originated here).

It reached 50 cases faster in 2014 than 2013.

It closed its markets back in 24-Jan. And for a little while it kept finding new cases.

But the past 2-days have see no new cases announced from Zhejiang province. Eerily reminiscent of 2013 sudden disappearance of cases announcements.

(Continue . . .)

 

 

H7N9 case announcements dropping: is Wave 2 under control? [UPDATED]

Its a very tough question to answer. There has been public pressure by China's poultry-farming groups on China to take measures to stem the industry's financial losses. These have been driven by the public concern that H7N9 can seriously afflict people and in about a fifth of recorded instances, kill them.

(Continue . . .)

Wednesday, February 12, 2014

H7N9 Case Reports From China

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Credit CDC

 

# 8292

 


In addition to the two imported cases reported earlier this morning by Hong Kong and Malaysia (see here, and here), we’ve reports from Guangdong, Zhejiang, and Hunan provinces in Mainland China totaling 7 new cases. 

 

Although it is late evening in China, it is always possible we could see additional cases announced later in the day.


Our first stop,  Guangdong Province, which reports three new cases.

 

Province 3 new confirmed cases of human infection with H7N9 avian influenza

2014-02-12 14:26:37 Ministry of Health and Family Planning Commission

Health and Family Planning Commission of Guangdong Province on February 12 Bulletin, Guangzhou, Zhaoqing City new confirmed cases of H7N9 avian influenza three cases of human infection.

Case 1 Hwang, male, 8 years old, student, now living Huaiji County, Zhaoqing City, February 11 confirmed cases of human infection of H7N9 avian influenza, the patient's condition is currently stable, treated at a local hospital sentinel.

Case 2 Yijun, male, 46 years old, farmer, now living in Nansha District, Guangzhou City, February 11 confirmed cases of human infection of H7N9 avian influenza, the patient is currently in critical condition in hospital in Guangzhou Hospital Wards.

Case 3 Zhou, male, 65 years old, farmer, now living Baiyun District, Guangzhou City, February 11 confirmed cases of human infection of H7N9 avian influenza, the patient is currently in critical condition in hospital in Guangzhou Hospital Wards.

Also, Zhaoqing City, February 1 confirmed case of certain European and February 5, Lee confirmed cases were cured.

 

Zhejiang Province, which has recorded more than 1/3rd of all cases on the Mainland, also reports 3 new cases.

 

Zhejiang Province, three new cases of human infection of bird flu H7N9

Zhejiang Provincial Health and Family Planning Commission Feb. 12 briefing, the province added three cases of human infection with the H7N9 avian influenza.

1, patients Jin Moumou, male, 84 years old, farmer, Wu Jinhua city people. February 11 confirmed human cases of avian influenza H7N9 infection. Is now in critical condition, a hospital for treatment in Jinhua.

2, patients Moumou, male, 58 years old, farmer, Xiaoshan District, Hangzhou people. February 11 confirmed human cases of avian influenza H7N9 infection. Now the condition is severe, treatment in a hospital in Hangzhou.

3, Shen certain patients, male, 46 years old, farmer, Yuhang District of Hangzhou people. February 11 confirmed human cases of avian influenza H7N9 infection. Now the condition is severe, treatment in a hospital in Hangzhou.

 

And lastly, Hunan province a single case.

 

Hunan Province 1 new confirmed cases of human infection with H7N9 avian influenza

Time :2014 -02-12 Author:

February 12, Hunan 1 new confirmed cases of human infection with H7N9 avian influenza, as the province ninth confirmed cases. Case Shao Moumou, male, 19 years old, who lives in Loudi Lianyuan. Currently the patient is in a hospital for treatment of Loudi. (Contributed by: Office of Emergency Management Office)

 

 

Sharon Sanders at FluTrackers has already updated their H7N9 Line listing, and continues to do a terrific job keeping track of these cases.  Clicking on the case # will take you to the original case report.

