Tuesday, December 31, 2013

Hong Kong CHP Takes Notice Of Taiwan’s H7N9 Case

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Thermal Scanner – Credit Wikipedia

 

# 8118

 

 

As you might expect, today’s big story out of Taiwan (see Taiwan CDC Reports Second Imported H7N9 Case) has not escaped the notice of the public Health Officials in Hong Kong.  The following statement has been posted on their http://www.info.gov.hk website, which also contains details on Hong Kong’s border security measures designed to identify and isolate potential carriers of the virus.

 

First, the statement, then I’ll return with a bit more on the value and history of thermal screening for disease.

 

 

CHP closely monitor a human case of avian influenza A(H7N9) in Taiwan

The Centre for Health Protection (CHP) of the Department of Health (DH) tonight (December 31) noted a confirmed human case of avian influenza A(H7N9) affecting a man aged 86 in Taiwan.

The patient, who lives in Jiangsu Province in Mainland China, travelled to Taiwan on December 17. He had onset of symptoms including loss of appetite and chest discomfort since December 19. He sought medical consultation from a local hospital on December 24. His specimen tested positive for the avian influenza A(H7N9) virus upon testing by the health authority in Taiwan today. He is currently admitted for further management.

"Locally, enhanced disease surveillance, port health measures and health education against avian influenza are ongoing. We will remain vigilant and maintain liaison with the World Health Organization (WHO) and relevant health authorities. Local surveillance activities will be modified upon the WHO's recommendations," a spokesman for the DH remarked.


All border control points (BCPs) have implemented disease prevention and control measures. Thermal imaging systems are in place for body temperature checks of inbound travellers. Suspected cases will be immediately referred to public hospitals for follow-up investigation.

Regarding health education for travellers at BCPs, distribution of pamphlets, display of posters in departure and arrival halls, in-flight public announcements, environmental health inspection and provision of regular updates to the travel industry via meetings and correspondence are all proceeding.

"Travellers, especially those returning from avian influenza A(H7N9)-affected areas and provinces with fever or respiratory symptoms, should immediately wear masks, seek medical attention and reveal their travel history to doctors. Health-care professionals should pay special attention to patients who might have contact with poultry, birds or their droppings in affected areas and provinces," the spokesman advised.

(Continue . . . )

 

 

Hong Kong has recently seen two imported cases of H7N9 themselves, and with the traditional peak of the `bird flu season’ still ahead, finds itself – like Taiwan – is very much on the front lines against this emerging virus.

 

Since fever is often a hallmark of infection, thermal imaging has been promoted as a way to protect the public and (hopefully) delay introduction of a virus into a country during a pandemic. Unfortunately, these checks haven’t produced much in the way of compelling results in the past. 

 

The problem is, not everyone who is infected will exhibit a fever.

 

  • Some may be silently incubating the virus, and will become symptomatic in another 24-48 hours
  • Others may have other symptoms, but no fever
  • Some may be taking antipyretics (fever reducers) to ease symptoms or evade detection
  • And some may simply be asymptomatic carriers of the virus.

 

Added to these, scanners can be foiled by other factors including the consumption of hot beverages or alcohol, pregnancy, menstrual period or hormonal treatments.  All of which can increase the external skin temperature and cause a false positive.

 

Inversely, intense perspiration or heavy face make-up can have a cooling effect on the skin temperature which can cause a false negative.

 

Over the years we’ve looked at a number of thermal screening studies that have tried to quantify their value.  A few highlights include:

 

In April of 2012, in EID Journal: Airport Screening For Pandemic Flu In New Zealand, we looked at a study that found that the screening methods used at New Zealand’s airport were inadequate to slow the entry of the 2009 pandemic flu into their country, detecting less than 6% of those infected.

 

Unlike some other countries in 2009, New Zealand did not employ thermal scanners, which look for arriving passengers or crew with elevated temperatures.  But even countries that employed thermal scanners and far more strict interdiction techniques during the summer of 2009 failed to keep the flu out.

 

Since there is nothing worse than being sick away from your own country and your own doctor, to little surprise in Vietnam Discovers Passengers Beating Thermal Scanners, we saw evidence of flyers taking fever-reducers to beat the airport scanners in order to get home.

 

In December of 2009, in Travel-Associated H1N1 Influenza in Singapore, I wrote about a a study in the CDC’s  EID Journal  entitled: Epidemiology of travel-associated pandemic (H1N1) 2009 infection in 116 patients, Singapore that determined that airport thermal scanners detected only 12% of travel-associated flu, and that many travelers boarded flights despite already experiencing symptoms.

 

And in June of 2010  CIDRAP carried a piece on a study of thermal scanners in New Zealand in 2008 (before the pandemic) presented at 2010’s ICEID called Thermal scanners are poor flu predictors.

 

None of which is to suggest that Hong Kong shouldn’t try to interdict infected travelers at the border, because even if the success rate is low, there may be some value in trying to limit the number of infected persons arriving into a country, particularly during the opening days and weeks of an outbreak.

 

But no one should be over-comforted by the thought of thermal scanners deployed at borders or airport terminals, as their impact on the spread of any infectious disease is likely to be limited.

A Bit More On Taiwan’s Imported H7N9 Case

 

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# 8117

 


Both Chinese language and English language media are now starting to carry the story of this morning’s announced (see Taiwan CDC Reports Second Imported H7N9 Case)  H7N9 case in Taiwan.  Thus far, no statement has appeared on the Taiwan CDC English Portal.

 

Probably the most readable English language report so far comes from the Focus Taiwan News Channel.

 

 

Taiwan reports 2nd case of imported H7N9 in 2013 (update)

2013/12/31 22:06:54

Taipei, Dec. 31 (CNA) Health authorities confirmed Tuesday that a Chinese tourist in Taiwan has been infected with the H7N9 strain of bird flu, marking the second imported H7N9 infection this year.

The infected, an 86-year-old man from Jiangsu Province, is still in Taiwan receiving treatment, though most of his 25-person tour group has already returned to China, according to the Centers for Disease Control (CDC).

Two of his daughters have stayed with him but have thus far shown no symptoms associated with the virus.

The man entered Taiwan Dec. 17 and began showing symptoms two days later, starting with a loss of appetite. On Dec. 23, he reported tightness of the chest before being rushed to an emergency room the next day, where he was put on a ventilator to treat pneumonia.

An infectious diseases experts familiar with the case said he was not surprised by the second case of H7N9 coming from China following the first back in April.

Even so, this patient's symptoms were slightly different from previously reported infections, indicating that doctors still face some difficulty in diagnosing the virus, he added.

The man's infection could mean that H7N9 has become prevalent across all of southern China even though, puzzlingly, major duck and chicken farms in the region have been found disease-free.