 

#339 - Boy, 8, Huaiji County, Zhaoqing City, confirmed on February 11, currently in stable condition, treated at a local hospital sentinel. Guangdong province

#340 - Man, 46, farmer, Nansha District, Guangzhou City, confirmed on February 11, currently in critical condition in hospital in a Guangzhou Hospital Wards. Guangdong province

#341 - Man, 65, farmer, Baiyun District, Guangzhou City, confirmed on February 11, currently in critical condition in a hospital in Guangzhou Hospital Wards. Guangdong province

#342 - Man, 84, farmer, Wu Jinhua city. Confirmed on Feb. 11, now in critical condition in a hospital for treatment in Jinhua. Zhejiang province

#343 - Man, 58, farmer, Xiaoshan District, Hangzhou. Confirmed on Feb. 11, in serious condition, treatment in a hospital in Hangzhou. Zhejiang province

#344 - Man, 46, farmer, Yuhang District of Hangzhou. Confirmed on Feb. 11, in serious condition, treatment in a hospital in Hangzhou. Zhejiang province

#345 - Man, 19, Loudi Lianyuan. Currently the patient is in a hospital for treatment of Loudi. Hunan province

#346 - Woman, 67, onset January 30 in Guangdong China, hospitalized February 7 in stable condition in Malaysia

#347 - Man, onset February 8, hospitalized February 11 in Hong Kong - recent travel history to Kaiping, Guangdong

 

All totaled, we’ve added 9 cases to the case list today.

Monday, February 10, 2014

Zhejiang, Guangdong, Hunan & Anhui Provinces Report H7N9 Cases

image

Credit CDC

 

*** UPDATED ***

Less than 1 minute after I posted this blog, Ironorehopper tweeted a new case from Hunan Province.

Hunan Province, one case of human infection with the H7N9 new bird flu cases

Time :2014-02-10 Author:

2 Month 10 Day, Hunan New 1 Cases of human infection H7N9 Confirmed cases of bird flu, the first for the province 8 Confirmed cases. Ryu cases, male, 23 Year-old, who lives in Loudi Shuangfeng is currently in a hospital in Changsha treatment. (Contributed by: Office of Emergency Management Office)


# 8284

 

Our daily tally of new H7N9 cases includes reports from three four provinces, starting with Zhejiang.

 

Zhejiang Province, three new cases of human infection of bird flu H7N9

Source: Ministry of Health and Family Planning Commission

February 10, 2014

Zhejiang Provincial Health and Family Planning Commission Feb. 10 briefing, the province added three cases of human infection with the H7N9 avian influenza.

In certain patients, male, 67 years old, Jiaxing, Haining people, February 10 confirmed cases of human infection of H7N9 avian influenza. Is now in critical condition at a hospital in Hangzhou treatment.

Patients Liu XX, female, 47 years old, Wenzhou Yueqing City People, February 10 confirmed cases of human infection of H7N9 avian influenza. Now the condition is severe, treatment in a hospital in Hangzhou.

Patients Lv Moumou, male, 62 years old, Lishui Jinyun County, February 10 confirmed human infection of H7N9 avian influenza. Is now in critical condition at a hospital in Lishui treatment.


Guangdong province meanwhile only reports 1 new case.

 

Province 1 new confirmed cases of human infection with H7N9 avian influenza

2014-02-10 15:26:27 Ministry of Health and Family Planning Commission

Health and Family Planning Commission of Guangdong Province on February 10 briefing, the Guangzhou new confirmed cases of H7N9 avian influenza case of human infection.


Luomou cases, female, 5 years old, currently residing in Baiyun District, Guangzhou City, February 8 confirmed cases of human infection of H7N9 avian influenza, patients with mild symptoms have been cured.

 

And, as I reported earlier, Anhui Province Reports 2nd H7N9 Case Of 2014.

 

Flutrackers has added these five cases to their (awesome) H7N9 Line Listing.