"Beware of the virus if you see any ducks in the Jiangnan (south of the Yangtze River) area," he cautioned.
(By Chen Ching-fang and Wesley Holzer)

WHO MERS-CoV Update – Dec 31st

 

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Coronavirus – Credit CDC PHIL

 

 

# 8116

 


The World Health Organization has published an end-of-year MERS-CoV update that catches us up with five recent cases announced out of Saudi Arabia and two cases from the UAE.  The latest case from the UAE is the (asymptomatic) wife of a case announced last week, who is reported now as having died.

 

 

31/12/2013

Middle East respiratory syndrome coronavirus (MERS-CoV) – update


Disease outbreak news


31 December 2013 – On 25 December 2013, WHO has been informed of five additional laboratory-confirmed case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in Saudi Arabia.

One of the cases is a 57 year-old male from Riyadh who was hospitalized on 17 December,  2013 and is currently in an Intensive Care Unit (ICU). He was laboratory confirmed on 19 December,  2013. He has underlying chronic diseases. There are no known exposures to animals or a laboratory-confirmed case, and the case has no history of traveling outside Riyadh region.

Second case is a 73 year-old male national, from Riyadh who developed respiratory symptoms and was transferred to an intensive care unit on 25 November 2013, and died on 17 December 2013. On 19 December 2013, he was laboratory confirmed for MERS-CoV. There are no known exposures to animals or a laboratory-confirmed case. In addition, he has no history of travel outside of Riyadh

Three additional cases (two males and one female) are health care workers who have not reported any symptoms.

On December 26, WHO has been informed of one new confirmed case of MERS CoV from the United Arab Emirates (UAE).  In addition, UAE announced the death of the 68 year old male reported on 22 December 2013.

The new case is a 59 year-old female from Sharjah, and is the wife of the 68 year old male reported on 22 December, 2013. She is reported to have no symptoms, no history of contact with animals and no travel history. She is currently in hospital under isolation. Other contacts have been screened and are negative for MERS-CoV.

Globally, from September 2012 to date, WHO has been informed of a total of 176 laboratory-confirmed cases of infection with MERS-CoV, including 74 deaths.

Based on the current situation and available information, WHO encourages all Member States to continue their surveillance for severe acute respiratory infections (SARI) and to carefully review any unusual patterns.

Health care providers are advised to maintain vigilance. Recent travellers returning from the Middle East who develop SARI should be tested for MERS-CoV as advised in the current surveillance recommendations.

Patients diagnosed and reported to date have had respiratory disease as their primary illness. Diarrhoea is commonly reported among the patients and severe complications include renal failure and acute respiratory distress syndrome (ARDS) with shock. It is possible that severely immunocompromised patients can present with atypical signs and symptoms.

Health care facilities are reminded of the importance of systematic implementation of infection prevention and control (IPC). Health care facilities that provide care for patients suspected or confirmed with MERS-CoV infection should take appropriate measures to decrease the risk of transmission of the virus to other patients, health care workers and visitors.
All Member States are reminded to promptly assess and notify WHO of any new case of infection with MERS-CoV, along with information about potential exposures that may have resulted in infection and a description of the clinical course. Investigation into the source of exposure should promptly be initiated to identify the mode of exposure, so that further transmission of the virus can be prevented.

People at high risk of severe disease due to MERS-CoV should avoid close contact with animals when visiting farms or barn areas where the virus is known to be potentially circulating. For the general public, when visiting a farm or a barn, general hygiene measures, such as regular hand washing before and after touching animals, avoiding contact with sick animals, and following food hygiene practices, should be adhered to.

WHO does not advise special screening at points of entry with regard to this event nor does it currently recommend the application of any travel or trade restrictions.

WHO has convened an Emergency Committee under the International Health Regulations (IHR) to advise the Director-General on the status of the current situation. The Emergency Committee, which comprises international experts from all WHO Regions, unanimously advised that, with the information now available, and using a risk-assessment approach, the conditions for a Public Health Emergency of International Concern (PHEIC) have not at present been met.

Taiwan CDC Reports Second Imported H7N9 Case

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# 8116

 

Last April Taiwan was the first place, outside of mainland China, to detect an H7N9 case (see Taiwan Confirms First Imported Case Of H7N9) – an event that not only sparked enhanced surveillance, but also a fast track vaccine development program (see Taiwan Adjusts Their H7N9 Vaccine Production Outlook).

 

Today, Taiwan’s CDC has released a press statement indicating that they’ve detected a new imported case of H7N9 – this time an 86 year old man from  Jiangsu Province, China who appears to have been part of a tour group.

 

Below you’ll find the (machine translated) statement.   I expect we’ll be hearing a good deal more on this later today.

 

Command Center today (12/31) evening to confirm an imported H7N9 influenza cases. Case was a resident in mainland China, Changzhou City, Jiangsu Province 86 year old male, 12/17 inbound tourism in Taiwan, 12/19 began to loss of appetite, 12/23 chest tightness, 12/24 am to hospital emergency medical care, because both sides of the day pneumonia and ventilator ICU stay, 12/26 administered Tamiflu, 12/27 physicians reported to the Centers for Disease Control Department for examination and specimen collection, test results today to determine the present continuous treatment in the intensive care ward. To the press release time deadline, the command center has confirmed the patient group with 25 people who were 12 and 22/24 return to the mainland, their two daughters continued to stay in Taiwan to take care of patients, they no symptoms.

Command Center said the patient during the journey to Taiwan, visited included Taoyuan County, Taipei City, New Taipei City, Taichung City, Chiayi City, Kaohsiung, Taitung, Hualien County and other counties of the famous attractions, patients in the journey in no fever or cough, detailed travel history and had hotel accommodation information, command centers are engraved with a detailed guide to confirm, to facilitate contacts grasp travel period. Now through the district control center, local health officers launched against people travel during the time of investigation, and strive to really grasp all possible close contacts and inventoried tube, other health care hospital for the treatment of patients and other related contacts, has been investigated and inventoried, appropriate protection for those who are not, will be given prophylaxis. Public health workers for all close contacts caught giving full health education and H7N9 influenza independent health management notice and actively track to lift the tube, if contact occurs with fever, cough, influenza-like symptoms, please wear a mask for medical treatment, and initiative to inform the physician contact history.

WHO also sync command center informed and notified the Chinese mainland and Hong Kong and Macao contact window through IHR contact window.

In response to the Chinese mainland and Hong Kong continued to appear since the autumn H7N9 flu cases, indicating the risk of epidemics and the threat increases. Present, except in Guangdong Province and Zhejiang Province, Jiangsu Province, will travel epidemic upgraded to second level: Alert (Alert), the remaining provinces (excluding Hong Kong and Macau) as the first stage: Note (Watch), the command center to alert plan infected people, it is important to maintain good hygiene, avoid contact with birds. Also, once again reminded the people, to the Chinese mainland, the class should avoid contact with birds, especially not to pick up dead birds; eating chickens, ducks, geese and eggs to be cooked;, and should be implemented hand-washing and other personal hygiene measures to avoid infection. When you return home if fever or flu-like symptoms, they should inform the airline personnel and airport and port of quarantine officers; such as after returning the above symptoms should wear a mask and seek medical advice and inform the physician contact history and travel history. Latest epidemic diseases and other related information can be found in the Agency website ( http://www.cdc.gov.tw ) the "H7N9 flu Corner" and "International Travel Information" area, or call the toll-free hotline and caring people informed epidemic 1922 ( or 0800-001922) contact.

  • The draft date :2013-12-31
  • Update Date :2013-12-31
  • Maintenance Unit: Public Relations Office

    Hong Kong: Epidemiological Update & Letter To Doctors On H9N2 Case

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    Credit Hong Kong’s CHP

     



    # 8115

     

    Although not considered as serious as H7N9 or H5N1, the announcement yesterday (see Hong Kong: Isolation & Treatment Of An H9N2 Patient) recently arrived from neighboring Shenzhen has unleashed another epidemiological investigation, and forced the medical surveillance of this patient’s recent contacts. 

     

    As part of their response, late yesterday the Hong Kong CHP issued a letter to local doctors and hospitals and this morning published a follow up press release, both of which are excerpted below.

     

    Our first stop, the CHP notification letter to local doctors.

     

    Surveillance And Epidemiology Branch 
    Our Ref. :   (116) in DH SEB CD/8/6/1 Pt.27
    30 December, 2013


    Dear Doctor,


    A confirmed imported case of Influenza A(H9N2) infection

    We are writing to inform you that we have confirmed an imported human case of influenza A (H9N2) infection  involving an 86-year-old man with underlying illnesses.  He lived in Shenzhen with his daughter and presented with low grade fever, chills, cough and sputum since 28 December, 2013. He travelled back to Hong Kong and was admitted to North District Hospital on the same day. Sputum collected on 28 December was tested positive for influenza A M gene and negative for H1/H3 and was subsequently confirmed positive for influenza A(H9N2) by Public Health  Laboratory Services Branch  (PHLSB) today. His condition is stable with fever subsided since 29 December and currently being isolated in hospital.


    Investigations by the Centre for Health Protection (CHP) revealed that the patient had no recent poultry contact,  consumption of undercooked poultry, or contact with patients. His home contact is asymptomatic.

    Human influenza A (H9N2) infection  is not new to Hong Kong and cases were reported in 1999, 2003, 2007, 2008 and 2009.  Unlike influenza A (H5N1) infection, previous cases with influenza A (H9N2) infection usually presented with mild illness and all recovered. According to scientific literature and local poultry surveillance data, influenza A (H9N2) virus is commonly found in the poultry population in this region and recently it was noted that it could also be transmitted by sparrows and crows.  Sporadic cases of human influenza A (H9N2) infection are anticipated in Hong Kong.


    Influenza A (H9) is a statutory notifiable disease in Hong Kong. Any suspected case meeting the reporting criteria (https://ceno.chp.gov.hk/casedef/casedef.pdf) should be immediately reported to the Central Notification Office of CHP via fax (2477 2770), phone (2477 2772) or CENO On-line (www.chp.gov.hk/ceno). Please also contact the Medical Control Officer (MCO) of DH at Pager: 7116 3300 call 9179 when reporting any suspected case.


    For updates on the latest situation of avian influenza, please visit CHP website at  http://www.chp.gov.hk/en/view_content/24244.html. Thank you for your ongoing support in combating communicable diseases.


    Yours faithfully,

    (Dr. Yonnie LAM)
    for Controller, Centre for Health Protection
    Department of Health

     

    And as we’ve come to expect, Hong Kong’s CHP continues to provide daily updates whenever a they detect an event with potential public health ramifications.   The good news, aside from the patients mild symptoms and no signs of spread, is that preliminary genetic analysis of the virus reveals `no evidence of genetic reassortment with genes of human influenza origin or resistance to the antiviral Tamiflu.’

    31 December 2013

    Epidemiological investigation and follow-up actions by CHP on confirmed human case of avian influenza A(H9N2) 

    The Centre for Health Protection (CHP) of the Department of Health (DH) today (December 31) provided an update on the confirmed human case of avian influenza A(H9N2) affecting a man aged 86.

    "The epidemiological investigations, enhanced disease surveillance, port health measures and health education against avian influenza are all ongoing," a spokesman for the DH said.

    The patient's home contact in Shenzhen has remained asymptomatic.

    The 51 health-care workers (HCWs) of North District Hospital (NDH) and the ambulance service remain under medical surveillance. Among them, an HCW of NDH presented with productive cough and sore throat and the respiratory specimen tested negative for the influenza A virus upon testing by the CHP's Public Health Laboratory Services Branch (PHLSB).

    The officer who handled the patient upon his entry at Lo Wu Border Control Point is also asymptomatic. He has been put under medical surveillance. So far, there are no newly located contacts.

    As the patient was staying in Shenzhen for the whole incubation period, the case is classified as an imported one. The CHP has passed investigation findings to the health authority of Guangdong for follow-up.

    "Upon analysis by the PHLSB, the genes of the virus were determined to be of avian origin. They do not show significant differences from avian influenza viruses detected in Hong Kong and the Mainland in recent years. There is no evidence of genetic reassortment with genes of human influenza origin or resistance to the antiviral Tamiflu. We will continue to liaise and share the gene sequence with other health authorities based on established arrangements," the spokesman remarked.

    The public is advised to avoid contact with poultry and wild birds, including chickens, ducks and sparrows.

    "Travellers, especially those returning from avian influenza-affected areas and provinces with fever or respiratory symptoms, should immediately wear masks, seek medical attention and reveal their travel history to doctors. Health-care professionals should pay special attention to patients who might have had contact with poultry, birds or their droppings in affected areas and provinces," the spokesman advised.

    <SNIP>

    Ends/Tuesday, December 31, 2013

     

    Anytime public health authorities detect a novel influenza virus infection in a human, understandably alarm bells tend to go off. But we need to keep in mind that no one really knows how rare – or common – such infections really are.

     

    The vast majority of people who develop `flu-like’ symptoms around the world never seek medical care, and even among the minority that do, most are never tested. Certainly not with lab tests that would pick up a novel influenza virus.

     

    With enhanced surveillance in Hong Kong for both MERS-CoV and Avian H7N9 (and H5N1), however, the odds of detecting novel flu cases goes up considerably.  Whether we are seeing an actual uptick in the number of these types of infections, or are just getting better at detecting them, is something we don’t have enough data to discern.

     

    But with enhanced surveillance ongoing in Hong Kong, and across Asia, for these three strains we are also gaining information about H6N1, H10N8, and nH9N2.

     

    The serendipitous result of surveillance work is that you sometimes can learn a good deal about things you weren’t looking for at the time.  And that can often pay unexpected dividends further down the line.