 

#332 - Man, 56, Linquan county, confirmed on February 9, died on February 7. Fuyang city - Anhui Death


#333 - Man, 67, Jiaxing, Haining, confirmed on February 10, now in critical condition, in a Hangzhou hospital for treatment. Zhejiang province


#334 - Woman, 47, Wenzhou Yueqing, confirmed on February 10, in severe condition, treatment in a hospital in Hangzhou. Zhejiang province


#335 - Man, 62, Lishui Jinyun County, confirmed on February 10,now in critical condition in a hospital in Lishui treatment. Zhejiang province


#336 - Girl, 5, Baiyun District, Guangzhou City, confirmed on February 8, with mild symptoms, recovered. Guangdong province

 

 

As a final note, there’s a news report wending its way through the Chinese and English Language press today regarding an `imported’ case of H7N9 into China, from Hong Kong.   I believe this is a case we covered 10 days ago, but here is the Xinhua report:

 

China reports first incoming tourist H7N9 case

Feb 10,2014

BEIJING, Feb. 10 (Xinhua) -- A boy entering the Chinese mainland from the Hong Kong Special Administrative Region has been confirmed as infected with H7N9 bird flu, China's quarantine authority said on Monday.

 

Infection of the six-year-old boy, found in the city of Shenzhen across the border from Hong Kong, marks the first human H7N9 case for tourists entering the Chinese mainland, said the General Administration of Quality Supervision, Inspection and Quarantine.

 

The case was first noted on Jan. 28 when the boy was diagnosed with a fever of 38.2 degrees Celsius and other symptoms such as a red throat and swelling tonsils, and confirmed later by the quarantine authorities and disease control center of Guangdong Province.

 

China has reported more than 120 human H7N9 cases this year, including over 26 deaths, with the provinces of Zhejiang and Guangdong worst affected.


Which looks remarkably like the case reported by the World Health Organization on February 3rd.

 

A 6-year-old boy who is living in Shenzhen City, Guangdong Province, and became ill on 27 January. He was detected on 28 January by Shenzhen Entry-Exit Quarantine Bureau when travelling through Huanggang Port. He has mild symptoms and is in a stable condition. He is currently in isolated treatment at home. The patient has a history of exposure to live poultry.

 

The Xinhua report calls it an `incoming case’ – intimating, I guess, that the boy acquired the infection in Hong Kong.

 

As I’ve not seen any details on how long the boy had been away from his home in Shenzhen (hours? days?), I’m unable to even guess where the boy might have been infected.  If Hong Kong’s CHP posts an update on this case, I’ll mention it.

Sunday, February 09, 2014

Zhejiang, Jiangsu, Guangdong, Hunan & Anhui Report Weekend H7N9 Cases

image

Credit CDC

 


# 8280

 

With the twin caveats that reporting during the weekend may not be as robust as during the week, and substantial pressure has been placed on the provinces to curb their reporting of cases (see Sandman & Lanard On China’s H7N9 Risk Communications), H7N9 case reports have dropped by roughly 50% over the past two days – although it is too soon to call it a trend.

 

The following 7 cases have been added to FluTrackers  H7N9 Case Line Listing over the past 48 hours, with 2 cases from Zhejiang, 2 from Guangdong, and one each from Anhui, Jiangsu, and Hunan provinces.

 

#325 - Man, 61, Xiaoshan District, Hangzhou, confirmed on Feb. 7, now in critical condition in a Hangzhou a hospital for treatment. Zhejiang province


#326 - Man, 38, Suining County of Shaoyang City. Hunan province


#327 - Man, 53, confirmed on February 8 pm, exposoure to diseased poultry, currently in a hospital for treatment of Taizhou, serious condition - Jiangsu province


#328 - Man, 66, Susong County, confirmed on February 8, now in a Anqing City Hospital for treatment. Anhui


#329 - Woman, 81, Luohu District, Shenzhen, confirmed on February 8, died on February 7. Guangdong province Death


#330 - Boy, 11, student, Huaiji County, Zhaoqing City, confirmed on February 8, currently in stable condition, treated at a local hospital sentinel. Guangdong province


#331 - Man, 68, Shaoxing Bridge District, confirmed on February 9, in severe condition, in a Shaoxing hospital for treatment. Zhejiang province

 

Of note, the 66 year-old from Susong county is the first reported case from Anhui province during this second wave, raising that province’s total to just 5 cases.  

image

Credit ECDC - Distribution of confirmed A(H7N9) cases by place of reporting, week 08/2013 to 06/2014, China (n=308)

 

After reporting scattered cases last spring, thus far Jiangxi, Henan, Shandong, and Hubei provinces have yet to report new cases during this second wave.