    Monday, December 30, 2013

    Video: Press Statement By Hong Kong CHP On H9N2 Case

     

     

     

    # 8114

     

     

    A brief follow up to this morning’s more detailed report: Hong Kong: Isolation & Treatment Of An H9N2 Patient,  Hong Kong Centre For Health Protection Controller Dr Leung Ting-hung gave a brief press statement regarding this case, and the video and accompanying story are carried on News.gov.hk.

     

    Man treated for H9N2

    December 30, 2013

    The Centre for Health Protection is investigating a confirmed human case of influenza A (H9N2) affecting a man aged 86.

    Briefing the media today, the centre’s Controller Dr Leung Ting-hung said the patient is a Hong Kong resident living in Shenzhen.

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    He has underlying illnesses and has developed chills and a cough since December 28. He returned to Hong Kong on the same day and was admitted to a North District Hospital isolation ward.

    He was transferred to Princess Margaret Hospital today in stable condition. His clinical diagnosis was chest infection.

    He had no recent poultry contact, consumption of undercooked poultry, or contact with patients. His home contact in Shenzhen is asymptomatic.

    Over 50 healthcare workers at the hospital and ambulance officers have been put under medical surveillance.

    The centre will notify Guangdong authorities, the World Health Organisation (WHO), and other agencies of the case.

     

     

    As we discussed in my previous blog – while rare - this is not the first time that H9N2 has shown up in Hong Kong, and most cases have produced only mild illness in the past.

    Hong Kong: Isolation & Treatment Of An H9N2 Patient

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    # 8113

     

     

    One of the side benefits of China’s stepped up surveillance for the H7N9 influenza virus is that other, uncommon influenza infections are being detected as well.  Earlier this month, in HK CHP Notified Of Fatal H10N8 Infection In Jiangxi,  we saw the first confirmation of a human H10N8 infection, and last summer, Taiwan CDC Reports Human Infection With Avian H6N1.

     

    While we normally talk about the seasonal (and variant) H1N1 and H3N2 viruses, along with the avian H5N1 and newly emerging H7N9 viruses, we’ve covered other rarely seen flu viruses that have been detected in humans, as well.  A small sampling includes:

     

    In 2003, an outbreak of H7N7 at a poultry farm in the Netherlands went on to infect at least 89 people (mostly mildly, but 1 death), and many more may have been infected subclinically.

    In Egypt - in 2004 -  2 infants were shown to be infected by the H10N7 avian flu virus.

    In 2006 1 person in the UK was confirmed to have contracted H7N3, and the following year, 4 people tested positive for H7N2 – both following local outbreaks in poultry.

    In 2012, in EID Journal: Human Infection With H10N7 Avian Influenza, we learned of H10N7 avian influenza virus detected in two poultry abattoir workers in Australia from 2010. Although 7 abattoir workers reported symptoms, only 2 tested positive for the H10 virus.

    And this past summer, in ECDC Update & Assessment: Human Infection By Avian H7N7 In Italy, we saw 3 human infections with this H7 virus.

     

    Since testing for non-standard influenza viruses is rarely done, we honestly don’t know how often these seldom seen influenza strains infect humans.  But it is probably more common than the numbers above would have us think.

     

    Not mentioned above, but also a `player’ in the world of avian influenza, is the H9N2 virus, which is ubiquitous in poultry across much of Asia, has been known to infect humans in the past - and perhaps most notoriously - contributed some of its internal genes to both H5N1 and the H7N9 virus.

     

    In September of 2013, in the World Health Organization document Antigenic and genetic characteristics of A(H5N1), A(H7N3), A(H9N2) and variant influenza viruses and candidate vaccine viruses developed for potential use in human vaccines, H9N2 is described:

     

    Influenza A(H9N2)


    Influenza A(H9N2) viruses are enzootic in poultry populations in parts of Africa, Asia and the Middle East. The majority of viruses that have been sequenced belong to the G1, chicken/Beijing (Y280/G9), or Eurasian  clades. Since  1998, when the first human infection was detected, the isolation of A(H9N2) viruses from humans and swine has been reported infrequently. In all human cases the associated disease symptoms have been mild and there has been no evidence of human-to-human transmission. 

     

    Over the past 15 years H9N2 has been reported a handful of times, including in Hong Kong in 1999 (2 cases), 2003 (1 case), and 2007 (1 case). . Several additional human H9N2 virus infections were reported from China in 1998-99, and all known cases were mild.  More recently, in 2011 we learned Bangladesh To Share H9N2 Bird Flu Virus after detecting a case there.

     

    Today, we get the following statement on a case from Shenzhen, China which is being treated at a hospital in neighboring Hong Kong.

     

    Epidemiological investigation and follow-up actions by CHP on confirmed human case of influenza A(H9N2)


    The Centre for Health Protection (CHP) of the Department of Health (DH) is today (December 30) investigating a confirmed human case of influenza A(H9N2) affecting a man aged 86.

    The patient is a Hong Kong resident living in Huangbeiling, Luohu, Shenzhen. He has underlying illnesses and has developed chills and cough with sputum since December 28. Upon entry at Lo Wu Border Control Point (BCP) on the same day, he was transferred by ambulance direct to the Accident and Emergency Department of North District Hospital (NDH), where he presented with low fever. He was then admitted to the isolation ward. He was transferred to Princess Margaret Hospital today for further management.

    His clinical diagnosis was chest infection. He has been in stable condition all along and is currently afebrile.

    His sputum specimen tested positive for the influenza A(H9N2) virus upon testing by the CHP's Public Health Laboratory Services Branch.

    "The epidemiological investigations, enhanced disease surveillance, port health measures and health education against avian influenza are all ongoing," a spokesman for the DH remarked.

    Investigations by the CHP revealed that the patient had no recent poultry contact, consumption of undercooked poultry, or contact with patients. His home contact in Shenzhen has remained asymptomatic.

    Over 50 health-care workers of NDH and the ambulance service have been put under medical surveillance.

    "The H9N2 virus is of avian origin and has been isolated mainly from poultry. Rare and sporadic human cases have been reported and are generally mild respiratory tract infections. The public should avoid contact with poultry and other birds, including chickens, ducks and sparrows," the spokesman explained.

    Influenza A(H9) is a local statutorily notifiable infectious disease. Two local cases were reported in 1999. One local case was respectively filed each in 2003 and 2007. An imported case was recorded in 2008 while an imported case and one with the source of infection unclassified were filed in 2009. All are mild infections and the patients have recovered. No deaths have been recorded so far.

    Locally, enhanced surveillance over suspected cases in public and private hospitals is under way.

    As the patient was staying in Shenzhen for the whole incubation period, the CHP will inform the health authority of Guangdong of the case for necessary investigation and follow-up action.

    The case will also be notified to the World Health Organization (WHO), the National Health and Family Planning Commission, and the health authority of Macau.