Thursday, February 06, 2014

Beijing & Four Provinces Report New H7N9 Cases

image

Credit CDC

 

 

# 8274

 

Our daily perusal of H7N9 cases takes us to four Chinese provinces (plus Beijing) on this 6th day of February, with (as of this writing) seven new cases to report.   As noted before, most of these cases appear to be sporadic, with no indications of sustained or efficient human-to-human transmission (see CIDRAP: NEJM H7N9 Epidemiology Study).

 

The first case (# 317 on FluTracker’s List) I already blogged on earlier today (see Beijing Reports 2nd H7N9 Case Of 2014), but we now have a less cumbersome account from Xinhua News.

 

Beijing reports second human H7N9 case

English.news.cn   2014-02-06 22:37:08
 

BEIJING, Feb. 6 (Xinhua) -- Beijing has confirmed this year's second human case of the H7N9 bird flu, the local health authority said Thursday.

The patient, a 73-year-old chicken farmer from Beijing's outer Huairou District, was in critical condition Thursday and was being treated at Ditan Hospital, the Beijing municipal health and family planning commission said in an updated press release at 9:30 p.m.

The man had raised, traded and slaughtered live poultry before he came down with flu symptoms and sought medication at a hospital near his home on Jan. 30, it said.

His fever persisted and his condition became serious on Wednesday, when test results indicated he was highly suspected of H7N9 infection, the document said.

The municipal disease prevention and control center confirmed the infection on the same day.

Investigators found the man had slaughtered 20 chickens between Jan. 24 and 28 with bare hands, and his hands were frostbitten with open wounds.

Altogether 35 people who were in close contact with the patient were put under medical observation, though no flu-like symptoms were detected as yet.

The capital city's first human H7N9 case was reported on Jan. 24. The patient, a man, had reportedly bought pigeons and eaten them before testing positive for H7N9 bird flu.

He died of respiratory failure, multi-infections and blood poisoning on Jan. 30.

 

 

 

Zhejiang clocks in with two new cases, both described as having `severe’ illness.

 

Zhejiang Province, two cases of human infection with the H7N9 new bird flu cases

Source: Ministry of Health and Family Planning Commission


February 6, 2014

Zhejiang Provincial Health and Family Planning Commission on February 6 briefing, the province added two cases of human infection with the H7N9 avian influenza.

Patients Jiang Moumou, male, 64 years old, Anji County, Huzhou, February 5 confirmed cases of human infection of H7N9 avian influenza. Now the condition is severe, treatment in a hospital in Hangzhou.

Patients Zheng Moumou, male, 39 years old, currently residing in Deqing County, Huzhou, February 5 confirmed cases of human infection of H7N9 avian influenza. Now the condition is severe, treatment in a hospital in Hangzhou.

 

Jiangsu Province likewise reports two new cases.

Province 2 new confirmed cases of human infection with H7N9 avian influenza

Published :2014 -02-06 

Provincial Health Department, the province confirmed cases of avian influenza H7N9 added two cases of human infection.

Patients with a Qinmou, male, 66 years old. Diagnostic Expert Group on February 6, Yancheng morning people infected with H7N9 avian influenza was confirmed cases. The patient went to farms to buy before the sick chickens 2, home cleaning after cooking slaughtered by the market. The patient is currently in a hospital for treatment in Yancheng, in critical condition.

Two patients, Huan, male, 63 years old. February 6 AM diagnosis of infected people Xuzhou expert group confirmed cases of H7N9 avian influenza. The patient's home from chickens 6, illness ago, went to a nearby farmers market shopping, there are live poultry stalls within the market. The patient is currently in a hospital for treatment of Xuzhou, in critical condition.

Provincial Panel has rushed to Yancheng, Xuzhou City guide rescue.

Up to now, the province in 2014 there were 11 cases of human infection with H7N9 avian influenza confirmed cases, 1 death.

 

Our next stop is Foshan City in Guangdong Province, about 85 miles to the Northwest of Hong Kong, where a 36 year old woman is reportedly in critical condition.