    The CHP will issue letters to doctors and hospitals to keep them abreast of the latest situation.

    "We will remain vigilant and maintain liaison with the WHO, the Mainland and overseas health authorities. Local surveillance activities will be modified according to the WHO's recommendations," the spokesman said.

    "All BCPs have implemented disease prevention and control measures. Thermal imaging systems are in place for body temperature checks of inbound travellers. Suspected cases will be immediately referred to public hospitals for follow-up investigation," the spokesman added.

    Regarding health education for travellers, distribution of pamphlets, display of posters in departure and arrival halls, in-flight public announcements, environmental health inspection and provision of regular updates to the travel industry via meetings and correspondence are all proceeding.

    "We have enhanced publicity and health education against avian influenza. The CHP has also sent letters to government departments and related organisations to reinforce health advice against avian influenza," the spokesman said.

    "Travellers, especially those returning from avian influenza-affected areas and provinces with fever or respiratory symptoms, should immediately wear masks, seek medical attention and reveal their travel history to doctors. Health-care professionals should pay special attention to patients who might have had contact with poultry, birds or their droppings in affected areas and provinces," the spokesman advised.

    Members of the public should remain vigilant and take heed of the preventive advice against avian influenza below:

    • Do not visit live poultry markets. Avoid contact with poultry, birds and their droppings. If contact has been made, thoroughly wash hands with soap;
    • Poultry and eggs should be thoroughly cooked before eating;
    • Wash hands frequently with soap, especially before touching the mouth, nose or eyes, handling food or eating; after going to the toilet or touching public installations or equipment (including escalator handrails, elevator control panels and door knobs); or when hands are dirtied by respiratory secretions after coughing or sneezing;
    • Cover the nose and mouth while sneezing or coughing, hold the spit with a tissue and put it into a covered dustbin;
    • Avoid crowded places and contact with fever patients; and
    • Wear masks when respiratory symptoms develop or when taking care of fever patients.


    The public may visit the CHP's avian influenza page (www.chp.gov.hk/en/view_content/24244.html) and website (www.chp.gov.hk/files/pdf/global_statistics_avian_influenza_e.pdf) for more information on avian influenza-affected areas and provinces.

    Ends/Monday, December 30, 2013
    Issued at HKT 18:43

     

    Although human infections with the H9N2 virus have generally been mild, until the spring of this year, the same could have been said for the H7 avian viruses.  Then H7N9 changed the rules.

     

    While we shouldn’t make too much out of today’s announcement of a single H9N2 virus in Hong Kong, it as been the subject of a fair amount of study in recent years, and is one of the avian viruses that the WHO, and other agencies, watch carefully for signs of adaptation or change.

     

    In early 2011, in PNAS: Reassortment Of H1N1 And H9N2 Avian viruses we saw research from Chinese scientists that created – using reverse genetics – 128 reassorted viruses from the avian H9N2 virus and the (formerly pandemic) H1N1 virus.

     

    In mouse testing, they found half of the hybrid viruses were biologically `fit’ as far as replication goes, and 8 hybrids were significantly more pathogenic than either of their parental viruses.

     

    Research such as this shows the potential for the H9N2 virus to move towards a more `humanized’ pathogen. And with H1N1 and H9N2 both known to be circulating in pigs in Asia, there are ample opportunities for them to co-infect the same host.

    A few notable H9N2 stories from the past include:

     

     

    Unlike the H7 and H5 avian flu strains, poultry (and swine) infections by the H9N2 virus are not required to be reported to the OIE.  So we have far less data on how widespread H9N2 might be.

     

    In 2009, we saw that sometimes a pandemic virus will emerge from an unexpected source, and with a surprising lineage. While the world was waiting for an H5 bird flu to emerge from Asia, we were blindsided by a H1N1 swine flu from North America.

     

    All of which highlights the importance of establishing better global surveillance of humans, and farm animals, for the next emerging influenza virus. 

    Sunday, December 29, 2013

    Referral: Dr. Ian Mackay On H7N9 Activity In 2013

     

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    Weekly Accumulation Chart – Credit Dr. Ian Mackay

     



    # 8112

     

    After a sudden avalanche of cases during the spring, the number of new H7N9 cases in China declined over the summer, and has only recently begun to rise again with the arrival of winter.  

     

    Today  Professor Ian Mackay has updated his H7N9 activity chart for the year (see above) on his VDU Blog  and provides some thoughts on what we’ve seen out of this virus so far.

     

    Influenza A(H7N9) virus case accumulation for 2013...

    Sure a full 12-months of H7N9 in humans hasn't passed yet, but 2013 is coming to a close.


    I have 148 H7N9 cases worldwide including deaths and the asymptomatic boy from Beijing who seems to still be off the official tallies for some reason. WHO have not had an official tally of fatal cases in their recent 2 disease outbreak news posts, the last with a tally was 6-Nov in which 45 deaths were recorded with 6 cases remaining in hospital and 88 having been discharged. Hong Kong's Centre for Health Protection (CHP) maintains a running tally of mainland China cases With the recent death of a Hong Kong man the tally of fatal cases rest around 46 (PFC of 31.1%).

    (Continue . . . .)

    Saturday, December 28, 2013

    Radio Interview With Robert Herriman

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    # 8111

     

    I’ve done a few radio and TV shows in the past, and of the two, I prefer radio. Mostly because the last time I did a TV show, a friend commented that it looked like I’d put on more weight. 

     

    I explained the camera always adds 15 pounds, to which he replied, `Just how many cameras did they have on you?’

     

    Moving on  . . .  last night I had the pleasure of pre-recording a segment with Microbiologist Robert Herriman, host of the Outbreak News This Week radio show.   Although broadcast live Saturday mornings on several radio stations in the Tampa Bay Area, his show is also streamed live online, and archived as a podcast for later download here.

     

    In recent weeks his guests have included Professor Vincent Racaniello, Christina Nelson, MD, MPH, FAAP, Medical Epidemiologist with the CDC’s DVBID, Abbey Canon, DVM, MPH, LT, USPHS , Epidemic Intelligence Service Officer, Roger S. Nasci, PhD, Chief of the Arboviral Diseases Branch at the CDC’s DVBID, among others.

     

    Robert and I discussed this season’s H1N1 seasonal flu and the MERS-CoV outbreak in the Middle East, after which he counts down his top 10 infectious disease stories of 2013.

     

    You can listen to today’s show, and catch up earlier shows, at http://internetradiopros.com/outbreak/

     

    I had a good time, and would like to thank Robert for inviting me.  I expect we’ll do this again in a few weeks.

    HHMI’s Holiday Lecture Series: 2013

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    # 8110

     

    In 2010 I highlighted an online (and free) holiday lecture series  offered by HHMI (Howard Hughes Medical Institute) that focused on Infectious Diseases. These four (roughly 1 hour lectures) were geared for and delivered to an audience of high school science students.

     

    Last year, in HHMI’s Holiday Lecture Series: 2012, I highlighted this series again, this time featuring four lectures on our changing planet.

     

    These lecture series are a yearly event, and for nearly two decades  they have focused on a variety of topics, including: Cancer, Genomics, Biodiversity, Immunology, Neuroscience, and Infectious Diseases. This year, the focus is on Medicine in the Genomic Era, again with 4 hour-long lectures available. 

     

    A link, with a brief description, follows:

     

     

    The 2013 Holiday Lectures are now available
    via on-demand streaming! Click the thumbnail above
    or
    follow this link to view!

    Sixty years after James Watson and Francis Crick revealed the structure of the DNA double helix and only a decade after scientists published the first complete read-through of all three billion DNA bases in the human genome, the ability to routinely sequence and analyze individual genomes is revolutionizing the practice of medicine—from how diseases are first diagnosed to how they are treated and managed.

    In the 2013 Holiday Lectures on Science, Charles L. Sawyers of Memorial Sloan-Kettering Cancer Center and Christopher A. Walsh of Boston Children’s Hospital will reveal the breathtaking pace of discoveries into the genetic causes of various types of cancers and diseases of the nervous system, and discuss the impact of those discoveries on our understanding of normal human development and disease.

     

     

    For those who would like to sample the earlier lectures, their are 80 of them available as free podcasts through iTunes.

    The rest of the Howard Hughes Medical Institute  website is well worth exploring as well, for it contains numerous short science films, virtual laboratories, and interactive mini-lessons, all designed to feed your `inner science geek’.

     

    This is a veritable treasure trove for science geeks everywhere, and I’m looking forward to sampling many of these lectures over the holidays.

    Friday, December 27, 2013

    Spot Shortages Of Tamiflu Reported In Some Regions

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    Photo Credit – Wikipedia

     


    # 8109

     

    With the 2013-14 influenza season now well underway, and concerns over the severity of the H1N1 virus – particularly in younger patients and those with co-morbidities – the CDC is urging doctors to consider the early use of antivirals in high risk patients with suspected or confirmed influenza (see CDC HAN Advisory On Early pH1N1 Influenza Activity).

     

    While there does not seem to be a national shortage of oseltamivir (Tamiflu ®) – the most commonly prescribed antiviral for influenza – in a few regions (mainly in the South) that have already been hit hard by the flu, some pharmacies are reporting trouble keeping the drug in stock.

     

    A couple of  reports on these shortages, after which I’ll be back with a little more on Tamiflu, and this year’s H1N1 flu.

     

    Shortage in flu medication worries pharmacists

    LITTLE ROCK, Ark. (KTHV) - "We can't find the regular adult dose anywhere right now," Dr. Ray Turnage explained.

    Turnage is one of many pharmacists dealing with a shortage of Tamiflu. He said, "There's only one manufacturer for that drug and nationwide all the wholesalers are saying it's a manufacture delay."

    Tamiflu is the only medication on the market used to treat the flu and with a shortage in the drug, it could create problems for patients needing it. "Probably the demand is exceeding their supply. So that's the problem is we can't even get adult doses right now," Turnage continued.

    Although there have been very minimal cases of the flu this year in Little Rock, with 3 to 4 months left in the flu season, that could change pretty quickly. If it does, Tamiflu in stock could disappear. Turnage said, "That's part of the situation is a few families can, if they can find it, can take all that the pharmacy may have."

    (Continue . . .)

     

    Shortage reports on Tamiflu in Atlanta, local pharmacies stocked – WSOC-TV

     

    The bottom line is, that if you are prescribed Tamiflu, you may have to call around to more than one pharmacy to locate the drug.


    While Tamiflu continues to get a strong recommendation from the CDC (see CDC Research On Benefits Of Antivirals For Uncomplicated Influenza), you’ll find no shortage of critics of the drug.  Due in large part to a prolonged reluctance on the part of Roche laboratories to release all of their clinical trial data, and a not totally undeserved reputation of `Big Pharma’ to massage test results. 

     

    This has resulted in a vociferous backlash against the government stockpiling of Tamiflu in some quarters (see Dr. Ben Goldacre Opinion Piece). 

     

    While academics and activists tend to have a dim view of Roche and their antiviral drug, clinicians obviously see value in oseltamivir,  and continue to prescribe it.  The CDC continues to recommend its use – particularly for high-risk influenza patients - or for the treatment of novel flu (see 2012 blog The CDC Responds To The Cochrane Group’s Tamiflu Study).

     

    Although this year’s flu season is being billed in the media as `The Return of Swine Flu’, in truth, the H1N1 virus never departed.  But it has been dominated in North America by the H3N2 virus for the past couple of years.   The following snapshot of last year’s moderately severe flu season comes from last summer’s  MMWR Influenza Activity — United States, 2012–13 Season and Composition of the 2013–14 Influenza Vaccine.

     

    Among the seasonal influenza A viruses, 34,922 (68%) were subtyped; 33,423 (96%) were influenza A (H3N2) viruses, and 1,497 (4%) were pH1N1 viruses. In addition, two variant influenza A (H3N2v) viruses were identified.

     

    The season before that (2011-12) was the mildest flu season in decades (see 2011-2012 Flu Season Draws to a Close), that while H3N2 dominated, neither strain had a huge impact.

     

    The truth is, flu seasons can vary greatly in impact from year-to-year,and with two influenza A strains in global circulation, we usually see one strain or the other dominate (although what strain is dominant in North America my differ from what is dominant in Europe, or Asia the same year).  Often we see 2 or 3 years with one strain in control, and then – as community immunity levels wane – the other takes hold.

     

    The CDC’s most recent attempt to estimate the number of deaths associated with flu in the United States finds:

     

    An August 27, 2010 MMWR report entitled “Thompson MG et al. Updated Estimates of Mortality Associated with Seasonal Influenza through the 2006-2007 Influenza Season. MMWR 2010; 59(33): 1057-1062.," provides updated estimates of the range of flu-associated deaths that occurred in the United States during the three decades prior to 2007. CDC estimates that from the 1976-1977 season to the 2006-2007 flu season, flu-associated deaths ranged from a low of about 3,000 to a high of about 49,000 people.

     

    As much as a 16-fold difference in the number of estimated deaths between a mild flu season, and a heavy one. 

     

    Thus far, its been H1N1’s year to roar, and since that strain often impacts those under the age of 65, it tends to get more publicity. The flu death of a young adult from influenza is more unexpected, and has more societal impact, than that of an octagenarian.  And this year, sadly, we are seeing a fair number of such reports (see Texas DSHS Statement On Recent Spike In Flu Activity).

     

    Regardless of the strain of flu in circulation, you are much better off avoiding infection rather than treating it. So while it may only provide moderate protection, getting the flu shot each year is cheap insurance. 