 

New confirmed cases of H7N9 in our province one case of human infection

2014-02-06 10:35:47 Ministry of Health and Family Planning Commission

Health and Family Planning Commission of Guangdong Province on February 6 Bulletin, Foshan new confirmed cases of H7N9 avian influenza case of human infection.


Case Zhang, female, 36 years old, self-employed, now living in Sanshui District, Foshan City. February 5 confirmed cases of human infection of H7N9 avian influenza, the patient is currently in critical condition in hospital in Guangzhou Hospital Wards.

 

And lastly, Hunan province reports a single case as well.

 

Hunan Province, one case of human infection with the H7N9 new bird flu cases

Time :2014 -02-06 

February 6, Hunan 1 new confirmed cases of human infection with H7N9 avian influenza, as the fifth province confirmed cases. Wu Moumou cases, female, 61 years old, who lives in Yueyang City, Hunan Miluo have live poultry contact history. Currently the patient is in a hospital in Changsha treatment. (Contributed by: Office of Emergency Management Office)

The best way to keep track of all of these cases is via  FluTrackers (absolutely indispensible) H7N9 Case Line Listing, which I refer to constantly.

Friday, November 22, 2013

A Confusing MERS-CoV Report From Qatar

image

 

 

# 8000

 


What ought to be routine announcement – that of another MERS death in the Middle East - is complicated by the fact that this patient appears to be the same one who was reported earlier this week to have fully recovered and been released from the hospital. Tracking of individual cases in the Middle East is admittedly difficult since no identifying information other than age – and usually their gender and location – are generally provided.

 

Based on FluTrackers’  MERS Case List by Country, Qatar has only announced one 48 year-old MERS case thus far, which leaves us with a bit of a mystery.

 

First a link and text from one of the many Arabic media reports this morning (no update on Qatar’s Supreme Council of Health website), and then a flashback to the announcement last Tuesday that their 48 year-old MERS case had recovered and been released.

 

Qatar Health announced the death of a resident infected with Corona

The Supreme Council for the health of the country today for the death of a resident at the age of 48 years are infected with (Corona) that causes respiratory syndrome Middle East.

 

The Supreme Council of Health Qatar in a statement that the deceased, who did not disclose his identity had been suffering from several chronic diseases.

 

With this announcement toll of victims who Hsdhm virus since the beginning of his appearance to more than 67 deaths worldwide, according to statistics from the World Health Organization.

 

Compare this report to this announcement, lifted earlier this week from Qatar’s Supreme Council of Health website, apparently announcing this same patient’s recovery.

 

 

One patient recovered, another one died in MERS coronavirus, SCH says

Doha - Tuesday, 19 Nov 2013

The Supreme Council of Health (SCH) has announced Tuesday the recovery of one resident patient inflicted with MERS coronavirus and another passed away due to the same illness.

The 48-year-old first patient was admitted to hospital for three weeks to receive proper treatment. After a course of treatment, he recovered, the SCH said in a press statement.

In the same context, the SCH announces the death of 61-year old expat patient who was battling several chronic health issues and tested positive for the MERS coronavirus.

 

 

Perhaps this discrepancy comes from an error in reporting (either today, last Tuesday, or in the reported age of one of the previous cases). It’s possible, I suppose, there might be another 48-year-old MERS case we don’t know about. There are a lot of possibilities here.


When there were but a handful of cases, keeping a reasonably accurate line-listing of patients was fairly easy. 

 

But as the number of cases has grown, and given deplorable lack of information (such as onset dates, dates of hospitalization, or dates of death) being provided by the respective Ministries of Health, the task of compiling and tracking cases has grown much harder. 

 

No one truly believes that the (roughly) 160  MERS cases identified to date represents the full burden of the disease (see Referral: Dr. Ian Mackay On `The Slowly Growing Epidemic’ Of MERS-CoV).  But these line lists have provided important information regarding the rate of new cases being detected, and their geographic spread.

 

At some point, if MERS cases continue to accrue, it will become impossible to keep reasonable track of individual cases.  We saw that with the H1N1 Pandemic virus quite early on, and that is to be expected with any emerging disease that find success in the human population.

 
But when that happens we will lose an important tracking tool, one that could have been even more valuable had public health officials in the Middle East been just a little more forthcoming with epidemiological details on these early cases.