    That, and following good flu hygiene practices (covering coughs, washing hands frequently, staying home when sick, avoiding close contact with those who are sick),  are your best defense against our yearly flu epidemic.

    WHO MERS-CoV Update – Dec 26th

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    Coronavirus – Credit CDC PHIL

     

    # 8108


    This morning the World Health Organization published a GAR update on the 4 MERS cases announced last Friday (see Saudi Arabia Announces 4 New MERS Cases (1 Fatal)) – since then, the Saudi MOH has announced five additional cases.

     

    Of note, out of the nine new cases announced in the past week, five have been reported as being asymptomatic health care workers (HCWs).

     

    At this point, after over 15 months and the experience gained  treating 140+ cases, one would hope that healthcare facilities in Saudi Arabia are employing adequate infection control precautions to prevent this sort of transmission.

     

    Yet we continue to see indications of nosocomial transmission.

     

    And while mild or asymptomatic infection would seem to be a good thing (and for the person infected, it is), the number of these cases we’re seeing among  known patient contacts suggest that the virus may be able to spread stealthily – and under the surveillance radar – in the community. 

     

    Which could help explain why sporadic severe cases – seemingly without exposure history - continue to pop up on the Arabian peninsula.

     

    But, again on the plus side, more mild and asymptomatic infections helps to drive the case fatality rate down.  But until good seroprevalence studies can be conducted in these countries, attempts to describe the actual incidence and spread of the virus remains more guesswork than science.

     

    Here then is this morning’s update.  Follow the link to read it in its entirety.

     

     

    Middle East respiratory syndrome coronavirus (MERS-CoV) - update

    Disease outbreak news

    27 December 2013 - On 20 December 2013, WHO has been informed of four additional laboratory-confirmed cases of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in Saudi Arabia.

     

    Two cases are female health workers from Riyadh who have not reported any symptoms.

     

    The third case is a 53 year-old male from Ryadh with underlying chronic diseases. He was hospitalized on November 26 and is currently receiving treatment in an intensive care unit. He had no exposure to animals and no travel history outside Riyadh region. He had contact with a confirmed case.

     

    The fourth case is a 73 year-old male from Riyadh with underlying chronic diseases who died on December 18, three days after being hospitalized. He had exposure to animals but no travel history.

     

    Globally, from September 2012 to date, WHO has been informed of a total of 170 laboratory-confirmed cases of infection with MERS-CoV, including 72 deaths.

    (Continue . . . )

    Thursday, December 26, 2013

    Hong Kong: Epidemiological Update On H7N9

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    # 8107

     

    Via Hong Kong’s CHP’s bi-weekly online journal Communicable Diseases Watch, we get an Update on the situation of avian influenza A(H7N9) infection reported by Dr Conan Tsang, Medical and Health Officer, Respiratory Disease Office, Surveillance and Epidemiology Branch, CHP. 

     

    This update – dated December 24th - adds 14 new cases since the last update in August of 2013.  I’ve only included a few excerpts, follow the link to read it in its entirety.

     

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    Geographic spread of cases  - Credit HK CHP

     

    Update on the situation of avian influenza A(H7N9) infection

    Reported by Dr Conan Tsang, Medical and Health Officer, Respiratory Disease Office, Surveillance
    and Epidemiology Branch, CHP.


    Since the publication of last issue concerning avian influenza A(H7N9) infection (http://www.chp.gov.hk/files/pdf/cdw_v10_16.pdf), 14 more confirmed cases of human infection with avian influenza A(H7N9) virus were reported (as of December 20, 2013). Among these cases, two of them were likely imported cases from Shenzhen and were confirmed in Hong Kong (HK) on December 2 and 6 respectively, whereas 6 cases were reported from Guangdong Province between August 10 and December 19, 2013.

    As of December 20, 2013, the National Health and Family Planning Commission (NHFPC) has reported 144 cases of human infection with avian influenza A(H7N9) virus across 10 provinces and 2 municipalities, including 47 deaths. The health authority of Taiwan also reported one imported case from Jiangsu Province on April 24, 2013. Including the 2 cases confirmed in HK, there are a total of 147 cases. The geographical distribution of the cases is summarized in Figure 1.


    Based on the available information, the age of the cases ranged from 2 to 91 years (median: 60 years) and involved 104 males and 43 females. Forty-seven cases died with a case fatality rate of around 32%. The onset dates of the confirmed cases were between February 19 and December 11, 2013 (Figure 2).

    (Continue . . . )

     

    While obviously a huge concern, thus far we’ve not seen any evidence of sustained or efficient human-to-human transmission of the H7N9 virus.The WHO Avian Flu Risk Assessment – December, provides the following risk assessment on this emerging avian flu virus:

     

    Overall public health risk assessment for avian influenza A(H7N9) virus: Sporadic human cases and small clusters would not be unexpected in previously affected and possibly neighbouring areas/countries of China. The current likelihood of community-level spread of this virus is considered to be low.

    Continued vigilance is needed within China and neighbouring areas to detect infections in animals and humans. WHO advises countries to continue surveillance and other preparedness actions, including ensuring appropriate laboratory capacity. All human infections with non-seasonal influenza viruses such as avian influenza A(H7N9) are reportable to WHO under the IHR (2005). 

     

    Similarly, the ECDC recently published an  Epidemiological Update on H7N9, which is current through the last reported case in Shenzhen on Wednesday of last week.

     

    After reviewing the data to date, the ECDC’s Risk Assessment at the end of this report illustrates the concern which many scientists and public health officials have regarding this virus.  They warn that public health authorities in the EU should be prepared for the importation of this virus, and close by stating::

     

    ECDC’s view is that if this virus persists in poultry, it will represent a significant long-term threat, either as a zoonosis or perhaps a pandemic virus. Both eventualities should be prepared for.

     

    So we watch these scattered cases carefully, looking for any signs that this virus is moving closer to becoming a serious public health threat.

    Hong Kong: Elderly H7N9 Case Has Died

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    # 8106

     

    Over the past month Hong Kong has detected two H7N9 cases – both presumably imported from Shenzhen in Guangdong Province – but diagnosed after arriving in the SAR.  The first case was a 36-year-old Indonesian domestic helper announced on December 2nd, while the second case – reported 4 days later – was an 80-year old man who lived in Shenzhen.


    Today, Hong Kong Health authorities announced that after more than 3 weeks in the hospital, the second patient has died. This from RTHK.

     

    80-year-old man diagnosed with H7N9 died

    Earlier diagnosis of H7N9 avian influenza in 80-year-old man, died in the afternoon.

     

    Patients Nagai Shenzhen, mainland was eating chicken, earlier this month because of physical discomfort, returned to Hong Kong to Tuen Mun Hospital for treatment, a quick test confirmed that he was infected with H7N9 avian influenza, and subsequently transferred to Princess Margaret Hospital for isolation and treatment.

     

    Secretary for Food and Health Ko Wing-man had visited before the patient and the patient had to pick up a taxi driver, the driver, after examination, confirmed that there were no symptoms.

    Wednesday, December 25, 2013

    Saudi MOH Confirms Five New MERS-CoV Cases (1 Fatal)

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    # 8105

     

    While there are news reports (see Crofsblog Saudi Arabia: A new MERS case in Riyadh? (updated and confirmed) of a new 20 year-old MERS patient at the "King Khaled Hospital,  KSA’s Ministry of Health has just posted a brief announcement of five new cases of MERS with ages ranging from 27 to 73 years of age.

     

    As is usual with Saudi announcements, details such as date of onset or diagnosis are not provided, so we don’t really know how recent these cases are.   Three of these cases are health care workers with reportedly mild or no symptoms.

     

     

    Health: 5 registered cases of HIV (Corona) in Riyadh new

    02/22/1435

    In the context of the work of epidemiological investigation and ongoing follow-up carried out by the Ministry of Health for the virus (Corona) that causes respiratory syndrome Middle East MERS-CoV Ministry announces the registration of five cases in Riyadh.

    The first citizen at the age of 57 years old, suffers from several chronic diseases and receiving treatment for intensive care, asking God cured him.

    The second citizen at the age of 73 years old, had been suffering from several chronic diseases, has passed away, may he rest in peace.

    And the third is a resident at the age of 43 years, working in the health sector and the communion of the confirmed case and has no symptoms.

    And the fourth to a resident at the age of 35 years, working in the health sector and Mkhalt of confirmed cases and has no symptoms.

    The fifth citizen at the age of 27 years, working in the health sector and Mkhalt of confirmed cases and has no symptoms. We ask God's healing them all.

    CDC HAN Advisory On Early pH1N1 Influenza Activity

     

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    # 8104

     

    After a couple of lackluster influenza seasons immediately following the 2009 pandemic, last year saw a particularly nasty H3N2 season, with some of the highest hospitalization and P&I mortality rates (particularly among the elderly) that we’d seen in a decade. 

     

    This year, it is the 2009 H1N1 virus (aka pH1N1) that is dominant, and it has already made a serious impact, particularly in the Southern tier of states (see Texas DSHS Statement On Recent Spike In Flu Activity). Unlike H3N2, which generally impacts the elderly hardest, H1N1 has a history of skewing towards younger patients.

     

    Late yesterday the CDC released a HAN ADVISORY to clinicians advising them of this early spike in flu activity, and the dominance of the pH1N1 strain. They continue to recommend vaccination, and the early administration of antivirals for anyone with confirmed or suspected influenza who is hospitalized; has severe, complicated, or progressive illness; or is at higher risk for influenza complications.

    You’ll find excerpts from this HAN advisory below.  Follow the link to read it in its entirety.

     

    Distributed via the CDC Health Alert Network
    December 24, 2013, 14:30 ET (2:30 PM ET)
    CDCHAN-00359

    Notice to Clinicians: Early Reports of pH1N1-Associated Illnesses for the 2013-14 Influenza Season

    Summary

    From November through December 2013, CDC has received a number of reports of severe respiratory illness among young and middle-aged adults, many of whom were infected with influenza A (H1N1) pdm09 (pH1N1) virus. Multiple pH1N1-associated hospitalizations, including many requiring intensive care unit (ICU) admission, and some fatalities have been reported. The pH1N1 virus that emerged in 2009 caused more illness in children and young adults, compared to older adults, although severe illness was seen in all age groups. While it is not possible to predict which influenza viruses will predominate during the entire 2013-14 influenza season, pH1N1 has been the predominant circulating virus so far. For the 2013-14 season, if pH1N1 virus continues to circulate widely, illness that disproportionately affects young and middle-aged adults may occur.

     

    Seasonal influenza contributes to substantial morbidity and mortality each year in the United States. In the 2012-13 influenza season, CDC estimates that there were approximately 380,000 influenza-associated hospitalizations [1]. Although influenza activity nationally is currently at low levels, some areas of the United States are already experiencing high activity, and influenza activity is expected to increase during the next few weeks.

     

    The spectrum of illness observed thus far in the 2013-14 season has ranged from mild to severe and is consistent with that of other influenza seasons. While CDC has not detected any significant changes in pH1N1 viruses that would suggest increased virulence or transmissibility, the agency is continuing to monitor for antigenic and genetic changes in circulating viruses, as well as watching morbidity and mortality surveillance systems that might indicate increased severity from pH1N1 virus infection. In addition, CDC is actively collaborating with state and local health departments in investigation and control efforts.

     

    CDC recommends annual influenza vaccination for everyone 6 months and older. Anyone who has not yet been vaccinated this season should get an influenza vaccine now. While annual vaccination is the best tool for prevention of influenza and its complications, treatment with antiviral drugs (oral oseltamivir and inhaled zanamivir) is an important second line of defense for those who become ill to reduce morbidity and mortality. Antiviral treatment is recommended as early as possible for any patient with confirmed or suspected influenza who is hospitalized; has severe, complicated, or progressive illness; or is at higher risk for influenza complications.

    (Continue . . . )

     

    A personal note: I know several people who have already been hit very hard by this year’s `flu’, and they have described it as being particularly `nasty’.  If you haven’t taken this year’s flu shot, it isn’t too late to do so.  It isn’t perfect protection, but can probably cut your odds of contracting the flu in half.


    And it is particularly important to maintain good flu hygiene right now.   The CDC recommends:

    • Wash your hands often with soap and water or an alcohol-based hand rub.
    • Avoid touching your eyes, nose, or mouth. Germs spread this way.
    • Try to avoid close contact with sick people.
    • Practice good health habits. Get plenty of sleep and exercise, manage your stress, drink plenty of fluids, and eat healthy food.
    • Cover your nose and mouth with a tissue when you cough or sneeze. Throw the tissue in the trash after you use it.
    • If you are sick with flu-like illness, stay home for at least 24 hours after your fever is gone without the use of fever-reducing medicine.

    Tuesday, December 24, 2013

    Referral: Dr. Ian Mackay On Recent MERS Studies In Camels

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    Coronavirus – Credit CDC PHIL

     

     

    # 8103

     

    While EID news is likely to be pretty slow between now and the New Year, Professor Mackay leaves us a little something under the tree this morning with his review of recent serological studies on MERS-CoV in Camels appearing in The Lancet and Eurosurveillance Journal over the past week. 

     

    Follow the link to read:

     

    Middle East respiratory syndrome coronavirus (MERS-CoV): camels, camels, camels!

    Two studies in Eurosurveillance, an editorial note, A Lancet Infectious diseases report and a comment point 2 hairy toes toward camels as a harbour and source in some capacity, for MERS-CoV, or MERS-CoV-very-like, infections ticking over around the Arabian peninsula. All in the space of a week!

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